| Cat. No. |
Product Name |
Information |
| PC-45229 |
Ziprasidone hydrochloride monohydrate
D2/5-HT2A antagonist
|
Ziprasidone hydrochloride monohydrate (CP-88059) is a full antagonist of D2 and 5-HT2A receptors with Ki of 6.8 and 0.6 nM, respectively. |
| PC-43963 |
Ziprasidone
D2/5-HT2A antagonist
|
Ziprasidone (CP 88059) is a full antagonist of D2 and 5-HT2A receptors with Ki of 6.8 and 0.6 nM, respectively. |
| PC-26609 |
SB-656104A
5-HT7 antagonist
|
SB-656104A (SB-656104-A) is a potent, selective 5-HT7 receptor antagonist, potently inhibits [3H]-SB-269970 binding to the human cloned 5-HT7(a) (pKi=8.7) and 5-HT7(b) (pKi=8.5) receptor variants and the rat native receptor (pKi=8.8). |
| PC-26559 |
JZ‑1201
5-HT1A agonist
|
JZ‑1201 is a selective serotonin (5-HT)/norepinephrine (NE) reuptake inhibitor and partial agonist of the 5-HT1A receptor, exerts antidepressant-like effects. |
| PC-26558 |
Tropisetron
5-HT3R antagonist
|
Tropisetron (SDZ-ICS-930) is a potent, orally active 5-HT3R antagonist (Ki=5.3 nM), also is a potent and selective α7 nicotinic partial agonist (EC50=1.3 uM). |
| PC-26505 |
Cyproheptadine
5-HT2A antagonist
|
Cyproheptadine hydrochloride is a potent and orally active 5-HT2A receptor antagonist and histamine H1 receptor (HRH1) inverse agonist, promotes FOXO3 nuclear translocation and increases FOXO target genes while suppressing inflammation. |
| PC-26483 |
AG-670
NNMT inhibitor, 5-HT3 NAM
|
AG-670 (PU02) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT) with EC50 of 2.7 uM, also is a negative allosteric modulator (NAM) of 5-HT3 receptor with IC50 of 0.36 and 0.73 uM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively. |
| PC-26338 |
Lumocaserin hydrochloride
5-HT2C agonist
|
Lumocaserin hydrochloride is a potent, selective serotonin 2C receptor (5-HT2C receptor) agonist with EC50 of 11 nM (Emax=88%), with limited activity against 5-HT2B and 5-HT2A receptors. |
| PC-26337 |
Lumocaserin
5-HT2C agonist
|
Lumocaserin is a potent, selective serotonin 2C receptor (5-HT2C receptor) agonist with EC50 of 11 nM (Emax=88%), with limited activity against 5-HT2B and 5-HT2A receptors. |
| PC-26210 |
GSK958108
5HT1A antagonist
|
GSK958108 (GSK-958108) is a potent, selective and orally bioavailable 5HT1A receptor antagonist. |
| PC-25920 |
SB-216641A
5-HT1B antagonist
|
SB-216641A (SB-216641 hydrochloride) is a selective partial agonist/antagonist of 5-HT1B receptor, shows high affinity and selectivity for h5-HT1B receptors over h5-HT1D receptors, inhibits the function of SKF-99101H. |
| PC-25761 |
25C-NBF
5-HT2A agonist
|
25C-NBF is a potent, selective 5-HT2A agonist with binding Ki of 0.8 nM and calcium mobilization EC50 of 2.3 nM, displays 2625-, 180-, 59-fold selective over 5-HT1A, 5-HT2B and 5-HT2C receptors respectively, exhibits antidepressant effects. |
