| Cat. No. |
Product Name |
Information |
| PC-25639 |
Anagrelide
PDE3 inhibitor
|
Anagrelide (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) with IC50 of 36 nM, inhibits platelet aggregation and bone marrow megakaryocytopoiesis. |
| PC-25390 |
PDE1 inhibitor 4b
PDE1 inhibitor
|
PDE1 inhibitor 4b is a potent, highly selective PDE1 inhibitor with IC50 of 5 nM, >147-fold selective over other PDEs, exhibits good antipulmonary fibrosis effects both in vitro and in vivo by suppressing the TGF-β/Smad and MAPK signaling pathway. |
| PC-25123 |
ENPP1 inhibitor 31
ENPP1 inhibitor
|
ENPP1 inhibitor 31 is a highly potent ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1, PC-1) inhibitor with IC50 of 14.68 nM, effectively activates the STING pathway in cell lines. |
| PC-25102 |
Vizenpistat
ENPP1 inhibitor
|
Vizenpistat is a potent, selective ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) inhibitor. |
| PC-25039 |
Davalomilast
PDE4 inhibitor
|
Davalomilast is a potent, selective PDE4 inhibitor with anti-inflammatory activity. |
| PC-25004 |
OMS824
PDE10 inhibitor
|
OMS824 (OMS-824) is a potent, selective phosphodiesterase 10 (PDE10) inhibitor. |
| PC-25003 |
PDE10A inhibitor 3e
PDE10A inhibitor
|
PDE10A inhibitor 3e is a potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 6.5 nM, >95-fold selective over other PDEs. |
| PC-25002 |
Ibudilast
PDE inhibitor
|
Ibudilast (KC-404, AV-411, MN-166) is a neuroimmune modulator which selectively inhibits phosphodiesterases (PDE) 3, PDE4, PDE10, and PDE11, shows platelet anti-aggregatory effects. |
| PC-24966 |
AWD 12-281
PDE4 inhibitor
|
AWD 12-281 (GW 842470) is a potent, orally active and highly selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 9.7 nM. |
| PC-24965 |
LEO 29102
PDE4 inhibitor
|
LEO 29102 is a potent, selective, and soft-drug PDE4 inhibitor with IC50 of 5 nM (PDE4D), inhibits TNFα release from hPBMCs stimulated with LPS with IC50 of 16 nM. |
| PC-24964 |
LEO 39652
PDE4 inhibitor
|
LEO 39652 is a potent, selective PDE4 inhibitor with IC50 of 1.2/1.2/3.0/3.8 nM for PDE4A/B/C/D respectively, selective over other PDE subtypes. |
| PC-24956 |
PF-07038124 hydrochloride
PDE4B2 inhibitor
|
Idrebormilast hydrochloride (PF-07038124) is a highly potent, selective PDE4 inhibitor with IC50 of 0.5 nM for PDE4B2 in SPA assays. |
