| Cat. No. |
Product Name |
Information |
| PC-23280 |
Prucalopride
5-HT4 agonist
|
Prucalopride (R-108512) is a potent, selective 5-HT4 receptor agonist with pKi of 8.6 and 8.1 for 5-HT4a and 5-HT4b, >290-fold higher affinity for 5-HT4 receptors than for other receptors. |
| PC-23244 |
GSK215083
5-HT6 antagonist
|
GSK215083 is a potent, selective 5-HT6 receptor antagonist. |
| PC-22773 |
8-OH-DPAT
5-HT1A agonist
|
8-OH-DPAT (8-Hydroxy-DPAT) is a potent and selective 5-HT1A receptor agonist with pIC50 of 8.19, has moderate affinity for 5-HT7 receptors (pKi is 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells). |
| PC-22599 |
MT-1207 hydrochloride
α1/5-HT2A antagonist
|
MT-1027 hydrochloride is a highly potent α1 adrenoceptor and 5-HT2A receptor antagonist with IC50 of <0.1 nM and 0.27 nM respectively. |
| PC-22598 |
MT-1207
α1/5-HT2A antagonist
|
MT-1027 is a highly potent α1 adrenoceptor and 5-HT2A receptor antagonist with IC50 of <0.1 nM and 0.27 nM respectively. |
| PC-22530 |
RE104
5-HT2A agonist
|
RE104 is the prodrug of 4-OH-DiPT, a synthetic 5-hydroxytryptamine 2A receptor (5-HT2A receptor) agonist with Ki of 0.12 uM. |
| PC-22529 |
4-OH-DiPT
5-HT2A agonist
|
4-OH-DiPT is a synthetic 5-hydroxytryptamine 2A receptor (5-HT2A receptor) agonist with Ki of 0.12 uM, shows strongest agonist activity at all three 5-HT2A/2B/2C receptors with near full agonist activity at 5-HT2A. |
| PC-22510 |
DSP-6745
SERT/5-HT inhibitor
|
DSP-6745 is a potent inhibitor of 5-HT transporter (human SERT, Ki=0.653 nM), and 5-HT2A, 5-HT2C, and 5-HT7 receptors with Ki of 0.331, 1.34, and 31.7 nM, respectively. |
| PC-22491 |
XOB
5-HT2A/VGSC antagonist
|
XOB is a selective antagonist of 5-HT2A receptor and voltage-gated sodium channels, simultaneously antagonizes 5-HT2A receptors and blocks sodium voltage-gated sodium channels (VGSCs). |
| PC-22332 |
ITI-333
5-HT2A agonist
|
ITI-333 is a potent, brain-penetrant, orally bioavailable 5-HT2A receptor antagonist (Ki =8 nM) and a biased, partial agonist at μ-opioid (MOP) receptors (Ki =11 nM, lacking β-arrestin agonism). |
| PC-22310 |
S32212
5-HT2C antagonist
|
S32212 is a combined serotonin (5-HT)(2C) receptor inverse agonist and α(2)-adrenoceptor antagonist with pKi of8.2 (h5-HT2C), pKi of 7.2-8.2 for α(2A), α(2B) and α(2C). |
| PC-22278 |
SB 269970 hydrochloride
5-HT7 antagonist
|
SB269970 (SB-269970) hydrochloride is a potent, selective 5-HT7 receptor antagonist with pKi of 8.9, >100-fold selective over other 5-HT receptors. |
