| Cat. No. |
Product Name |
Information |
| PC-49552 |
DPI-287
DOP agonist
|
DPI-287 is a small-molecule agonist of the δ-opioid receptor (DOP, DOR) with Ki vaule of 0.39 nM, shows 10-fold selectivity for DOP over MOP (Ki=3.17 nM). |
| PC-49035 |
MP135
μ-δ opioid agonist
|
MP135 is a potent, μ-δ opioid receptor heteromer-selective agonist with EC50 of 0.8 nM in GTPγS assays, shows functional selectivity for μ-δ heteromers over homomeric μOR and δOR and low β-arrestin2 recruitment activity. |
| PC-49002 |
PN6047
DOR agonist
|
PN6047 is an orally bioavailable, G protein-biased and selective δ opioid agonist with pKi of 7.25, fully engages G protein signaling but is a partial agonist in both the arrestin recruitment and internalization assays. |
| PC-47026 |
AT-039
NOP agonist
|
AT-039 is a potent, selective agonist of nociceptin opioid peptide (NOP) receptor, AT-039 is useful for treatment of hypertension and/or volume overload/hyponatraemic states. |
| PC-38589 |
BPR1M97
MOP/NOP agonist
|
BPR1M97 is a dual-acting mu-opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist with Ki values of 1.8 and 4.2 nM, respectively. |
| PC-38532 |
BMS 986188
δ-opioid PAM
|
BMS 986188 is a potent, selective positive allosteric modulator of δ-opioid receptor with EC50 of 0.05 uM in β-arrestin recruitment assays, no significant acitivity against μ-opioid receptors. |
| PC-73447 |
Tegileridine
MOR agonist
|
Tegileridine is a selective mu opioid receptor (MOR) agonist with analgesic activity. |
| PC-73442 |
Riminkefon
KOR agonist
|
Riminkefon is a potent kappa opioid receptor (KOR) agonist with analgesic activity. |
| PC-72734 |
R995045
Delta Opioid agonist
|
R995045 is a novel δ-opioid receptor (δOR) agonist with pKi of 5.94, cAMP pIC50 of 6.01, >10-fold selectivity over µOR and κOR. |
| PC-36056 |
BTRX-335140
KOR antagonist
|
BTRX-335140 (Navacaprant, CYM-53093) is a potent, selective, orally active κ opioid receptor (KOR) antagonist with IC50 of 0.8 nM. |
| PC-35539 |
NFEPP
MOR agonist
|
NFEPP is a novel potent, selective pH-dependent μ-opioid receptor (MOR) agonist with a low pKa, shows significantly lower affinity compared with fentanyl at pH 7.4. |
| PC-35296 |
BU09059
KOR antagonist
|
BU09059 is a potent, selective, short-acting kappa-opioid receptor antagonist with Ki of 1.72 nM, displays 15- and 616-fold selectivity over μ- and δ-receptors respectively. |
