| Cat. No. |
Product Name |
Information |
| PC-21623 |
ZCAN262
GluA2 modualtor
|
ZCAN262 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=8.5 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2). |
| PC-21035 |
EU1794-4
NMDAR modulator
|
EU1794-4 is a negative allosteric modulator of NMDA receptors, inhibits all GluN1/GluN2 combinations with IC50 of 0.28-3.1 uM. |
| PC-21031 |
DQP-997-74
GluN2C/2D NAM
|
DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 0.35 and 0.13 uM, respectively, exhibits >100-fold over GluN2A- and GluN2B-containing receptors. |
| PC-21030 |
(S)-(-)-DQP-997-74
GluN2C/2D NAM
|
(S)-(-)-DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 69 and 35 nM, respectively, exhibits >100- and >300-fold over GluN2A- and GluN2B-containing receptors. |
| PC-20949 |
IEM1460
AMPAR inhibitor
|
IEM-1460 is a selective GluA2-lacking AMPAR inhibitor, blocks Ca2+ permeable AMPA receptors (AMPARs). |
| PC-20695 |
NYX-2925
NMDAR PAM
|
NYX-2925 (NYX2925) is a potent, specific NMDAR positive allosteric-modulator, facilitates [3H] MK-801 binding in all four human NMDAR2 subtypes with EC50 of 55 pM, 28 fM, 11 pM, and 55 pM for hNR2A, 2B, 2C, and 2D receptors, respectively. |
| PC-20370 |
GNE-5729
GluN2A PAM
|
GNE-5729 (GNE5729) is a potent, brain penetrant GluN2A-selective NMDAR positive allosteric modulator with EC50 of 37 nM. |
| PC-20369 |
GNE-0723
GluN2A PAM
|
GNE-0723 (GNE0723) is a potent, brain penetrant GluN2A-selective NMDAR positive allosteric modulator with EC50 of 21 nM. |
| PC-20368 |
GluN2A PAM (R)-9
GluN2A PAM
|
GluN2A PAM (R)-9 is a potent, brain penetrant, GluN2A-selective positive allosteric modulator with EC50 of 0.51 uM, Emax 350%. |
| PC-20320 |
JNJ-61432059
TARPγ-8 AMPAR NAM
|
JNJ-61432059 is a potent, TARPγ-8 selective AMPAR negative modulator with pIC50 of 9.7 in FLIPR assay using HEK-293 cells expressing human GluA1o-γ-8. |
| PC-20090 |
BPAM344
GluK2 PAM
|
BPAM344 (BPAM-344) is a positive allosteric modulator of GluK2 kainate receptor, potentiates glutamate-evoked currents of GluK2a 21-fold at 200 uM (EC50=79 uM). |
| PC-49068 |
UBP684
NMDAR PAM
|
UBP684 is a positive allosteric modulator of N-methyl-D-aspartate receptor (NMDAR), potentiates GluN2A-D NMDAR responses evoked by low agonist concentrations L-glutamate and glycine with EC50 values of 30 uM, and a maximal potentiation of 69 to 117%. |
