| Cat. No. |
Product Name |
Information |
| PC-25896 |
GSK4394835A
PDE3B inhibitor
|
GSK4394835A is a selective PDE3B inhibitor with pIC50 of 6.2, >20-fold selective over PDE3A. |
| PC-25743 |
Icariin
PDE5 inhibitor, PPARα activator
|
Icariin is a flavonol glycoside that inhibits PDE5 and PDE4 activities with IC50 of 432 nM and 73.50 μM, respectively, also is a PPARα activator, also is a small-molecule inducer that promotes G3BP1-driven biomolecular condensate formation, interacts with the N-terminal nuclear transport factor 2-like (NTF2L) domain of G3BP1. |
| PC-25667 |
Zardaverine
PDE3/4 inhibitor
|
Zardaverinea is a potent, specific PDE III/IV (PDE3/4) inhibitor, inhibits PDE III from human platelets and the rolipram-inhibitable PDE IV from canine trachea and human polymorphonuclear (PMN) cells with IC50 of 0.58, 0.79 and 0.17uM, respectively. |
| PC-25665 |
Nauclefine
PDE3A-SLFN12 inducer
|
Nauclefine is an indole alkaloid natural productthat binds PDE3A but does not inhibit the PDE3A's phosphodiesterase activity, induces apoptosis of diverse cancer cells via a PDE3A-SLFN12 dependent death pathway. |
| PC-25639 |
Anagrelide
PDE3 inhibitor
|
Anagrelide (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) with IC50 of 36 nM, inhibits platelet aggregation and bone marrow megakaryocytopoiesis. |
| PC-25390 |
PDE1 inhibitor 4b
PDE1 inhibitor
|
PDE1 inhibitor 4b is a potent, highly selective PDE1 inhibitor with IC50 of 5 nM, >147-fold selective over other PDEs, exhibits good antipulmonary fibrosis effects both in vitro and in vivo by suppressing the TGF-β/Smad and MAPK signaling pathway. |
| PC-25123 |
ENPP1 inhibitor 31
ENPP1 inhibitor
|
ENPP1 inhibitor 31 is a highly potent ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1, PC-1) inhibitor with IC50 of 14.68 nM, effectively activates the STING pathway in cell lines. |
| PC-25039 |
Davalomilast
PDE4 inhibitor
|
Davalomilast is a potent, selective PDE4 inhibitor with anti-inflammatory activity. |
| PC-25004 |
OMS824
PDE10 inhibitor
|
OMS824 (OMS-824) is a potent, selective phosphodiesterase 10 (PDE10) inhibitor. |
| PC-25003 |
PDE10A inhibitor 3e
PDE10A inhibitor
|
PDE10A inhibitor 3e is a potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 6.5 nM, >95-fold selective over other PDEs. |
| PC-25002 |
Ibudilast
PDE inhibitor
|
Ibudilast (KC-404, AV-411, MN-166) is a neuroimmune modulator which selectively inhibits phosphodiesterases (PDE) 3, PDE4, PDE10, and PDE11, shows platelet anti-aggregatory effects. |
| PC-24966 |
AWD 12-281
PDE4 inhibitor
|
AWD 12-281 (GW 842470) is a potent, orally active and highly selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 9.7 nM. |
