Cat. No. |
Product Name |
Information |
PC-21623 |
ZCAN262
GluA2 modualtor
|
ZCAN262 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=8.5 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2). |
PC-21030 |
(S)-(-)-DQP-997-74
GluN2C/2D NAM
|
(S)-(-)-DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 69 and 35 nM, respectively, exhibits >100- and >300-fold over GluN2A- and GluN2B-containing receptors. |
PC-20949 |
IEM1460
AMPAR inhibitor
|
IEM-1460 is a selective GluA2-lacking AMPAR inhibitor, blocks Ca2+ permeable AMPA receptors (AMPARs). |
PC-20370 |
GNE-5729
GluN2A PAM
|
GNE-5729 (GNE5729) is a potent, brain penetrant GluN2A-selective NMDAR positive allosteric modulator with EC50 of 37 nM. |
PC-20369 |
GNE-0723
GluN2A PAM
|
GNE-0723 (GNE0723) is a potent, brain penetrant GluN2A-selective NMDAR positive allosteric modulator with EC50 of 21 nM. |
PC-20368 |
GluN2A PAM (R)-9
GluN2A PAM
|
GluN2A PAM (R)-9 is a potent, brain penetrant, GluN2A-selective positive allosteric modulator with EC50 of 0.51 uM, Emax 350%. |
PC-20320 |
JNJ-61432059
AMPAR modulator
|
JNJ-61432059 is a potent, TARPγ-8 selective AMPAR negative modulator with pIC50 of 9.7 in FLIPR assay using HEK-293 cells expressing human GluA1o-γ-8. |
PC-49068 |
UBP684
NMDAR PAM
|
UBP684 is a positive allosteric modulator of N-methyl-D-aspartate receptor (NMDAR), potentiates GluN2A-D NMDAR responses evoked by low agonist concentrations L-glutamate and glycine with EC50 values of 30 uM, and a maximal potentiation of 69 to 117%. |
PC-49067 |
UBP792
NMDAR NAM
|
UBP792 is a novel negative allosteric modulator (antagonist) of NMDA receptors, displays partial subtype-selectivity by having a varied maximal inhibition of GluN2A-, GluN2B-, GluN2C-, and GluN2D-containing receptors (52%, 70%, 87%, 89%, respectively) with IC50 values of 4-10 uM. |
PC-49066 |
GNE-9278
NMDAR PAM
|
GNE-9278 is a potent NMDAR positive allosteric modulator (PAM) that acts at the GluN1 transmembrane domain (TMD), robustly potentiates GluN2A, 2B, 2C and 2D-containing NMDARs in calcium influx assays from HEK cell lines with EC50 values of 0.74, 3.07, 0.47, and 0.32 μM, respectively, and maximum fold potentiation of 5.5, 8.4, 10.2 and 7.9, respectively. |
PC-49065 |
PTC-174
GluN2C/2D PAM
|
PTC-174 is a selective, positive allosteric modulator of NMDA receptors containing GluN2C or GluN2D subunits with EC50 of 4.1 uM (GluN1/2C) and 5.7 uM (GluN1/2D). |
PC-49064 |
PYD-106
GluN2C PAM
|
PYD-106 is a GluN2C-selective NMDA receptor positive allosteric modulator, enhances the maximal current response of GluN1/GluN2C receptors. |