| Cat. No. |
Product Name |
Information |
| PC-22654 |
PDE4B/PDE5A inhibitor MDL3
PDE4B/PDE5A inhibitor
|
MDL3 is a potent, dual inhibitor of PDE4B and PDE5A, ameliorates pathophysiological signs and symptoms of liver injury and inflammation. |
| PC-22040 |
YM976
PDE4 inhibitor
|
YM976 is a potent, selective phosphodiesterase type 4 (PDE4) inhibitor with IC50 of 2.2 nM against PDE4 purified from human peripheral leukocytes. |
| PC-22039 |
BAY 60-7550
PDE2 inhibitor
|
BAY 60-7550 (Bay60-7550) is a potent and selective PDE2 inhibitor with Ki of 3.8 nM, IC50 of 4.7 nM (human PDE2A), and 2.0 nM (bovine purified PDE2). |
| PC-22038 |
CT-2450
PDE4 inhibitor
|
CT-2450 is a potent, selective phosphodiesterase (PDE IV, PDE4) inhibitor. |
| PC-21899 |
Anagrelide hydrochloride
PDE3 inhibitor
|
Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) with IC50 of 36 nM, inhibits platelet aggregation and bone marrow megakaryocytopoiesis. |
| PC-21518 |
D159687
PDE4D inhibitor
|
D159687 is a selective, negative allosteric modulator (inhibitor) of PDE4D with IC50 of 1.9 nM, >1,000 time more selective against PDE4 compared with other PDEs. |
| PC-21270 |
PDE11A4 inhibitor 23b
PDE11A4 inhibitor
|
PDE11A4 inhibitor 23b is a potent, selective PDE11A4 inhibitor with IC50 of 12 nM. |
| PC-20981 |
PDE12 inhibitor Compound 1
PDE12 inhibitor
|
PDE12 inhibitor Compound 1 is a potent, selective inhibitor of phosphodiesterase 12 (PDE12) with pIC50 of 9.1 and Ki of 17.5 nM, >1000-fold selectivity over EEP nuclease family member CNOT6. |
| PC-20974 |
CC-11050
PDE4 inhibitor
|
Dovramilast (CC-11050) is a potent and orally active phosphodiesterase 4 (PDE4) inhibitor, CC-11050 is a promising candidate for host directed therapy of patients with pulmonary TB. |
| PC-20682 |
PF-07038124
PDE4 inhibitor
|
PF-07038124 (PF 07038124) is a highly potent, selective PDE4 inhibitor with IC50 of 0.5 nM for PDE4B2 in SPA assays, inhibits cytokines release of IL-4, IL-13 and IFNy from human PBMCs stimulated with PHA-L with IC50 of 135, 4.1, and 1.06 nM, respectively. |
| PC-45081 |
(R)-(-)-Rolipram
|
A more active enantiomer of the PDE4 inhibitor rolipram. |
