| Cat. No. |
Product Name |
Information |
| PC-47111 |
DSR-141562
PDE1 inhibitor
|
DSR-141562 (DSR141562) is a potent, selective orally available and brain-penetrant phosphodiesterase 1 (PDE1) inhibitor with IC50 of 97.6, 43.9 and 431.8 nM for human PDE1A, PDE1B and PDE1C, respectively. |
| PC-47068 |
TOP-N53
PDE5 inhibitor
|
TOP-N53 is a dual-acting nitric oxide (NO) donor and selective PDE5 inhibitor, potently inhibits PDE5 with IC50 of 1.6 nM. |
| PC-38810 |
Yonkenafil
PDE5 inhibitor
|
Yonkenafil (Tunodafil) is a potent, selective PDE5 inhibitor with IC50 of 2.0 nM. |
| PC-38701 |
PF-04957325
PDE8 inhibitor
|
PF-04957325 is a highly potent and selective PDE8 inhibitor with IC50 values of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively. |
| PC-38401 |
Irsenontrine
PDE9 inhibitor
|
Irsenontrine (E2027) is a potent, selective and orally active phosphodiesterase 9 (PDE9) inhibitor, reduces the degradation of cyclic GMP (cGMP) which is critical to signal transmission among cells, and helps maintain the concentration of cGMP in the brain. |
| PC-73431 |
Mufemilast
PDE4 inhibitor
|
Mufemilast (Hemay005) is a potent, selective, first-in-class PDE4 inhibitor with in vitro IC50 of 80-120 nM, exhibits comparable inhibitory activities to apremilast. |
| PC-73314 |
BAY2666605
PDE3A-SLFN12 inducer
|
BAY2666605 is a potent, small molecule PDE3A-SLFN12 complex inducer with EC50 of 7 nM. |
| PC-73022 |
PDE4 activator MR-L2
PDE4 activator
|
PDE4 activator MR-L2 (MR-L2) is a small-molecule PDE4 activator, phenocopies PKA-mediated activation of long PDE4 isoforms. |
| PC-72598 |
BVQ1814
PDE10A inhibitor
|
BVQ1814 (BVQ-1814) is a highly effective fluorescent probe targeting PDE10A with highly potent affinity (IC50=0.9 nM), >1000-fold subfamily selectivity. |
| PC-72597 |
CPL500036
PDE10A inhibitor
|
CPL500036 (CPL-500036) is a highly potent, selective and orally bioavailable PDE10A inhibitor with IC50 of 35 nM. |
| PC-72340 |
LY2775240
PDE4 inhibitor
|
LY2775240 (LY-2775240) is a highly selective, potent and orally active inhibitor of phosphodiesterase 4 (PDE4) with IC50 of 0.09/0.09/2.4/0.14 nM for PDE4A/B/C/D. |
| PC-72172 |
IMR-687
PDE9 inhibitor
|
IMR-687 (IMR687, Tovinontrine) is a novel, potent and selective phosphodiesterase-9 (PDE-9) inhibitor with IC50 of 8.19 nM and 9.99 nM against PDE9A1 and PDE9A2, respectively. |
