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Request The Product List ofPhosphodiesterase (PDE) Phosphodiesterase (PDE)

Cat. No. Product Name Information
PC-72100

AA6216

PDE4 inhibitor

AA6216 (AA 6216) is novel potent, selective PDE4 inhibitor with IC50 of 0.63 nM.
PC-35906

D159153

PDE4 inhibitor

D159153 (D-159153) is a novel potent, allosteric inhibitor of PDE4 with cellular IC50 of 28.5 and 6.6 nM for PDE4B1 and PDE4D3, respectively.
PC-35904

BPN14770

PDE4D inhibitor

Zatolmilast (BPN14770) is an allosteric inhibitor of phosphodiesterase 4D (PDE4D) with IC50 of 7.8 and 7.4 nM for human PDE4D7 and PDE4D3 respectively.
PC-35839

PDE2 inhibitor 4

PDE2 inhibitor

PDE2 inhibitor 4 is a potent, selective, orally available inhibitor of PDE2 with IC50 of 2 nM, displays high selectivity versus other PDE isoforms.
PC-35833

PF-04449613

PDE9 inhibitor

PF-04449613 (PF-9613, PF04449613, PF 04449613) is a potent and selective inhibitor of PDE9 with IC50 of 22 nM, >50-fold selective over PDE1C (IC50>1000 nM).
PC-43473

Vinpocetine

PDE1 inhibitor

Vinpocetine (Ethyl apovincaminate) is a synthetic derivative of the vinca alkaloid vincamine, selectively inhibits PDE1 in isolated rabbit aorta with IC50 of 21 uM.
PC-63527

PF-04827736

PDE1 inhibitor

PF-04827736 ((S)-PF-04677490) is a potent, selective PDE1 inhibitor with IC50 of 42, 9.1 and 38 nM for PDE1A, PDE1B and PDE1C, respectively.
PC-63526

PF-04677490

PDE1 inhibitor

PF-04677490 is a potent, selective PDE1 inhibitor with IC50 of 21 nM for PDE1B.
PC-63331

MPPA

sEH/PDE4 inhibitor

MPPA is a potent, orally bioavailable sEH/PDE4 dual inhibitor with IC50 of 2.1 nM and 8.1 nM for hsEH and PDE4, respectively.
PC-63306

PDE10A-IN-32

PDE10A inhibitor

PDE10A-IN-32 is a potent, highly selective, brain penetrant PDE10A inhibitor with IC50 of 0.14 nM, displays no significant activity against other PDEs (IC50>1,000 nM).
PC-43068

ITI214

PDE1 inhibitor

ITI-214 is a potent, selective, orally active phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms.
PC-43067

ITI214 free base

PDE1 inhibitor

ITI-214 is a potent, selective phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms.

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