| Cat. No. |
Product Name |
Information |
| PC-72174 |
ONC206
DRD2 inhibitor
|
ONC206 (ONC 206) is a chemical analogue of ONC201, a selective antagonist of dopamine D2-like receptor (DRD2, Ki=320 nM) with broad-spectrum anti-tumor activity. |
| PC-72158 |
ML417
D3R agonist
|
ML417 (ML 417) is a novel potent and uniquely selective D3 dopamine receptor (D3R) full agonist with EC50 of 38 nM in β-arrestin recruitment assays. |
| PC-72157 |
CJ-1639
D3R agonist
|
CJ-1639 (CJ1639) is a potent, highly selective dopamine D3 receptor (D3R) full agonist with Ki of 0.5 nM, >5,000-fold selectivity over D1 and D2 receptors in binding assays. |
| PC-38113 |
LY3154885
Dopamine D1 modulator
|
LY 3154885 is a potent dopamine D1 receptor positive allosteric modulator (PAM) with EC50 of 11.7 nM. |
| PC-35989 |
SK609
D3R agonist
|
SK609 (SK-609, ES609) is a potent, selective agonist of dopamine D3 receptor with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation. |
| PC-35905 |
VK4-116
D3R antagonist
|
VK4-116 (VK04-116) is a novel potent, highly selective dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, displays >1,000-fold selectivity over D2R. |
| PC-35799 |
PF-06256142
D1 dopamine agonist
|
PF-06256142 (PF06256142) is a potent and selective orthosteric agonist of the D1 receptor with EC50 (cAMP) of 33 nM, shows exquisitely selectivity over D2. |
| PC-35537 |
PCC0104005
Dopamine/5-HT modulator
|
PCC0104005 (Brilaroxazine hydrochloride) is a modulator of serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2, D3, D4, serotonin 5-HT1A, and 5-HT2A receptors and antagonism at 5-HT2B, 5-HT6, and 5-HT7 receptors. |
| PC-35534 |
MLS1082
D1 dopamine PAM
|
MLS1082 is a novel positive allosteric modulator of the D1 dopamine receptor, potentiatse dopamine-stimulated G-protein- and β-arrestin-mediated signaling (EC50=123 nM). |
| PC-35533 |
MLS6585
D1 dopamine PAM
|
MLS6585 is a novel positive allosteric modulator of the D1 dopamine receptor, potentiatse dopamine-stimulated G-protein- and β-arrestin-mediated signaling and increase the affinity of dopamine for the D1 receptor with low micromolar potencies. |
| PC-35490 |
D-520
D2/D3 agonist
|
D-520 is a potent, multifunctional D2/D3 agonist with Ki of 41.8 /0.35 nM, modulates aggregation of alpha-synuclein (αSN) and reduces toxicity of preformed aggregates of αSN. |
| PC-35468 |
Tavapadon
Dopamine D1/D5 agonist
|
Tavapadon (CVL-75, PF-06649751) is a potent, selective orally available dopamine D1/D5 receptor partial agonist with Ki of 9 nM/13 nM, respectively. |
