| Cat. No. |
Product Name |
Information |
| PC-49035 |
MP135
μ-δ opioid agonist
|
MP135 is a potent, μ-δ opioid receptor heteromer-selective agonist with EC50 of 0.8 nM in GTPγS assays, shows functional selectivity for μ-δ heteromers over homomeric μOR and δOR and low β-arrestin2 recruitment activity. |
| PC-49002 |
PN6047
δ opioid agonist
|
PN6047 is an orally bioavailable, G protein-biased and selective δ opioid agonist with pKi of 7.25, fully engages G protein signaling but is a partial agonist in both the arrestin recruitment and internalization assays. |
| PC-72734 |
R995045
Delta Opioid agonist
|
R995045 is a novel δ-opioid receptor (δOR) agonist with pKi of 5.94, cAMP pIC50 of 6.01, >10-fold selectivity over µOR and κOR. |
| PC-36056 |
BTRX-335140
|
BTRX-335140 (CYM-53093, BTRX335140, CYM53093) is a potent, selective, orally active κ opioid receptor (KOR) antagonist with IC50 of 0.8 nM. |
| PC-35296 |
BU09059
KOR antagonist
|
BU09059 is a potent, selective, short-acting kappa-opioid receptor antagonist with Ki of 1.72 nM, displays 15- and 616-fold selectivity over μ- and δ-receptors respectively. |
| PC-35217 |
Cebranopadol
ORL1 agonist
|
Cebranopadol (GRT-6005, GRT6005) is a potent analgesic nociceptin/orphanin FQ peptide (NOP receptor, ORL1) and opioid receptor agonist with Ki/EC50 of 0.9/13 nM (human NOP receptor), 0.7/1.2 nM (mu-opioid receptor). |
| PC-43402 |
BAN ORL 24
ORL1 inhibitor
|
BAN ORL 24 is a potent, selective, non-peptide nociceptin/orphanin FQ receptor (NOP receptor, ORL1) antagonist with IC50 of 0.27 nM, displays no significant activity for κ-, μ- and δ-receptors. |
| PC-43352 |
ADL5859
DOR agonist
|
ADL5859 is a potent, selective, orally bioavailable full agonist of δ opioid receptor (DOR) with Ki of 0.84 nM and EC50 of 20 nM. |
| PC-63082 |
BMS-986187
|
BMS-986187 is a novel potent, positive allosteric modulator of δ-opioid receptor with EC50 of 30 nM, 100-fold selectivity over μ-opioid receptor. |
| PC-62626 |
JTC-801
ORL1 agonist
|
JTC-801 is a highly potent, selective, orally active NOP receptor (ORL1) antagonist with Ki of 8.2 nM, shows 12.5-, 129- and 1055-fold selectivity over human μ-, κ- and δ-opioid receptors respectively. |
| PC-62146 |
ML335
|
ML335 is an agonist probe for opioid receptor mu 1 (OPRM1)-opioid receptor delta 1 (OPRD1) heterodimerization with EC50 of 403 nM. |
| PC-62110 |
LY 2456302
KOR antagonist
|
LY 2456302 (CERC-501, JSPA 0658, Aticaprant) is a potent, selective, short-acting antagonist of κ-opioid receptor (KOR) with Ki of 0.81 nM. |
