Cat. No. |
Product Name |
Information |
PC-20963 |
Pimavanserin
5-HT2A inverse agonist
|
Pimavanserin (ACP-103) is a potent, selective, orally active 5-HT2A receptor inverse agonist, competitively antagonizes the binding of [(3)H]ketanserin to heterologously expressed human 5-HT(2A) receptors with pKi of 9.3 in membranes and 9.70 in whole cells. |
PC-49806 |
5-HT2A agonist (R)-70
5-HT2A agonist
|
5-HT2A agonist (R)-70 is a potent selective 5-HT2A receptor partial agonist with EC50 of 110 nM in calcium flux assays, and Ki value of 880 nM. |
PC-49805 |
5-HT2A agonist (R)-69
5-HT2A agonist
|
5-HT2A agonist (R)-69 is a potent selective 5-HT2A receptor partial agonist with EC50 of 41 nM in calcium flux assays, and Ki value of 680 nM. |
PC-49161 |
AS2030680
5-HT5A antagonist
|
AS2030680 is a potent, selective and brain-penetrating 5-HT5A receptor antagonist with Ki of 0.58, 1.1 and 2.6 nM against human, rat, mouse 5-HT5A receptors, respectively. |
PC-49006 |
LY344864
5-HT1F agonist
|
LY344864 is a potent, selective agonist of 5-HT1F receptor with Ki value of 6 nM, with little to no affinity for other serotonergic and non-serotonergic neuronal binding sites. |
PC-47113 |
TZB-30878
5-HT1A agonist/5-HT3 antagonist
|
TZB-30878 is a potent, selective, orally bioavailable 5-HT1A agonist and 5-HT3 antagonist, selectively binds to human 5-HT1A and 5-HT) receptors with Kd values of 0.68 and 8.90 nM, respectively. |
PC-47112 |
CSTI-300
5-HT3 agonist
|
CSTI-300 (SMP-100) is a potent, selective 5-HT3 receptor partial agonist with high affinity for human and rat 5-HT3 receptor (Ki=2.0 nM). |
PC-38716 |
SB-699551
5-HT5A antagonist
|
SB699551 is a potent, selective 5-HT5A receptor antagonist with pKi of 8.3, >100-fold selectivity over 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors. |
PC-73308 |
NLX-101
5-HT1A agonist
|
NLX-101 (F15599) is a potent, highly selective post-synaptic 5-HT1A receptor agonist with Ki of 3.4 nM. |
PC-73305 |
PZ-1361
5-HT7 antagonist
|
PZ-1361 is a potent and selective 5-HT7 receptor antagonist with Ki of 33 nM, exhibit significant in vivo antidepressant and pro-cognitive properties in rodents. |
PC-72159 |
TPN672
5-HT agonist
|
TPN672 (TPN 672) is a novel antipsychotic compound with high affinity for serotonin and dopamine receptors 5-HT1AR, (Ki=0.23 nM), 5-HT2AR (Ki=2.58 nM) as well as moderate affinity for D3R (Ki=11.55 nM) and D2R (Ki=17.91 nM). |
PC-38060 |
SB 204741
5-HT2B antagonist
|
SB 204741 is a potent and selective 5-HT2B receptor antagonist (pA2=7.95). |