| Cat. No. |
Product Name |
Information |
| PC-61343 |
Lu AF-58027
PDE1 inhibitor
|
Lu AF-58027 is a potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively. |
| PC-61342 |
PF-04471141 hydrochloride
PDE1 inhibitor
|
PF-04471141 hydrochloride is a potent and selective, CNS-penetrant PDE1 inhibitor with IC50 of 35 nM for PDE1B. |
| PC-61341 |
PF-04822163
PDE1 inhibitor
|
PF-04822163 is a potent and selective, CNS-penetrant PDE1 inhibitor with IC50 of 2.4 nM for PDE1B. |
| PC-61339 |
BRL-50481
PDE7 inhibitor
|
BRL-50481 (BRL50481) is a potent and selective, competitive PDE7 inhibitor with Ki of 180 nM, displays >200-fold selectivity over PDE1B/1C/2/3/4A/5. |
| PC-61338 |
Org-9935
PDE3 inhibitor
|
Org-9935 (Org9935) is a potent, selective PDE3 inhibitor with IC50 of 50 nM. |
| PC-61334 |
BAY 73-6691
PDE9 inhibitor
|
BAY 73-6691 is a potent and selective PDE9 inhibitor with IC50 of 55 nM and 100 nM for human and murine PDE9, respectively. |
| PC-61333 |
BC54
PDE4/7 inhibitor
|
BC54 is a potent and biologically-active PDE4/7 inhibitor with IC50 of 50-100 nM for PDE4A/B/D, and 140 nM for both PDE7A/B. |
| PC-70272 |
Zaprinast
PDE5/6 inhibitor, GPR35 agonist
|
Zaprinast (M&B 22948) is a potent, cGMP-specific phosphodiesterase inhibitor with IC50 of 0.5-0.76 and 0.15 uM for PDE5 and PDE6 respectively, also is an agonist for GPR35 (EC50=16/840 nM for rat/human GPR35). |
| PC-61126 |
PF-05085727
PDE2A inhibitor
|
PF-05085727 is a potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11. |
| PC-61085 |
CGH2466
p38 MAPK/PDE4 inhibitor
|
CGH2466 is a combined adenosine receptor antagonist, p38 MAPK and PDE4 inhibitor, inhibits A1, A2b and A3 receptor (IC50=19, 21 and 80 nM), p38α, p38β and PDE4D (IC50=87, 400 and 22 nM). |
| PC-60996 |
ASP9436
PDE10A inhibitor
|
ASP9436 (ASP-9436) is a potent, selective brain penetrant and orally active phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 8.0 nM, >420-fold selectivity over other PDE subtypes. |
| PC-60875 |
PDE12-IN-3
PDE12 inhibitor
|
PDE12-IN-3 is a potent phosphodiesterase 12 (PDE12) with Ki of 17.5 nM, with no activity for related enzyme CNOT6 (Ki>10 uM). |
