| Cat. No. |
Product Name |
Information |
| PC-22292 |
TAK-653
AMPAR PAM
|
TAK-653 (NBI-1065845, Osavampator) is a potent, selective AMPA receptor positive allosteric modulator/potentiator, induces Ca2+ influx in hGluA1i CHO cells with EC50 of 2.2 uM. |
| PC-22280 |
Ro 25-6981
GluN2B antagonist
|
Ro 25-6981 is a potent and selective antagonist of NMDA receptors containing NR2B (GluN2B) subunit with IC50 of 3 nM for inhibition 3H-MK-801 binding to rat forebrain membranes. |
| PC-22279 |
Ro 25-6981 maleate
NMDA NR2B inhibitor
|
Ro 25-6981 maleate is a potent and selective antagonist of NMDA receptors containing NR2B (GluN2B) subunits with IC50 of 3 nM for inhibition 3H-MK-801 binding to rat forebrain membranes. |
| PC-21854 |
FP802
TwinF interface inhibitor
|
FP802 is a potent neuroprotectant and small molecule inhibitor of TwinF interface, shows selective elimination of eNMDAR-mediated toxicity via disruption of the NMDAR/TRPM4 death signaling complex, while sparing the vital physiological functions of synaptic NMDARs. |
| PC-21853 |
Zelquistinel
NMDAR modulator
|
Zelquistinel (AGN-241751) is an orally active NMDAR allosteric modulator, exhibits antidepressant-like activity via positive modulation of GluN2B containing NMDARs in mPFC excitatory neurons. |
| PC-21624 |
ZCAN155
GluA2 modualtor
|
ZCAN155 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=35 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2), restores neurological function and myelination. |
| PC-21623 |
ZCAN262
GluA2 modualtor
|
ZCAN262 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=8.5 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2). |
| PC-21035 |
EU1794-4
NMDAR modulator
|
EU1794-4 is a negative allosteric modulator of NMDA receptors, inhibits all GluN1/GluN2 combinations with IC50 of 0.28-3.1 uM. |
| PC-21031 |
DQP-997-74
GluN2C/2D NAM
|
DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 0.35 and 0.13 uM, respectively, exhibits >100-fold over GluN2A- and GluN2B-containing receptors. |
| PC-21030 |
(S)-(-)-DQP-997-74
GluN2C/2D NAM
|
(S)-(-)-DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 69 and 35 nM, respectively, exhibits >100- and >300-fold over GluN2A- and GluN2B-containing receptors. |
| PC-20949 |
IEM-1460
GluR2-lacking AMPAR antagonist
|
IEM-1460 is a selective GluA2-lacking AMPAR inhibitor / antagonist with KD of 3.0 uM (−80 mV), has >200-fold selectivity over GluR2-containing AMPAR, blocks Ca2+ permeable AMPA receptors (AMPARs). |
| PC-20695 |
NYX-2925
NMDAR PAM
|
NYX-2925 (NYX2925) is a potent, specific NMDAR positive allosteric-modulator, facilitates [3H] MK-801 binding in all four human NMDAR2 subtypes with EC50 of 55 pM, 28 fM, 11 pM, and 55 pM for hNR2A, 2B, 2C, and 2D receptors, respectively. |
