| Cat. No. |
Product Name |
Information |
| PC-23410 |
PDE1 inhibitor 3f
PDE1 inhibitor
|
PDE1 inhibitor 3f is a potent, selective PDE1 inhibitor with IC50 of 11 nM, >24-fold selectivity over other PDEs, shows antifibrotic effects in vivo and in vitro. |
| PC-23407 |
Vardenafil
PDE5 inhibitor
|
Vardenafil is a potent, selective and orally active inhibitor of phosphodiesterase-5 (PDE5), inhibits the hydrolysis of cGMP by PDE5 with IC50 of 0.7 nM. |
| PC-23406 |
RF26
PDE5 inhibitor
|
RF26 (Compound d12) is a highly potent and selective PDE5 inhibitor with IC50 of 1 nM, three times more potent than sildenafil and more selective with a selectivity index of >10,000-fold against all other PDE isozymes. |
| PC-23243 |
Senazodan hydrochloride
PDE3 inhibitor
|
Senazodan (MCI-154) hydrochloride is a small molecule Ca2+-sensitiser and PDE3 inhibitor, exerts positive inotropic and chronotropic effects by binding directly to troponin C. |
| PC-23242 |
Pimobendan
PDE3 inhibitor
|
Pimobendan (UD-CG115) is an oral Ca2+-sensitiser and PDE3 inhibitor (IC50=320 nM). |
| PC-22654 |
PDE4B/PDE5A inhibitor MDL3
PDE4B/PDE5A inhibitor
|
MDL3 is a potent, dual inhibitor of PDE4B and PDE5A, ameliorates pathophysiological signs and symptoms of liver injury and inflammation. |
| PC-22040 |
YM976
PDE4 inhibitor
|
YM976 is a potent, selective phosphodiesterase type 4 (PDE4) inhibitor with IC50 of 2.2 nM against PDE4 purified from human peripheral leukocytes. |
| PC-22039 |
BAY 60-7550
PDE2 inhibitor
|
BAY 60-7550 (Bay60-7550) is a potent and selective PDE2 inhibitor with Ki of 3.8 nM, IC50 of 4.7 nM (human PDE2A), and 2.0 nM (bovine purified PDE2). |
| PC-22038 |
CT-2450
PDE4 inhibitor
|
CT-2450 is a potent, selective phosphodiesterase (PDE IV, PDE4) inhibitor. |
| PC-21899 |
Anagrelide hydrochloride
PDE3 inhibitor
|
Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) with IC50 of 36 nM, inhibits platelet aggregation and bone marrow megakaryocytopoiesis. |
| PC-21518 |
D159687
PDE4D inhibitor
|
D159687 is a selective, negative allosteric modulator (inhibitor) of PDE4D with IC50 of 1.9 nM, >1,000 time more selective against PDE4 compared with other PDEs. |
| PC-20981 |
PDE12 inhibitor Compound 1
PDE12 inhibitor
|
PDE12 inhibitor Compound 1 is a potent, selective inhibitor of phosphodiesterase 12 (PDE12) with pIC50 of 9.1 and Ki of 17.5 nM, >1000-fold selectivity over EEP nuclease family member CNOT6. |
