| Cat. No. |
Product Name |
Information |
| PC-61346 |
BMS 843496
|
A potent and selective PDE10A inhibitor with binding affinity (Kd) of 0.15 nM, IC50 of 2.11 nM. |
| PC-61344 |
MY-5445
|
A specific PDE5 inhibitor that inhibits human platelet aggregation induced by 3 uM ADP, 3 mg/ml of collagen and 100 ug/ml of arachidonic acid with IC50 of 0.07, 0.02 and 0.17 uM, respectively. |
| PC-61342 |
PF-04471141 hydrochloride
|
A potent and selective, CNS-penetrant PDE1 inhibitor with IC50 of 35 nM for PDE1B.. |
| PC-61126 |
PF-05085727
|
A potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11. |
| PC-61085 |
CGH2466
|
A combined adenosine receptor antagonist, p38 MAPK and PDE4 inhibitor, inhibits A1, A2b and A3 receptor (IC50=19, 21 and 80 nM), p38α, p38β and PDE4D (IC50=87, 400 and 22 nM). |
| PC-60875 |
PDE12-IN-3
|
A potent phosphodiesterase 12 (PDE12) with Ki of 17.5 nM, with no activity for related enzyme CNOT6 (Ki>10 uM). |
| PC-60726 |
UK-500001
|
A potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 26.1, 22.8, 21 and 0.28 nM for PDE4A4, PDE4B2, PDE4C2 and PDE4D3, respectively.. |
| PC-60657 |
GSK 356278
|
A potent, selective, brain-penetrant and orally bioavailable phosphodiesterase 4 (PDE4) inhibitor with pIC50 of 8.8 (PDE4B). |
| PC-60608 |
(S)-C33
|
A novel potent, selective PDE9A inhibitor with IC50 of 11 nM, >45-fold selectivity over other PDE isoforms. |
| PC-60365 |
PDM-631
|
A novel potent, selective, brain-penetrable and orally active PDE2A inhibitor with IC50 of 1.5 and 4.2 nM for human and rat PDE2A, respectively. |
| PC-60211 |
GS-5759
|
A novel bifunctional PDE4 inhibitor (IC50=5 nM) and long acting β2-adrenoceptor agonist (EC50=8 nM). |
| PC-60206 |
PF-4181366
|
A potent, selective, brain penetrant PDE9A inhibitor with IC50 of 1.8 nM. |
