| Cat. No. |
Product Name |
Information |
| PC-72174 |
ONC206
DRD2 inhibitor
|
ONC206 (ONC 206) is a chemical analogue of ONC201, a selective antagonist of dopamine D2-like receptor (DRD2, Ki=320 nM) with broad-spectrum anti-tumor activity. |
| PC-38113 |
LY3154885
Dopamine D1 modulator
|
LY 3154885 is a potent dopamine D1 receptor positive allosteric modulator (PAM) with EC50 of 11.7 nM. |
| PC-35905 |
VK4-116
D3R antagonist
|
VK4-116 is a novel potent, highly selective dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, displays >1,000-fold selectivity over D2R. |
| PC-35537 |
PCC0104005
Dopamine/5-HT modulator
|
PCC0104005 (Brilaroxazine hydrochloride) is a modulator of serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2, D3, D4, serotonin 5-HT1A, and 5-HT2A receptors and antagonism at 5-HT2B, 5-HT6, and 5-HT7 receptors. |
| PC-35534 |
MLS1082
|
MLS1082 is a novel positive allosteric modulator of the D1 dopamine receptor, potentiatse dopamine-stimulated G-protein- and β-arrestin-mediated signaling and increase the affinity of dopamine for the D1 receptor with low micromolar potencies.. |
| PC-35533 |
MLS6585
D1 dopamine PAM
|
MLS6585 is a novel positive allosteric modulator of the D1 dopamine receptor, potentiatse dopamine-stimulated G-protein- and β-arrestin-mediated signaling and increase the affinity of dopamine for the D1 receptor with low micromolar potencies. |
| PC-35490 |
D-520
D2/D3 agonist
|
D-520 is a potent, multifunctional D2/D3 agonist with Ki of 41.8 /0.35 nM, modulates aggregation of alpha-synuclein (αSN) and reduces toxicity of preformed aggregates of αSN. |
| PC-35468 |
Tavapadon
Dopamine D1/D5 agonist
|
Tavapadon (CVL-75, PF-06649751) is a potent, selective orally available dopamine D1/D5 receptor partial agonist with Ki of 9 nM/13 nM, respectively. |
| PC-63551 |
Zicronapine
|
Zicronapine is an antipsychotic agent that shows potent antagonistic effects at dopamine D1, D2 and serotonin 5HT2A receptors, exhibits monoaminergic activity and has a multi-receptorial profile.. |
| PC-63349 |
BRD5814
D2R inhibitor
|
BRD5814 is a potent, selective, highly brain penetrant β-arrestin biased dopamine D2 receptor (D2R) antagonist with Ki of 0.27 uM. |
| PC-43160 |
Bromocriptine mesylate
D2R agonist
|
Bromocriptine (CB-154) is a dopamine D2 receptor agonist (Ki=3 nM) and and various serotonin receptors, also inhibits the release of glutamate by reversing the glutamate GLT1 transporter. |
| PC-42975 |
SB269652
D2R/D3R modulator
|
SB269652 is a potent, selective, negative allosteric modulator of dopamine D2 and D3 receptors, abolishes specific binding of [3H]nemanopride and [3H]spiperone to CHO-transfected D3 receptors with IC50 of1.86 and 0.18 nM. |
