| Cat. No. |
Product Name |
Information |
| PC-62897 |
CI-1044
PDE4 inhibitor
|
CI-1044 is a potent, selective and orally bioavailable PDE4 inhibitor with IC50 of 0.27 uM, displays high selectivity for PDE4 versus PDE1/3/5, and no PDE4 subtype (4A-D) selectivities. |
| PC-62528 |
PF-06815189
PDE2 inhibitor
|
PF-06815189 is a potent, selective phosphodiesterase 2 (PDE2) inhibitor with IC50 of 0.4 nM, >1,000-fold selectivity over PDE5. |
| PC-62220 |
DNMDP
PDE3A-SLFN12 activator
|
DNMDP is a small molecule that induces complex formation between phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12), specifically kills cancer cells with high levels of PDE3A and SLFN12 expression. |
| PC-62180 |
Eggmanone
PDE4 inhibitor
|
Eggmanone is a potent, selective inhibitor of PDE4 with (IC50=72 nM) that antagonizes the Hedgehog signaling pathway. |
| PC-62068 |
NCGC00071837
PDE4 inhibitor
|
NCGC00071837 (PDE4-IN-5A) is a potent, selective PDE4 inhibitor with IC50 of 24 and 18 nM for PDE4A and PDE4D, respectively, weak inhibition for PDE4B (IC50=0.54 uM) and inactive for PDE1/3/5/7/9/10/11. |
| PC-61387 |
Lotamilast
PDE4 inhibitor
|
Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM. |
| PC-61372 |
Difamilast
PDE4B inhibitor
|
Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM). |
| PC-61347 |
TC-E 5005
PDE10A inhibitor
|
TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 of 7.28 nM. |
| PC-61345 |
ADT-094
PDE5/PDE10 inhibitor
|
ADT-094 (ADT094) is a novel, non-COX inhibitory sulindac derivative that potently and selectivity inhibits colon tumor cell growth by inhibiting PDE5 and PDE10 with IC50 of 2.4 uM and 0.5 uM, respectively. |
| PC-61343 |
Lu AF-58027
PDE1 inhibitor
|
Lu AF-58027 is a potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively. |
| PC-61341 |
PF-04822163
PDE1 inhibitor
|
PF-04822163 is a potent and selective, CNS-penetrant PDE1 inhibitor with IC50 of 2.4 nM for PDE1B. |
| PC-61339 |
BRL-50481
PDE7 inhibitor
|
BRL-50481 (BRL50481) is a potent and selective, competitive PDE7 inhibitor with Ki of 180 nM, displays >200-fold selectivity over PDE1B/1C/2/3/4A/5. |
