| Cat. No. |
Product Name |
Information |
| PC-38401 |
Irsenontrine
PDE9 inhibitor
|
Irsenontrine (E2027) is a potent, selective and orally active phosphodiesterase 9 (PDE9) inhibitor, reduces the degradation of cyclic GMP (cGMP) which is critical to signal transmission among cells, and helps maintain the concentration of cGMP in the brain. |
| PC-73431 |
Mufemilast
PDE4 inhibitor
|
Mufemilast (Hemay005) is a potent, selective, first-in-class PDE4 inhibitor with in vitro IC50 of 80-120 nM, exhibits comparable inhibitory activities to apremilast. |
| PC-73314 |
BAY2666605
PDE3A-SLFN12 inducer
|
BAY2666605 is a potent, small molecule PDE3A-SLFN12 complex inducer with EC50 of 7 nM. |
| PC-73022 |
PDE4 activator MR-L2
PDE4 activator
|
PDE4 activator MR-L2 (MR-L2) is a small-molecule PDE4 activator, phenocopies PKA-mediated activation of long PDE4 isoforms. |
| PC-72598 |
BVQ1814
PDE10A inhibitor
|
BVQ1814 (BVQ-1814) is a highly effective fluorescent probe targeting PDE10A with highly potent affinity (IC50=0.9 nM), >1000-fold subfamily selectivity. |
| PC-72597 |
CPL500036
PDE10A inhibitor
|
CPL500036 (CPL-500036) is a highly potent, selective and orally bioavailable PDE10A inhibitor with IC50 of 35 nM. |
| PC-72340 |
LY2775240
PDE4 inhibitor
|
LY2775240 (LY-2775240) is a highly selective, potent and orally active inhibitor of phosphodiesterase 4 (PDE4) with IC50 of 0.09/0.09/2.4/0.14 nM for PDE4A/B/C/D. |
| PC-72237 |
Myricetin
ENPP1 inhibitor
|
Myricetin (Myricetol, Myricitin) is a flavonoid compound with antioxidant properties, inhibits ENPP1 enzymatic activity with IC50 of 4.8 uM. |
| PC-72236 |
STF-1084
ENPP1 inhibitor
|
STF-1084 (STF1084) is a potent, cell impermeable, specific, stable, and non-toxic ENPP1 inhibitor with Ki,app of 110 nM (in vitro 32P-cGAMP TLC assay), and cellular IC50 of 340 nM. |
| PC-72172 |
IMR-687
PDE9 inhibitor
|
IMR-687 (IMR687, Tovinontrine) is a novel, potent and selective phosphodiesterase-9 (PDE-9) inhibitor with IC50 of 8.19 nM and 9.99 nM against PDE9A1 and PDE9A2, respectively. |
| PC-72100 |
AA6216
PDE4 inhibitor
|
AA6216 (AA 6216) is novel potent, selective PDE4 inhibitor with IC50 of 0.63 nM. |
| PC-38280 |
STF-1623
ENPP1 inhibitor
|
STF-1623 (ENPP1 inhibitor 32) is a potent, cell-impermeable small molecule inhibitor of ENPP1 with Ki of < 2 nM, IC50 of 0.6 and 0.4 nM for human and mouse ENPP1 respectively. |
