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Request The Product List ofPhosphodiesterase (PDE) Phosphodiesterase (PDE)

Cat. No. Product Name Information
PC-62180

Eggmanone

PDE4 inhibitor

Eggmanone is a potent, selective inhibitor of PDE4 with (IC50=72 nM) that antagonizes the Hedgehog signaling pathway.
PC-62068

NCGC00071837

PDE4 inhibitor

NCGC00071837 (PDE4-IN-5A) is a potent, selective PDE4 inhibitor with IC50 of 24 and 18 nM for PDE4A and PDE4D, respectively, weak inhibition for PDE4B (IC50=0.54 uM) and inactive for PDE1/3/5/7/9/10/11.
PC-61897

UK-369003

PDE5 inhibitor

UK-369003 (Gisadenafil besylate) is a novel, potent, selective, orally bioavailable PDE5 inhibitor with IC50 of 1.23 nM, displays 117-fold selectivity over PDE6.
PC-61858

PF-03049423

PDE5 inhibitor

PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM.
PC-61617

GSK256066

PDE4 inhibitor

GSK256066 is a highly potent, selective PDE4B inhibitor with pIC50 of 11.1, apparent IC50 of 3.2 pM, inhibits PDE4 isoforms A-D with equal affinity.
PC-61387

Lotamilast

PDE4 inhibitor

Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM.
PC-61372

Difamilast

PDE4B inhibitor

Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM).
PC-61348

PQ-10

PDE10A inhibitor

PQ-10 is a potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM.
PC-61347

TC-E 5005

PDE10A inhibitor

TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 of 7.28 nM.
PC-61346

BMS-843496

PDE10A inhibitor

BMS-843496 is a potent and selective PDE10A inhibitor with binding affinity (Kd) of 0.15 nM, IC50 of 2.11 nM.
PC-61345

ADT-094

PDE5/PDE10 inhibitor

ADT-094 (ADT094) is a novel, non-COX inhibitory sulindac derivative that potently and selectivity inhibits colon tumor cell growth by inhibiting PDE5 and PDE10 with IC50 of 2.4 uM and 0.5 uM, respectively.
PC-61344

MY-5445

PDE5 inhibitor

MY-5445 is a specific PDE5 inhibitor that inhibits human platelet aggregation induced by 3 uM ADP, 3 mg/ml of collagen and 100 ug/ml of arachidonic acid with IC50 of 0.07, 0.02 and 0.17 uM, respectively.

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