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Request The Product List ofPhosphodiesterase (PDE) Phosphodiesterase (PDE)

Cat. No. Product Name Information
PC-60796

JNJ-42314415

PDE10A inhibitor

JNJ-42314415(JNJ42314415) is a potent, selective, centrally active phosphodiesterase 10A (PDE10A) inhibitor with Ki of 35 nM for human recombinant PDE10A.
PC-60726

UK-500001

PDE4 inhibitor

UK-500001 is a potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 26.1, 22.8, 21 and 0.28 nM for PDE4A4, PDE4B2, PDE4C2 and PDE4D3, respectively.
PC-60725

CHF6001

PDE4 inhibitor

Tanimilast (CHF6001) is a novel, highly potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 0.026 nM.
PC-60657

GSK356278

PDE4 inhibitor

GSK356278 is a potent, selective, brain-penetrant and orally bioavailable phosphodiesterase 4 (PDE4) inhibitor with pIC50 of 8.8 (PDE4B).
PC-60651

AMG 580

PDE10A inhibitor

AMG 580 (AMG580) is a novel potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 0.13 nM.
PC-60608

(S)-C33

PDE9A inhibitor

(S)-C33 is a potent, selective PDE9A inhibitor with IC50 of 11 nM, >45-fold selectivity over other PDE isoforms.
PC-60564

PF 05180999

PDE2A inhibitor

PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.
PC-60563

TAK-915

PDE2A inhibitor

TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM.
PC-60496

AMG-579

PDE10A inhibitor

AMG-579 (AMG579) is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM.
PC-60365

PDM-631

PDE2A inhibitor

PDM-631 is a potent, selective, brain-penetrable and orally active PDE2A inhibitor with IC50 of 1.5 and 4.2 nM for human and rat PDE2A, respectively.
PC-60220

RPL-554

PDE3/PDE4 inhibitor

RPL-554 (Ensifentrine, LS-193855, RPL554) is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively.
PC-60211

GS-5759

PDE4 inhibitor, β2-adrenoceptor agonist

GS-5759 is a novel bifunctional PDE4 inhibitor (IC50=5 nM) and long acting β2-adrenoceptor agonist (EC50=8 nM).

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