| Cat. No. |
Product Name |
Information |
| PC-24966 |
AWD 12-281
PDE4 inhibitor
|
AWD 12-281 (GW 842470) is a potent, orally active and highly selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 9.7 nM. |
| PC-24956 |
PF-07038124 hydrochloride
PDE4B2 inhibitor
|
Idrebormilast hydrochloride (PF-07038124) is a highly potent, selective PDE4 inhibitor with IC50 of 0.5 nM for PDE4B2 in SPA assays. |
| PC-24217 |
TP-10
PDE10A inhibitor
|
TP-10 is a potent, selective inhibitor of cyclic nucleotide phosphodiesterase PDE10A with IC50 of 0.8 nM. |
| PC-23488 |
PDE8 inhibitor 15
PDE8 inhibitor
|
PDE8 inhibitor 15 is a potent, selective phosphodiesterase 8A (PDE8A) inhibitor with IC50 of 11 nM (PDE8A), high selectivity over other PDEs. |
| PC-23484 |
VP3.15 dihydrobromide
PDE7/GSK-3 inhibitor
|
VP3.15 dihydrobromide is a potent, oral bioavailable and CNS penetrant dual PDE7/GSK-3 inhibitor with IC50 of 1.59 uM (PDE7) and 0.88 uM (GSK-3). |
| PC-23481 |
BC8-15C
PDE11A inhibitor
|
BC8-15C is a potent, selective PDE11A inhibitor with IC50 of 0.08 uM in in vitro enzyme assays, also inhibits PDE4A with IC50 of 0.13 uM, shows little to no activity against PDE1, PDE2, PDE3, PDE5, PDE9, PDE10. |
| PC-23480 |
BC8-15
PDE4/PDE8 inhibitor
|
BC8-15 is a small molecule inhibitor of PDE4 and PDE8 with IC50 of 0.28 uM (PDE4A) and 0.22 uM (PDE8A), also displays significant activity against PDE10A and PDE11A (IC50=1.2-1.6 uM). |
| PC-23410 |
PDE1 inhibitor 3f
PDE1 inhibitor
|
PDE1 inhibitor 3f is a potent, selective PDE1 inhibitor with IC50 of 11 nM, >24-fold selectivity over other PDEs, shows antifibrotic effects in vivo and in vitro. |
| PC-23407 |
Vardenafil
PDE5 inhibitor
|
Vardenafil is a potent, selective and orally active inhibitor of phosphodiesterase-5 (PDE5), inhibits the hydrolysis of cGMP by PDE5 with IC50 of 0.7 nM. |
| PC-23243 |
Senazodan hydrochloride
PDE3 inhibitor
|
Senazodan (MCI-154) hydrochloride is a small molecule Ca2+-sensitiser and PDE3 inhibitor, exerts positive inotropic and chronotropic effects by binding directly to troponin C. |
| PC-23242 |
Pimobendan
PDE3 inhibitor
|
Pimobendan (UD-CG115) is an oral Ca2+-sensitiser and PDE3 inhibitor (IC50=320 nM). |
| PC-22654 |
PDE4B/PDE5A inhibitor MDL3
PDE4B/PDE5A inhibitor
|
MDL3 is a potent, dual inhibitor of PDE4B and PDE5A, ameliorates pathophysiological signs and symptoms of liver injury and inflammation. |
