| Cat. No. |
Product Name |
Information |
| PC-43515 |
SB 242084
5-HT2C antagonist
|
SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist with pKi of 9.0, 100- and 158-fold selectivity over the closely related 5-HT2B and 5-HT2A subtypes. |
| PC-35022 |
SR57227 hydrochloride
5-HT3 agonist
|
SR-57227 is a high affinity, selective 5-HT3 receptor agonist, demonstrates anticonvulsant effects in vivo.. |
| PC-35021 |
SR-57227
5-HT3 agonist
|
SR-57227 is a high affinity, selective 5-HT3 receptor agonist, demonstrates anticonvulsant effects in vivo.. |
| PC-35018 |
Ro60-0175
5-HT2C agonist
|
Ro 60-0175 is a potent, selective 5-HT2C receptor agonist with pKi of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively. |
| PC-35004 |
PF-05212377
5-HT6 antagonist
|
PF-05212377 (SAM-760, PF 5212377) is a potent and selective 5-HT6 receptor antagonist with Ki of 0.32 nM (human 5HT6), shows potential therapy for the symptomatic treatment of mild to moderate Alzheimer's disease. |
| PC-63486 |
SB 258585 hydrochloride
5-HT6 antagonist
|
SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM, >160-fold selectivity over other 5-HT receptor subtypes. |
| PC-63485 |
SB-258585
5-HT6 antagonist
|
SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM, >160-fold selectivity over other 5-HT receptor subtypes. |
| PC-63483 |
SB-399885
5-HT6 antagonist
|
SB-399885 is a potent, selective, brain penetrant 5-HT6 receptor antagonist with pKi of 9.11 and 9.02 for human recombinant and native 5-HT6 receptors. |
| PC-63427 |
JNJ-5234801
|
JNJ-5234801 is an atypical anxiolytic targeting 5-HT2 receptor, has demonstrated oral activity in animal models of anxiety.. |
| PC-63289 |
CYD-1-79
5-HT2C PAM
|
CYD-1-79 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM), potentiates 5-HT-evoked intracellular calcium release in cells stably expressing the human 5-HT2CR but not the 5-HT2AR cells. |
| PC-63256 |
DSP-1053
SERT inhibitor, 5-HT1A agonist
|
DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively. |
| PC-43401 |
BRL54443
5-HT1E/1F agonist
|
BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively. |
