| Cat. No. |
Product Name |
Information |
| PC-61178 |
SB-357134
5-HT6 antagonist
|
SB-357134 is a potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes. |
| PC-61117 |
WAY 163909
5-HT2C agonist
|
WAY 163909 is a highly potent, subtype-selective agonist of 5-HT2C receptor with Ki of 10.5 nM, >20-fold selectivity over 5-HT2A and 5-HT2B receptor subtypes (IC50=212 and 485 nM, respectively). |
| PC-61106 |
MIN-117
5-HT1A/2A antagonist
|
MIN-117 (WF-516) is a small molecule 5-HT1A and 5-HT2A receptor antagonist and inhibitor of serotonin and dopamine reuptake, also possess affinity for the α1A- and α1B-adrenergic receptors. |
| PC-61081 |
PF-03246799
5-HT2C agonist
|
PF-03246799 (PF-3246799) is a potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A. |
| PC-61080 |
PF-04781340
5-HT2C agonist
|
PF-04781340 is a potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability. |
| PC-60817 |
MK-212
5-HT2C agonist
|
MK-212 is a potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A. |
| PC-60816 |
BW-723C86
5-HT2B agonist
|
BW-723C86 is a potent, selective 5-HT2B receptor agonist with pKi of 7.1, >10-fold selectivity over 5-HT2A, 5-HT2C, and other 5-HT subtypes. |
| PC-60815 |
RS-102221
5-HT2C antagonist
|
RS-102221 is a highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively. |
| PC-60814 |
MDL100907
5-HT2A inhibitor
|
MDL100907 (Volinanserin) is a potent, selective 5-HT2A receptor antagonist with Ki of 0.36 nM, > 80-fold selectivity for 5-HT2A over other serotonergic receptors. |
| PC-60813 |
25CN-NBOH
5-HT2A agonist
|
25CN-NBOH is a potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin). |
| PC-60738 |
AZD3676
5-HT1A/1B antagonist
|
AZD3676 is a potent, combined serotonin 5-HT1A and 5-HT1B receptor antagonist with Ki of 0.13 and 2.4 nM in brain homogenates, respectively. |
| PC-60522 |
NBUMP
5-HT1A agonist
|
NBUMP is a potent, highly selective 5-HT1A receptor partial agonist with Ki of 0.1 nM, displays 460- and 260-fold selectivity for 5-HT1A over the α1-adrenergic and D2 receptors, respectively. |
