| Cat. No. |
Product Name |
Information |
| PC-61703 |
S-18986
AMPAR PAM
|
S-18986 is an orally bioavailable and BBB penetrant positive allosteric modulator of AMPA receptors. |
| PC-61501 |
NS-1209
AMPA antagonist
|
NS-1209 is a selective, water-soluble, in vivo long-lasting AMPA antagonist with Ki of 43 nM. |
| PC-60899 |
LY 3130481
AMPAR antagonist
|
LY3130481 (CERC611) is a potent, selective, noncompetitive TARP γ8-associated AMPA receptors with IC50 of 65.3 nM (GluA1/TARP γ-8), with no activity for γ-2 (cerebellum) or other TARP members. |
| PC-60772 |
UBP 296
|
UBP 296 (UBP296, UBP-296) is a potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 1.09 uM. |
| PC-45528 |
SYM2206
AMPAR antagonist
|
SYM2206 is an allosteric, non-competitive antagonist of the AMPA receptor with IC50 of 2.8 uM. |
| PC-42691 |
Rislenemdaz
GluN2B antagonist
|
Rislenemdaz (MK-0657, CERC-301) is a potent, orally bioavailable brain‐penetrant, NR2B-selective NMDA receptor (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM respectively, with no off-target activity. |
| PC-42746 |
Farampator
AMPAR PAM
|
Farampator (CX-691, Org24448) is a positive allosteric modulator of AMPAR as ampakine agent. |
| PC-22455 |
FS2921
GluN1/GluN2A NMDAR PAM
|
FS2921 is a potential, functionally selective GluN1/GluN2A positive allosteric modulator (PAM), selective versus GluN1/GluN2B and GluN1/GluN2D, increases NMDAR-mediated currents with EC50 of 8.8 uM. |
| PC-22454 |
GNE-6901
GluN2A PAM
|
GNE-6901 is a selective GluN2A containing NMDAR positive allosteric modulator (PAM) wIth EC50 of 382 nM, binds to the GluN1/GluN2A LBD dimer interface. |
| PC-22453 |
GNE-8324
GluN2A PAM
|
GNE-8324 is a selective GluN2A containing NMDAR positive allosteric modulator (PAM), binds to the GluN1/GluN2A LBD dimer interface. |
| PC-22452 |
Apimostinel
NMDAR agonist
|
Apimostinel (NRX-1074; AGN-241660) is a potential, orally active antidepressant and NMDAR partial agonist. |
| PC-22451 |
MPX-007
GluN2A antagonist
|
MPX-007 is a selective GluN2A antagonist, inhibits GluN2A-containing NMDA receptors expressed in HEK cells with IC50 of 27 nM. |
