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Cat. No. Product Name Information
PC-21517

PDE4B inhibitor A-33

PDE4B inhibitor

PDE4B inhibitor A-33 is a potent, selective inhibitor of PDE4B with IC50 of 15 nM, >100-fold selective over PDE4D.
PC-20471

PDE4 inhibitor Compound A

PDE4B2 inhibitor

PDE4 inhibitor Compound A is a potent, highly selective PDE4 inhibitor with IC50 of 1.1 nM (PDE4B2), weakly inhibits PDE3 (IC50=150 nM) and does not inhibit other PDE subtypes.
PC-20038

Gemlapodect

PDE10A inhibitor

Gemlapodect (NOE-105) is a potent, selective PDE10A inhibitor with a potential therapeutic effect for the treatment of COFD.
PC-49676

BI 1015550

PDE4B inhibitor

BI 1015550 (Nerandomilast, VRN024219) is a potent, selective PDE4B inhibitor that preferentially inhibits hydrolysis of cAMP by PDE4B with IC50 of 10 nM, weakly inhibits PDE4A/4C/4D (IC50=248/8700/91 nM, respectively).
PC-49587

Orismilast

PDE4 inhibitor

Orismilast (LEO-32731) is a potent, selective, second generation PDE4 inhibitor with IC50 values of 3-52 nM for PDE4A/4B/4D subtype splice variants.
PC-49573

CRD733

PDE9A inhibitor

CRD733 (ASP4901) is a potent, selective cGMP-specific PDE9 (phosphodiesterase 9) inhibitor.
PC-49572

BAY-7081

PDE9A inhibitor

BAY-7801 (BAY7801) is a potent, selective, and orally bioavailable PDE9A inhibitor with IC50 of 15 nM (human PDE9A), 49-fold selectivity over PDE1.
PC-49494

MK-8189

PDE10A inhibitor

MK-8189 (MK8189) is a highly potent, selective PDE10A inhibitor with Ki of 29 pM, 500,000-fold selectivity over the other PDE enzyme families (PDE1-PDE11).
PC-49420

MCI-030

PDE10 inhibitor

MCI-030 (ADT 061) is a potent, selective PDE10 inhibitor, inhibits recombinant PDE10 using cGMP as a substrate with IC50 of 0.3 uM.
PC-49288

TPN171

PDE5 inhibitor

TPN171 (TPN-171) is a highly potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 0.62 nM, 32-fold selectivity over PDE6.
PC-47111

DSR-141562

PDE1 inhibitor

DSR-141562 (DSR141562) is a potent, selective orally available and brain-penetrant phosphodiesterase 1 (PDE1) inhibitor with IC50 of 97.6, 43.9 and 431.8 nM for human PDE1A, PDE1B and PDE1C, respectively.
PC-47068

TOP-N53

PDE5 inhibitor

TOP-N53 is a dual-acting nitric oxide (NO) donor and selective PDE5 inhibitor, potently inhibits PDE5 with IC50 of 1.6 nM.

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