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Request The Product List ofPhosphodiesterase (PDE) Phosphodiesterase (PDE)

Cat. No. Product Name Information
PC-22654

PDE4B/PDE5A inhibitor MDL3

PDE4B/PDE5A inhibitor

MDL3 is a potent, dual inhibitor of PDE4B and PDE5A, ameliorates pathophysiological signs and symptoms of liver injury and inflammation.
PC-22040

YM976

PDE4 inhibitor

YM976 is a potent, selective phosphodiesterase type 4 (PDE4) inhibitor with IC50 of 2.2 nM against PDE4 purified from human peripheral leukocytes.
PC-22039

BAY 60-7550

PDE2 inhibitor

BAY 60-7550 (Bay60-7550) is a potent and selective PDE2 inhibitor with Ki of 3.8 nM, IC50 of 4.7 nM (human PDE2A), and 2.0 nM (bovine purified PDE2).
PC-22038

CT-2450

PDE4 inhibitor

CT-2450 is a potent, selective phosphodiesterase (PDE IV, PDE4) inhibitor.
PC-21899

Anagrelide hydrochloride

PDE3 inhibitor

Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) with IC50 of 36 nM, inhibits platelet aggregation and bone marrow megakaryocytopoiesis.
PC-21518

D159687

PDE4D inhibitor

D159687 is a selective, negative allosteric modulator (inhibitor) of PDE4D with IC50 of 1.9 nM, >1,000 time more selective against PDE4 compared with other PDEs.
PC-21464

ME3183

PDE4 inhibitor

ME3183 is a potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 2.33, 1.28 and 1.63 nM for PDE4B1, PDE4A1A and PDE4D2 respectively.
PC-21270

PDE11A4 inhibitor 23b

PDE11A4 inhibitor

PDE11A4 inhibitor 23b is a potent, selective PDE11A4 inhibitor with IC50 of 12 nM.
PC-20981

PDE12 inhibitor Compound 1

PDE12 inhibitor

PDE12 inhibitor Compound 1 is a potent, selective inhibitor of phosphodiesterase 12 (PDE12) with pIC50 of 9.1 and Ki of 17.5 nM, >1000-fold selectivity over EEP nuclease family member CNOT6.
PC-20974

CC-11050

PDE4 inhibitor

Dovramilast (CC-11050) is a potent and orally active phosphodiesterase 4 (PDE4) inhibitor, CC-11050 is a promising candidate for host directed therapy of patients with pulmonary TB.
PC-20916

Sildenafil

PDE5 inhibitor

Sildenafil (UK-92480) is a potent, selective, orally active phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 3.9 nM.
PC-20682

PF-07038124

PDE4 inhibitor

PF-07038124 (PF 07038124) is a highly potent, selective PDE4 inhibitor with IC50 of 0.5 nM for PDE4B2 in SPA assays, inhibits cytokines release of IL-4, IL-13 and IFNy from human PBMCs stimulated with PHA-L with IC50 of 135, 4.1, and 1.06 nM, respectively.

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