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Cat. No. Product Name Information
PC-43051

TAK-063

PDE10A inhibitor

TAK-063 (Balipodect) is a highly potent, selective, orally active PDE10A inhibitor with IC50 of 0.3 nM, displays >15,000-fold selectivity over other PDE subtypes.
PC-42971

IBMX

PDEs inhibitor

IBMX (Isobutylmethylxanthine, Methylisobutylxanthine, NSC165960) is a broad-spectrum inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) with IC50 of 5-50 uM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11.
PC-42891

Apremilast

PDE4 inhibitor

Apremilast (CC-10004) is a potent, orally active PDE4 inhibitor with IC50 of 74 nM, inhibits TNF-α production in LPS-stimulated hPBMCs with IC50 of 77 nM.
PC-63121

PDE4D-IN-26b

PDE4D inhibitor

PDE4D-IN-26b is a potent, highly selective PDE4D inhibitor with IC50 of 0.6 nM, displays 75-fold lower activity against the PDE4A, B, and C subtypes, also exhibits 18,000-fold decreased potency against other PDE family members.
PC-63097

CDP-840 hydrochloride

PDE4 inhibitor

CDP-840 (CDP840.
PC-63096

CDP-840

PDE4 inhibitor

CDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast.
PC-63095

ONO-6126

PDE4 inhibitor

ONO-6126 is a potent and selective PDE4 inhibitor for the treatment of bronchial asthma and allergic conjunctivitis..
PC-63094

Oglemilast

PDE4 inhibitor

Oglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively..
PC-63093

Tetomilast

PDE4 inhibitor

Tetomilast (OPC-6535) is a superoxide anion production inhibitor that inhibits PDE4 and proinflammatory functions of leukocytes including superoxide production and cytokine release.
PC-63092

Filaminast

PDE4 inhibitor

Filaminast (WAY-PDA-641, PDA-641, WAY-123641) is a potent and selective PDE4 inhibitor with IC50 of 420 nM, displays 36-fold selectivity over PDE3.
PC-63091

Lirimilast

PDE4 inhibitor

Lirimilast (BAY19-8004, BAY 198004) is a potent and selective PDE4 inhibitor with IC50 of 49 nM, shows potential for the treatment of COPD.
PC-63090

Tofimilast

PDE4 inhibitor

Tofimilast (CP-325366) is a potent, selective PDE4 inhibitor with IC50 of 23, 13 and 13 nM for PDE4A, PDE4B, and PDE4D, respectively.

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