| Cat. No. |
Product Name |
Information |
| PC-73198 |
QNZ46
GluN2C/D inhibitor
|
QNZ46 is a noncompetitive antagonist of NMDA receptor, selectively inhibits GluN2C/D-containing receptors with IC50 of 3.2/3.9 uM, repectively. |
| PC-72104 |
NP10679
GluN2B inhibitor
|
NP10679 (NP 10679) is a potent, orally active, NMDA receptor subunit 2B (GluN2B)-selective inhibitor of NMDA receptor with IC50 of 23 nM, with no significant effect on GluN2A/C/D (IC50>100 uM). |
| PC-35601 |
JNJ-55511118
AMPAR modulator
|
JNJ-55511118 (JNJ55511118) is a selective, orally available AMPA receptor containing TARP-γ8 negative modulator with Ki of 26 nM, displays no significant activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2. |
| PC-35565 |
UoS12258
AMPAR PAM
|
UoS12258 (UoS-12258) is a selective, positive allosteric modulator of the AMPA receptor with pEC50 of 5.6. |
| PC-35556 |
PF-4778574
AMPAR PAM
|
PF-4778574 (PF4778574) is a brain penetrant, positive allosteric modulator (potentiator) of AMPA receptor with Ki of 85 nM, increases S-AMPA-evoked responses in rat primary cortical neurons with EC50 of 45-919 nM. |
| PC-35544 |
S44819
|
S44819 (S-44819, Egis-1352 Afizagabar) is a novel potent, competitive, selective antagonist of the α5-GABAAR with Kd of 221 nM, IC50 of 585 nM (α5β2γ2). |
| PC-35167 |
BMS-986163
GluN2B modulator
|
BMS-986163 is a water-soluble phosphate prodrug of BMS-986169, which is a novel GluN2B negative allosteric modulator (Ki=4.0 nM).. |
| PC-35166 |
BMS-986169
GluN2B modulator
|
BMS-986169 is a novel GluN2B negative allosteric modulator, demonstrates high binding affinity for the GluN2B allosteric site (Ki=4.0 nM) and selective inhibition of GluN2B receptor function (IC50=24 nM) in cells. |
| PC-63207 |
NAB-14
GluN2C/2D modulator
|
NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors. |
| PC-43078 |
PEPA
AMPAR PAM
|
PEPA is an allosteric potentiator of AMPA receptors, potentiates glutamate responses by 50-fold in oocytes expressing GluRCflop (EC50=50 uM). |
| PC-43076 |
Naspm trihydrochloride
AMPAR antagonist
|
Naspm is a selective antagonist of Ca2+-permeable AMPA receptors, blocks GluR2-lacking AMPARs, suppresses current responses induced by kainate in type II neurons with IC50 of 0.33 uM. |
| PC-43075 |
Naspm
AMPAR antagonist
|
Naspm is a selective antagonist of Ca2+-permeable AMPA receptors, blocks GluR2-lacking AMPARs, suppresses current responses induced by kainate in type II neurons with IC50 of 0.33 uM. |
