| Cat. No. |
Product Name |
Information |
| PC-24965 |
LEO 29102
PDE4 inhibitor
|
LEO 29102 is a potent, selective, and soft-drug PDE4 inhibitor with IC50 of 5 nM (PDE4D), inhibits TNFα release from hPBMCs stimulated with LPS with IC50 of 16 nM. |
| PC-24964 |
LEO 39652
PDE4 inhibitor
|
LEO 39652 is a potent, selective PDE4 inhibitor with IC50 of 1.2/1.2/3.0/3.8 nM for PDE4A/B/C/D respectively, selective over other PDE subtypes. |
| PC-24956 |
PF-07038124 hydrochloride
PDE4B2 inhibitor
|
Idrebormilast hydrochloride (PF-07038124) is a highly potent, selective PDE4 inhibitor with IC50 of 0.5 nM for PDE4B2 in SPA assays. |
| PC-24217 |
TP-10
PDE10A inhibitor
|
TP-10 is a potent, selective inhibitor of cyclic nucleotide phosphodiesterase PDE10A with IC50 of 0.8 nM. |
| PC-23896 |
PDE7A inhibitor 26
PDE7A inhibitor
|
PDE7A inhibitor 26 is a potent, selective PDE7A inhibitor with IC50 of 3.7 nM, 54-fold selective over PDE7B. |
| PC-23575 |
Dipyridamole
PDE inhibitor, Ferroptosis inhibitor
|
Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor, also is a potent inhibitor of ferroptosis in pulmonary epithelial and endothelial cells, binds to and activates superoxide dismutase 1 (SOD1). |
| PC-23488 |
PDE8 inhibitor 15
PDE8 inhibitor
|
PDE8 inhibitor 15 is a potent, selective phosphodiesterase 8A (PDE8A) inhibitor with IC50 of 11 nM (PDE8A), high selectivity over other PDEs. |
| PC-23487 |
PDE8A inhibitor 3a
PDE8 inhibitor
|
PDE8A inhibitor 3a is a potent, selective phosphodiesterase 8A (PDE8A) inhibitor with IC50 of 10 nM, >220-fold selective over PDE1B, PDE3A, PDE5A1, PDE7A1, PDE9A2, and PDE11A4. |
| PC-23485 |
VP1.15
PDE7/GSK-3 inhibitor
|
VP1.15 is a potent, dual PDE7/GSK-3 inhibitor with IC50 of 1.1 (PDE7) and 1.95 uM (GSK-3), shows antipsychotic and cognitive capacities. |
| PC-23484 |
VP3.15 dihydrobromide
PDE7/GSK-3 inhibitor
|
VP3.15 dihydrobromide is a potent, oral bioavailable and CNS penetrant dual PDE7/GSK-3 inhibitor with IC50 of 1.59 uM (PDE7) and 0.88 uM (GSK-3). |
| PC-23481 |
BC8-15C
PDE11A inhibitor
|
BC8-15C is a potent, selective PDE11A inhibitor with IC50 of 0.08 uM in in vitro enzyme assays, also inhibits PDE4A with IC50 of 0.13 uM, shows little to no activity against PDE1, PDE2, PDE3, PDE5, PDE9, PDE10. |
| PC-23480 |
BC8-15
PDE4/PDE8 inhibitor
|
BC8-15 is a small molecule inhibitor of PDE4 and PDE8 with IC50 of 0.28 uM (PDE4A) and 0.22 uM (PDE8A), also displays significant activity against PDE10A and PDE11A (IC50=1.2-1.6 uM). |
