| Cat. No. |
Product Name |
Information |
| PC-25012 |
WAY-208466
5-HT6 agonist
|
WAY-208466 (WAY 208466 dihydrochloride) is a potent and selective 5-HT6 receptor agonist with EC50 of 7.3 nM for human 5-HT6 receptor, shows antidepressant-like and anxiolytic-like effects. |
| PC-24958 |
AVN-101 hydrochloride
5-HT7 antagonist
|
Maritupirdine hydrochloride (AVN-101) is a higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki = 1.2-2.0 nM). |
| PC-24893 |
MDL11939
5-HT2A antagonist
|
MDL11939 (Glemanserin) is a potent and selective antagonist for serotonin receptor 5-HT2A with Ki values of 2.89, 0.54 and 2.5 nM for rat, rabbit and human 5-HT2A receptors, respectively. |
| PC-24892 |
LY272015
5-HT2B antagonist
|
LY272015 hydrochloride is a potent, selective and orally bioactive 5-HT2B receptor (5-HT2BR) antagonist with IC50 of 0.26 nM. |
| PC-24891 |
MARY1
5-HT2B antagonist
|
MARY1 is potent, and selective 5-hydroxytryptamine 2B receptor (5-HT2BR) antagonist with Ki of 764 nM, induces mitochondrial biogenesis (MB) enhances mitochondrial function in the kidney. |
| PC-24876 |
Palonosetron hydrochloride
5-HT3 antagonist
|
Palonosetron (RS 25259-197) is a potent, selective 5-HT3 receptor antagonist with pKi value of 10.4, >10,000-fold selective over 5-HT1A/1D/2A/2C receptors. |
| PC-24462 |
NLX-266
5-HT1A agonist
|
NLX-266 is a potent, selective, orally available and metabolically stable ERK1/2-biased 5-HT1A receptor agonist with binding pKi of 10.35, >1000-fold selective over adrenergic α1 and dopaminergic D2 receptors. |
| PC-24453 |
Brexpiprazole
CAS 913611-97-9
|
Brexpiprazole (OPC-34712) is an atypical orally active antipsychotic agent and partial agonist of human 5-HT1A and dopamine D2L receptor with Ki of 0.12 nM and 0.3 nM, respectively. |
| PC-24324 |
MW073
5-HT2bR inhibitor
|
MW073 is a highly selective and orally bioavailable inhibitor of 5-HT2b receptor (5-HT2bR) with binding IC50 of 70 nM. |
| PC-24283 |
AM1476
5-HT2B inhibitor
|
AM1476 is a highly selective 5-HT2B receptor (5-HT2BR) inhibitor with IC50 of 5.8 nM, showed only low activity at the5-HT2AR (IC50 >10 000 nM) and 5-HT2CR. |
| PC-24221 |
PUC-55
5-HT6R antagonist
|
PUC-10 is a selective 5-HT6 receptor antagonist high binding affinity (Ki=37.5 nM), induces autophagy in the neuroblastoma SH-SY5Y cell line by inhibiting the mTOR pathway. |
| PC-24220 |
PUC-10
5-HT6R antagonist
|
PUC-10 is a selective 5-HT6 receptor antagonist high binding affinity (Ki=14.6 nM) and IC50 of 32 nM in calcium mobilisation functional assay, induces mTOR-dependent autophagy. |
