| Cat. No. |
Product Name |
Information |
| PC-20681 |
Roflumilast
PDE4 inhibitor
|
Roflumilast (APTA-2217) is a potent, selective, orally active PDE4 inhibitor with IC50 of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively. |
| PC-35839 |
PDE2 inhibitor 4
|
PDE2 inhibitor 4 is a potent, selective, orally available inhibitor of PDE2 with IC50 of 2 nM, displays high selectivity versus other PDE isoforms. |
| PC-63306 |
PDE10A-IN-32
|
PDE10A-IN-32 is a potent, highly selective, brain penetrant PDE10A inhibitor with IC50 of 0.14 nM, displays no significant activity against other PDEs (IC50>1,000 nM).. |
| PC-63121 |
PDE4D-IN-26b
|
PDE4D-IN-26b is a potent, highly selective PDE4D inhibitor with IC50 of 0.6 nM, displays 75-fold lower activity against the PDE4A, B, and C subtypes, also exhibits 18,000-fold decreased potency against other PDE family members. |
| PC-62885 |
(R)-DNMDP
|
(R)-DNMDP (DNMDP R-form) is the R-form of is DNMDP, which is a potent and selective cancer cell cytotoxic agent that binds to PDE3A, promotes an interaction between PDE3A and Schlafen 12 (SLFN12).. |
| PC-62884 |
Trequinsin hydrochloride
|
Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM), inhibits arachidonic acid-induced aggregation of human platelets with IC50 of 50 pM. |
| PC-62737 |
PDE10A-IN-31
|
PDE10A-IN-31 is a potent, highly selective PDE10A inhibitor with IC50 of 2 nM for both rPDE10A and hPDE10A. |
| PC-62700 |
PyP-1
|
PyP-1 is a potent, highly selective, and orally bioavailable PDE10A inhibitor with Ki of 0.23 nM. |
| PC-61897 |
UK-369003
|
UK-369003 (Gisadenafil besylate) is a novel, potent, selective, orally bioavailable PDE5 inhibitor with IC50 of 1.23 nM, displays 117-fold selectivity over PDE6. |
| PC-61858 |
PF-03049423
|
PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM. |
| PC-61617 |
GSK-256066
|
GSK-256066 is a highly potent, selective PDE4B inhibitor with pIC50 of 11.1, apparent IC50 of 3.2 pM, inhibits PDE4 isoforms A-D with equal affinity. |
| PC-61348 |
PQ-10
|
A potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM. |
