| Cat. No. |
Product Name |
Information |
| PC-63331 |
MPPA
sEH/PDE4 inhibitor
|
MPPA is a potent, orally bioavailable sEH/PDE4 dual inhibitor with IC50 of 2.1 nM and 8.1 nM for hsEH and PDE4, respectively. |
| PC-63306 |
PDE10A-IN-32
PDE10A inhibitor
|
PDE10A-IN-32 is a potent, highly selective, brain penetrant PDE10A inhibitor with IC50 of 0.14 nM, displays no significant activity against other PDEs (IC50>1,000 nM). |
| PC-43068 |
ITI-214
PDE1 inhibitor
|
ITI-214 (Lenrispodun) is a potent, selective, orally active phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms. |
| PC-43067 |
ITI214 free base
PDE1 inhibitor
|
ITI-214 is a potent, selective phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms. |
| PC-43051 |
TAK-063
PDE10A inhibitor
|
TAK-063 (Balipodect) is a highly potent, selective, orally active PDE10A inhibitor with IC50 of 0.3 nM, displays >15,000-fold selectivity over other PDE subtypes. |
| PC-42971 |
IBMX
PDEs inhibitor
|
IBMX (Isobutylmethylxanthine, Methylisobutylxanthine, NSC165960) is a broad-spectrum inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) with IC50 of 5-50 uM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11. |
| PC-42891 |
Apremilast
PDE4 inhibitor
|
Apremilast (CC-10004) is a potent, orally active PDE4 inhibitor with IC50 of 74 nM, inhibits TNF-α production in LPS-stimulated hPBMCs with IC50 of 77 nM. |
| PC-63121 |
PDE4D-IN-26b
PDE4D inhibitor
|
PDE4D-IN-26b is a potent, highly selective PDE4D inhibitor with IC50 of 0.6 nM, displays 75-fold lower activity against the PDE4A, B, and C subtypes, also exhibits 18,000-fold decreased potency against other PDE family members. |
| PC-63097 |
CDP-840 hydrochloride
PDE4 inhibitor
|
CDP-840 (CDP840. |
| PC-63096 |
CDP-840
PDE4 inhibitor
|
CDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast. |
| PC-63095 |
ONO-6126
PDE4 inhibitor
|
ONO-6126 is a potent and selective PDE4 inhibitor for the treatment of bronchial asthma and allergic conjunctivitis.. |
| PC-63094 |
Oglemilast
PDE4 inhibitor
|
Oglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively.. |
