| Cat. No. |
Product Name |
Information |
| PC-22038 |
CT-2450
PDE4 inhibitor
|
CT-2450 is a potent, selective phosphodiesterase (PDE IV, PDE4) inhibitor. |
| PC-21899 |
Anagrelide hydrochloride
PDE3 inhibitor
|
Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) with IC50 of 36 nM, inhibits platelet aggregation and bone marrow megakaryocytopoiesis. |
| PC-21518 |
D159687
PDE4D inhibitor
|
D159687 is a selective, negative allosteric modulator (inhibitor) of PDE4D with IC50 of 1.9 nM, >1,000 time more selective against PDE4 compared with other PDEs. |
| PC-21464 |
ME3183
PDE4 inhibitor
|
ME3183 is a potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 2.33, 1.28 and 1.63 nM for PDE4B1, PDE4A1A and PDE4D2 respectively. |
| PC-21270 |
PDE11A4 inhibitor 23b
PDE11A4 inhibitor
|
PDE11A4 inhibitor 23b is a potent, selective PDE11A4 inhibitor with IC50 of 12 nM. |
| PC-20981 |
PDE12 inhibitor Compound 1
PDE12 inhibitor
|
PDE12 inhibitor Compound 1 is a potent, selective inhibitor of phosphodiesterase 12 (PDE12) with pIC50 of 9.1 and Ki of 17.5 nM, >1000-fold selectivity over EEP nuclease family member CNOT6. |
| PC-20974 |
CC-11050
PDE4 inhibitor
|
Dovramilast (CC-11050) is a potent and orally active phosphodiesterase 4 (PDE4) inhibitor, CC-11050 is a promising candidate for host directed therapy of patients with pulmonary TB. |
| PC-20916 |
Sildenafil
PDE5 inhibitor
|
Sildenafil (UK-92480) is a potent, selective, orally active phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 3.9 nM. |
| PC-20682 |
PF-07038124
PDE4 inhibitor
|
PF-07038124 (PF 07038124) is a highly potent, selective PDE4 inhibitor with IC50 of 0.5 nM for PDE4B2 in SPA assays, inhibits cytokines release of IL-4, IL-13 and IFNy from human PBMCs stimulated with PHA-L with IC50 of 135, 4.1, and 1.06 nM, respectively. |
| PC-20681 |
Roflumilast
PDE4 inhibitor
|
Roflumilast (APTA-2217) is a potent, selective, orally active PDE4 inhibitor with IC50 of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively. |
| PC-20471 |
PDE4 inhibitor Compound A
|
PDE4 inhibitor Compound A is a potent, highly selective PDE4 inhibitor with IC50 of 1.1 nM (PDE4B2), weakly inhibits PDE3 (IC50=150 nM) and does not inhibit other PDE subtypes. |
| PC-20038 |
Gemlapodect
PDE10A inhibitor
|
Gemlapodect (NOE-105) is a potent, selective PDE10A inhibitor with a potential therapeutic effect for the treatment of COFD. |
