| Cat. No. |
Product Name |
Information |
| PC-23575 |
Dipyridamole
PDE inhibitor, Ferroptosis inhibitor
|
Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor, also is a potent inhibitor of ferroptosis in pulmonary epithelial and endothelial cells, binds to and activates superoxide dismutase 1 (SOD1). |
| PC-23567 |
ENPP1 inhibitor VIR3
ENPP1 inhibitor
|
VIR3 is a potent, orally bioavailable Enpp1 with IC50 of <0.75 nM for ENPP1 cGAMP hydrolysis activity inhibition in in vitro assays. |
| PC-23487 |
PDE8A inhibitor 3a
PDE8 inhibitor
|
PDE8A inhibitor 3a is a potent, selective phosphodiesterase 8A (PDE8A) inhibitor with IC50 of 10 nM, >220-fold selective over PDE1B, PDE3A, PDE5A1, PDE7A1, PDE9A2, and PDE11A4. |
| PC-23485 |
VP1.15
PDE7/GSK-3 inhibitor
|
VP1.15 is a potent, dual PDE7/GSK-3 inhibitor with IC50 of 1.1 (PDE7) and 1.95 uM (GSK-3), shows antipsychotic and cognitive capacities. |
| PC-23482 |
BC11-38
PDE11 inhibitor
|
BC11-38 is a potent and selective PDE11 inhibitor with IC50 of 0.28 uM, without acitivity against PDE1-10. |
| PC-23406 |
RF26
PDE5 inhibitor
|
RF26 (Compound d12) is a highly potent and selective PDE5 inhibitor with IC50 of 1 nM, three times more potent than sildenafil and more selective with a selectivity index of >10,000-fold against all other PDE isozymes. |
| PC-23191 |
PDE11A4 inhibitor 14b
PDE11A4 inhibitor
|
SMQ-03-20 (PDE11A4 inhibitor 14b) is a potent, selective, brain-penetrant PDE11A4 inhibitor with IC50 of 53 nM, cAMP EC50 of 4.3 uM. |
| PC-21517 |
PDE4B inhibitor A-33
PDE4B inhibitor
|
PDE4B inhibitor A-33 is a potent, selective inhibitor of PDE4B with IC50 of 15 nM, >100-fold selective over PDE4D. |
| PC-21464 |
ME3183
PDE4 inhibitor
|
Morcamilast (ME3183) is a potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 2.33, 1.28 and 1.63 nM for PDE4B1, PDE4A1A and PDE4D2 respectively. |
| PC-21326 |
ENPP1 inhibitor 29f
ENPP1 inhibitor
|
ENPP1 inhibitor 29f is a potent, orally active inhibitor of ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), inhibits the cGAMP hydrolysis by ENPP1 in vitro with IC50 of 68 nM. |
| PC-21325 |
MV-658
ENPP1 inhibitor
|
MV658 (ENPP-1-IN-1) is a potent small molecule ENPP1 inhibitor (IC50= 11 nM) as immune modulator.r. |
| PC-21270 |
SMQ-02-57
PDE11A4 inhibitor
|
SMQ-02-57 (PDE11A4 inhibitor 23b) is a potent, selective PDE11A4 inhibitor with IC50 of 12 nM. |
