| Cat. No. |
Product Name |
Information |
| PC-42745 |
LY450108
AMPAR PAM
|
LY450108 is a potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors. |
| PC-42744 |
LY451395
AMPAR PAM
|
Mibampator (LY451395) is a potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors. |
| PC-42691 |
Rislenemdaz
GluN2B antagonist
|
Rislenemdaz (MK-0657, CERC-301) is a potent, orally bioavailable brain‐penetrant, NR2B-selective NMDA receptor (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM respectively, with no off-target activity. |
| PC-45532 |
L-701324
NMDAR antagonist
|
L-701324 (L-701,324) is a potent, orally active antagonist at the glycine modulatory site on NMDA receptor with IC50 of 2 nM. |
| PC-42742 |
Aniracetam
AMPAR PAM
|
Aniracetam (Ro 13-5057) is a positive allosteric modulator of AMPAR, potentiates the iQA responses induced in Xenopus oocytes by rat brain mRNA in a reversible manner. |
| PC-42743 |
Ampalex
AMPAR PAM
|
Ampalex (CX516) is a positive allosteric modulator of AMPA, increases fast, excitatory (glutamatergic) synaptic responses in hippocampal slices by about 50% with an EC50 of 170 uM. |
| PC-42746 |
Farampator
AMPAR PAM
|
Farampator (CX-691, Org24448) is a positive allosteric modulator of AMPAR as ampakine agent. |
| PC-45344 |
Sunifiram
AMPAR agonist
|
Sunifiram (DM-253) is a piperazine derived ampakine-like agent, is an agonist of AMPA receptor with oral activity, exhibits potent cognitive enhancement effects with better nootropic activity compared to piracetam. |
| PC-23363 |
Lanicemine dihydrochloride
NMDAR antagonist
|
Lanicemine dihydrochloride (AZD6765, ARL-15896) is a low-trapping NMDA channel blocker with Ki of 0.56-2.1 μM, IC50 of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, shows antidepressant effects. |
| PC-23362 |
Lanicemine
NMDAR antagonist
|
Lanicemine (AZD6765, ARL-15896) is a low-trapping NMDA channel blocker with Ki of 0.56-2.1 μM, IC50 of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, shows antidepressant effects. |
| PC-23361 |
MPX-004
GluN2A antagonist
|
MPX-004 is a potent, GluN2A-selective negative allosteric modulator and NMDA antagonist with IC50 of 78 nM for inhibition of Ca2+ responses mediated by GluN2A receptors expressed in HEK cells. |
| PC-23317 |
MDL-29951
GPR17 agonist, NMDAR antagonist
|
MDL-29951 (MDL-29, 951) is a potent glycine antagonist of NMDA receptor with Ki of 0.14 uM for [3H]glycine binding in vitro, also is a potent GPR17 agonist with pEC50 of 6.48. |
