| Cat. No. |
Product Name |
Information |
| PC-60875 |
PDE12-IN-3
PDE12 inhibitor
|
PDE12-IN-3 is a potent phosphodiesterase 12 (PDE12) with Ki of 17.5 nM, with no activity for related enzyme CNOT6 (Ki>10 uM). |
| PC-60796 |
JNJ-42314415
PDE10A inhibitor
|
JNJ-42314415(JNJ42314415) is a potent, selective, centrally active phosphodiesterase 10A (PDE10A) inhibitor with Ki of 35 nM for human recombinant PDE10A. |
| PC-60726 |
UK-500001
PDE4 inhibitor
|
UK-500001 is a potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 26.1, 22.8, 21 and 0.28 nM for PDE4A4, PDE4B2, PDE4C2 and PDE4D3, respectively. |
| PC-60725 |
CHF6001
PDE4 inhibitor
|
Tanimilast (CHF6001) is a novel, highly potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 0.026 nM. |
| PC-60657 |
GSK356278
PDE4 inhibitor
|
GSK356278 is a potent, selective, brain-penetrant and orally bioavailable phosphodiesterase 4 (PDE4) inhibitor with pIC50 of 8.8 (PDE4B). |
| PC-60651 |
AMG 580
PDE10A inhibitor
|
AMG 580 (AMG580) is a novel potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 0.13 nM. |
| PC-60608 |
(S)-C33
PDE9A inhibitor
|
(S)-C33 is a potent, selective PDE9A inhibitor with IC50 of 11 nM, >45-fold selectivity over other PDE isoforms. |
| PC-60564 |
PF 05180999
PDE2A inhibitor
|
PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM. |
| PC-60563 |
TAK-915
PDE2A inhibitor
|
TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM. |
| PC-60496 |
AMG-579
PDE10A inhibitor
|
AMG-579 (AMG579) is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM. |
| PC-60365 |
PDM-631
PDE2A inhibitor
|
PDM-631 is a potent, selective, brain-penetrable and orally active PDE2A inhibitor with IC50 of 1.5 and 4.2 nM for human and rat PDE2A, respectively. |
| PC-60220 |
RPL-554
PDE3/PDE4 inhibitor
|
RPL-554 (Ensifentrine, LS-193855, RPL554) is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively. |
