| Cat. No. |
Product Name |
Information |
| PC-61503 |
AVN-322 free base
5-HT6 antagonist
|
AVN-322 free base is a highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia. |
| PC-61502 |
AVN-322
5-HT6 antagonist
|
AVN-322 is a highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia. |
| PC-61500 |
SUVN-502
5-HT6 antagonist
|
SUVN-502 (SUVN502, Masupirdine) is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM. |
| PC-61221 |
MKC-733
5-HT3 agonist
|
MKC-733 (Pumosetrag, DDP 733) is a potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors. |
| PC-61178 |
SB-357134
5-HT6 antagonist
|
SB-357134 is a potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes. |
| PC-61117 |
WAY 163909
5-HT2C agonist
|
WAY 163909 is a highly potent, subtype-selective agonist of 5-HT2C receptor with Ki of 10.5 nM, >20-fold selectivity over 5-HT2A and 5-HT2B receptor subtypes (IC50=212 and 485 nM, respectively). |
| PC-61106 |
MIN-117
5-HT1A/2A antagonist
|
MIN-117 (WF-516) is a small molecule 5-HT1A and 5-HT2A receptor antagonist and inhibitor of serotonin and dopamine reuptake, also possess affinity for the α1A- and α1B-adrenergic receptors. |
| PC-61081 |
PF-03246799
5-HT2C agonist
|
PF-03246799 (PF-3246799) is a potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A. |
| PC-61080 |
PF-04781340
5-HT2C agonist
|
PF-04781340 is a potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability. |
| PC-60817 |
MK-212
5-HT2C agonist
|
MK-212 is a potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A. |
| PC-60816 |
BW-723C86
5-HT2B agonist
|
BW-723C86 is a potent, selective 5-HT2B receptor agonist with pKi of 7.1, >10-fold selectivity over 5-HT2A, 5-HT2C, and other 5-HT subtypes. |
| PC-60815 |
RS-102221
5-HT2C antagonist
|
RS-102221 is a highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively. |
