| Cat. No. |
Product Name |
Information |
| PC-61080 |
PF-04781340
5-HT2C agonist
|
PF-04781340 is a potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability. |
| PC-60817 |
MK-212
5-HT2C agonist
|
MK-212 is a potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A. |
| PC-60816 |
BW-723C86
5-HT2B agonist
|
BW-723C86 is a potent, selective 5-HT2B receptor agonist with pKi of 7.1, >10-fold selectivity over 5-HT2A, 5-HT2C, and other 5-HT subtypes. |
| PC-60815 |
RS-102221
5-HT2C antagonist
|
RS-102221 is a highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively. |
| PC-60814 |
MDL100907
5-HT2A inhibitor
|
MDL100907 (Volinanserin) is a potent, selective 5-HT2A receptor antagonist with Ki of 0.36 nM, > 80-fold selectivity for 5-HT2A over other serotonergic receptors. |
| PC-60813 |
25CN-NBOH
5-HT2A agonist
|
25CN-NBOH is a potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin). |
| PC-60738 |
AZD3676
5-HT1A/1B antagonist
|
AZD3676 is a potent, combined serotonin 5-HT1A and 5-HT1B receptor antagonist with Ki of 0.13 and 2.4 nM in brain homogenates, respectively. |
| PC-60522 |
NBUMP
5-HT1A agonist
|
NBUMP is a potent, highly selective 5-HT1A receptor partial agonist with Ki of 0.1 nM, displays 460- and 260-fold selectivity for 5-HT1A over the α1-adrenergic and D2 receptors, respectively. |
| PC-60521 |
Minesapride
|
Minesapride (DSP-6952) is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c. |
| PC-70076 |
Lumateperone
|
Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM). |
| PC-70074 |
Frovatriptan succinate hydrate
5-HT1B/1D agonist
|
Frovatriptan (SB209509, VML251) succinate hydrate is a potent, long lasting 5-HT(1B/1D) receptor agonist with pK50 of 8.2(5-HT1B). |
| PC-45732 |
NAN-190 hydrobromide
5-HT1A antagonist
|
NAN-190 hydrobromide is a potent, selective 5-HT1A receptor antagonist with Ki of 0.6 nM. |
