| Cat. No. |
Product Name |
Information |
| PC-61707 |
Becampanel
AMPAR antagonist
|
Becampanel (AMP 397) potent, competitive antagonist of the AMPA receptor (AMPAR) with IC50 of 11 nM. |
| PC-61706 |
Cyclothiazide
AMPAR PAM
|
Cyclothiazide (Doburil) is a positive allosteric modulator of the AMPA and kainate receptors that potentiates AMPA-mediated glutamate currents. |
| PC-61705 |
PF-04701475
AMPAR PAM
|
PF-04701475 is a potent positive allosteric modulator of AMPA receptor with EC50 of 123 nM, a prototype used to explore AMPAR-mediated pharmacology in vivo. |
| PC-61704 |
CX614
AMPAR PAM
|
CX614 is a positive allosteric modulator of AMPA receptors, shows neuroprotective effects for treatment of Parkinson's disease and Alzheimer's disease. |
| PC-61703 |
S-18986
AMPAR PAM
|
S-18986 is an orally bioavailable and BBB penetrant positive allosteric modulator of AMPA receptors. |
| PC-61514 |
Traxoprodil
GluN2B antagonist
|
Traxoprodil (CP101606) is a potent, selective N-methyl-D-aspartate (NMDA) antagonist with selectivity for the NR2B subunit, potently protects cultured hippocampal neurons from glutamate toxicity (IC50=10 nM). |
| PC-61501 |
NS-1209
AMPA antagonist
|
NS-1209 is a selective, water-soluble, in vivo long-lasting AMPA antagonist with Ki of 43 nM. |
| PC-61239 |
(S)93-31
GluN2B antagonist
|
(S)93-31 is a pH-dependent, GluN2B-selective inhibitor of NMDA receptor with IC50 of 0.19 uM at pH6.9, 10-fold selecivity over brain tissue pH 7.6 (IC50=1.8 uM). |
| PC-60899 |
LY 3130481
AMPAR antagonist
|
LY3130481 (CERC611) is a potent, selective, noncompetitive TARP γ8-associated AMPA receptors with IC50 of 65.3 nM (GluA1/TARP γ-8), with no activity for γ-2 (cerebellum) or other TARP members. |
| PC-60783 |
AICP
GluN2C agonist
|
AICP is a potent, selective GluN2C-selective NMDA receptor glycine site superagonist with EC50 of 1.7 nM at GluN1/2C. |
| PC-60772 |
UBP 296
|
UBP 296 (UBP296, UBP-296) is a potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 1.09 uM. |
| PC-60771 |
UBP 302
iGluR antagonist
|
UBP 302 (UBP-302) is a potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 402 nM. |
