Cat. No. |
Product Name |
Information |
PC-73307 |
Felcisetrag
5-HT4 agonist
|
Felcisetrag (TAK-954, TD-8954) is a highly selective and potent 5-HT4 receptor agonist with pKi of 9.4 (human 5-HT4). |
PC-73306 |
ASP2205
5-HT2C agonist
|
ASP2205 (ASP2205 fumarate) is a potent, selective 5-HT2C receptor agonist with EC50 of 0.85/2.5 nM for human/rat 5-HT2C in the intracellular Ca2+ mobilization assays, respectively. |
PC-73305 |
PZ-1361
5-HT7 antagonist
|
PZ-1361 is a potent and selective 5-HT7 receptor antagonist with Ki of 33 nM, exhibit significant in vivo antidepressant and pro-cognitive properties in rodents. |
PC-73304 |
AGH-192
5-HT7 agonist
|
AGH-192 is a potent, selective, orally bioavailable 5-HT7 receptor agonist with Ki of 4 nM. |
PC-73303 |
AGH-107
5-HT7 agonist
|
AGH-107 is a potent, selective 5-HT7 receptor agonist with Ki of 6 nM and EC50 of 19 nM, 176-fold selectivity over 5-HT1AR. |
PC-73302 |
AVN-492
5-HT6 antagonist
|
AVN-492 is a highly potent and selective 5-HT6 receptor antagonist with Ki of 91 pM, >1000-fold selectivity over 5-HT2BR (Ki=170 nM). |
PC-73301 |
ST1936 oxalate
5-HT6 agonist
|
ST1936 is a potent, selective 5-HT6 receptor agonist with Ki of 13 nM, >10-fold selectivity over 5-HT7 and 5-HT2B receptors. |
PC-73300 |
LP-211
5-HT7 agonist
|
LP-211 is a potent, selective, and BBB-penetrant 5-HT7 receptor agonist with Ki of 0.58 nM, high selectivity over 5-HT1A receptor (Ki, 188 nM) and D2 receptor (Ki, 142 nM). |
PC-73299 |
Usmarapride
5-HT4 agonist
|
Usmarapride (SUVN-D4010) is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist with EC50of 44 nM. |
PC-43516 |
SB 242084 hydrochloride
|
SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist with pKi of 9.0, 100- and 158-fold selectivity over the closely related 5-HT2B and 5-HT2A subtypes. |
PC-35019 |
Ro 60-0175 fumarate
|
Ro 60-0175 is a potent, selective 5-HT2C receptor agonist with pKi of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively. |
PC-63484 |
SB-399885 hydrochloride
|
SB-399885 is a potent, selective, brain penetrant 5-HT6 receptor antagonist with pKi of 9.11 and 9.02 for human recombinant and native 5-HT6 receptors. |