| Cat. No. |
Product Name |
Information |
| PC-23487 |
PDE8A inhibitor 3a
PDE8 inhibitor
|
PDE8A inhibitor 3a is a potent, selective phosphodiesterase 8A (PDE8A) inhibitor with IC50 of 10 nM, >220-fold selective over PDE1B, PDE3A, PDE5A1, PDE7A1, PDE9A2, and PDE11A4. |
| PC-23485 |
VP1.15
PDE7/GSK-3 inhibitor
|
VP1.15 is a potent, dual PDE7/GSK-3 inhibitor with IC50 of 1.1 (PDE7) and 1.95 uM (GSK-3), shows antipsychotic and cognitive capacities. |
| PC-23484 |
VP3.15 dihydrobromide
PDE7/GSK-3 inhibitor
|
VP3.15 dihydrobromide is a potent, oral bioavailable and CNS penetrant dual PDE7/GSK-3 inhibitor with IC50 of 1.59 uM (PDE7) and 0.88 uM (GSK-3). |
| PC-23482 |
BC11-38
PDE11 inhibitor
|
BC11-38 is a potent and selective PDE11 inhibitor with IC50 of 0.28 uM, without acitivity against PDE1-10. |
| PC-23481 |
BC8-15C
PDE11A inhibitor
|
BC8-15C is a potent, selective PDE11A inhibitor with IC50 of 0.08 uM in in vitro enzyme assays, also inhibits PDE4A with IC50 of 0.13 uM, shows little to no activity against PDE1, PDE2, PDE3, PDE5, PDE9, PDE10. |
| PC-23480 |
BC8-15
PDE4/PDE8 inhibitor
|
BC8-15 is a small molecule inhibitor of PDE4 and PDE8 with IC50 of 0.28 uM (PDE4A) and 0.22 uM (PDE8A), also displays significant activity against PDE10A and PDE11A (IC50=1.2-1.6 uM). |
| PC-23410 |
PDE1 inhibitor 3f
PDE1 inhibitor
|
PDE1 inhibitor 3f is a potent, selective PDE1 inhibitor with IC50 of 11 nM, >24-fold selectivity over other PDEs, shows antifibrotic effects in vivo and in vitro. |
| PC-23407 |
Vardenafil
PDE5 inhibitor
|
Vardenafil is a potent, selective and orally active inhibitor of phosphodiesterase-5 (PDE5), inhibits the hydrolysis of cGMP by PDE5 with IC50 of 0.7 nM. |
| PC-23406 |
RF26
PDE5 inhibitor
|
RF26 (Compound d12) is a highly potent and selective PDE5 inhibitor with IC50 of 1 nM, three times more potent than sildenafil and more selective with a selectivity index of >10,000-fold against all other PDE isozymes. |
| PC-23243 |
Senazodan hydrochloride
PDE3 inhibitor
|
Senazodan (MCI-154) hydrochloride is a small molecule Ca2+-sensitiser and PDE3 inhibitor, exerts positive inotropic and chronotropic effects by binding directly to troponin C. |
| PC-23242 |
Pimobendan
PDE3 inhibitor
|
Pimobendan (UD-CG115) is an oral Ca2+-sensitiser and PDE3 inhibitor (IC50=320 nM). |
| PC-23191 |
PDE11A4 inhibitor 14b
PDE11A4 inhibitor
|
PDE11A4 inhibitor 14b is a potent, selective PDE11A4 inhibitor with IC50 of 53 nM, cAMP EC50 of 4.3 uM. |
