| Cat. No. |
Product Name |
Information |
| PC-20679 |
FTX-6746
PPARγ inhibitor
|
FTX-6746 (FTX6746) is a potent, highly selective and orally active proliferator-activated receptor gamma (PPARG, PPARγ) inhibitor with cellular IC50 of 5 nM, >100-fold selectivity over PPARD and PPARA. |
| PC-20667 |
FX-909
PPARγ inverse agonist
|
FX-909 (FX909) is a potent, selective and covalent peroxisome proliferator-activated receptor gamma (PPARG, PPARγ) inverse agonist with cellular IC50 of 1 nM, >2000-fold selective over PPARα/PPARδ. |
| PC-20276 |
GSK3787
PPARδ antagonist
|
GSK3787 (GSK 3787) is a potent, selective and irreversible antagonist of PPARdelta (PPARδ) with binding pIC50 of 6.6, without measurable affinity for hPPARα or hPPARγ. |
| PC-49401 |
SR10221
PPARγ inverse agonist
|
SR10221 is a potent, selective PPARγ inverse agonist with IC50 of 13 nM in biochemical peptide recruitment assays, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines. |
| PC-49400 |
BAY-0069
PPARγ inverse agonist
|
BAY-0069 (BAY0069) is a potent, selective, covalent PPARγ inverse agonist with IC50 of 0.22 nM in cellular reporter assays. |
| PC-49399 |
BAY-4931
PPARγ inverse agonist
|
BAY-4931 (BAY4931) is a potent, selective, covalent PPARγ inverse agonist with IC50 of 0.17 nM in cellular reporter assays. |
| PC-49255 |
Leriglitazone
PPARγ agonist
|
MIN-102 (Leriglitazone) is a novel brain penetrant, selective and orally bioavailable PPARγ agonist with a potential best-in-class profile indicated for CNS diseases. |
| PC-49253 |
MBX-102 acid
PPARγ agonist
|
MBX-102 acid is the active form of JNJ39659100 (MBX-102), a selective partial PPAR-γ agonist with EC50 of 23.34 uM (hPPAR-γ), enhances insulin sensitivity in vitro in 3T3-L1 adipocytes, binds to the PPAR-γ LBD in a manner that is distinct from but overlapping with rosiglitazone. |
| PC-49252 |
JNJ 39659100
PPARγ agonist
|
JNJ39659100 (MBX-102) is a nonthiazolidinedione (TZD) selective partial PPAR-γ agonist with insulin-sensitizing and glucose-lowering properties comparable to TZDs without dose-dependent increases in body weight, the prodrug ester of MBX-102 acid. |
| PC-49036 |
GQ-16
PPARγ agonist
|
GQ-16 is a peroxisome proliferator-activated receptor γ (PPARγ) ligand and partial agonist with Ki value of 160 nM, specific for PPARγ with no detectable activity to activate other PPAR subtypes (PPARα or PPARβ/δ) or RXRα. |
| PC-38677 |
Ibrigampar
PPARγ modulator
|
Ibrigampar (AMG131, INT131, CHS131) is a selective, orally active PPARγ modulator (partial agonist) with binding IC50 of 17 nM, and PPARγ transactivation EC50 of 150 nM, enhances insulin sensitivity. |
| PC-38650 |
MMT-160
PPARγ inhibitor
|
MMT-160 is a novel selective peroxisome proliferator-activated receptor γ (PPARγ) antagonist with IC50 of 0.17 uM, covalently binds to the PPARγ ligand binding domain (LBD) via Cys285. |
