| Cat. No. |
Product Name |
Information |
| PC-63089 |
Piclamilast
PDE4 inhibitor
|
Piclamilast (RP73401) is a potent and highly selective PDE4 inhibitor with IC50 of 1.2 nM. |
| PC-63088 |
HT-0712
PDE4 inhibitor
|
HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3, without effect on PDE1B, PDE3A, and PDE10A. |
| PC-63029 |
TPN729 maleate
PDE5 inhibitor
|
TPN729 maleate is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM. |
| PC-63028 |
TPN729
PDE5 inhibitor
|
TPN729 is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM, shows better selectivity profile 2.5 times higher than sildenafil against PDE6 and 500 times higher than tadalafil against PDE11. |
| PC-62973 |
FCPR03
PDE4 inhibitor
|
FCPR03 is a novel potent, selective PDE4 inhibitor with IC50 of 60, 31 and 47 nM for PDE4CAT (PDE4 catalytic domain), PDE4B1 and PDE4D7, respectively. |
| PC-62897 |
CI-1044
PDE4 inhibitor
|
CI-1044 is a potent, selective and orally bioavailable PDE4 inhibitor with IC50 of 0.27 uM, displays high selectivity for PDE4 versus PDE1/3/5, and no PDE4 subtype (4A-D) selectivities. |
| PC-62885 |
(R)-DNMDP
PDE3A inhibitor
|
(R)-DNMDP (DNMDP R-form) is the R-form of is DNMDP, which is a potent and selective cancer cell cytotoxic agent that binds to PDE3A, promotes an interaction between PDE3A and Schlafen 12 (SLFN12). |
| PC-62884 |
Trequinsin hydrochloride
PDE3 inhibitor
|
Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PDE3 IC50=250 pM), inhibits arachidonic acid-induced aggregation of human platelets with IC50 of 50 pM. |
| PC-62737 |
PDE10A-IN-31
PDE10A inhibitor
|
PDE10A-IN-31 is a potent, highly selective PDE10A inhibitor with IC50 of 2 nM for both rPDE10A and hPDE10A. |
| PC-62700 |
PyP-1
PDE10A inhibitor
|
PyP-1 is a potent, highly selective, and orally bioavailable PDE10A inhibitor with Ki of 0.23 nM. |
| PC-62528 |
PF-06815189
PDE2 inhibitor
|
PF-06815189 is a potent, selective phosphodiesterase 2 (PDE2) inhibitor with IC50 of 0.4 nM, >1,000-fold selectivity over PDE5. |
| PC-62220 |
DNMDP
PDE3A inhibitor
|
DNMDP is a small molecule that induces complex formation between phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12), specifically kills cancer cells with high levels of PDE3A and SLFN12 expression. |
