| Cat. No. |
Product Name |
Information |
| PC-23317 |
MDL-29951
GPR17 agonist, NMDAR antagonist
|
MDL-29951 (MDL-29, 951) is a potent glycine antagonist of NMDA receptor with Ki of 0.14 uM for [3H]glycine binding in vitro, also is a potent GPR17 agonist with pEC50 of 6.48. |
| PC-23269 |
EU1622-240
NMDAR PAM
|
EU1622-240 is a positive allosteric modulator of NMDA receptors (NMDARs), preferentially potentiate GluN2B-, GluN2C-, and GluN2D-containing NMDARs with EC50 of 0.57 uM, 0.82 uM and 1.1 uM respectively. |
| PC-23082 |
Risevistinel
NMDAR PAM
|
Risevistinel (NYX-783, NYX783) is a potent, specific N-methyl-D-aspartate receptor (NMDAR) positive allosteric-modulator. |
| PC-22452 |
Apimostinel
NMDAR agonist
|
Apimostinel (NRX-1074; AGN-241660) is a potential, orally active antidepressant and NMDAR partial agonist. |
| PC-22450 |
TCN201
GluN2A antagonist
|
TCN201 (TCN-201) is a selective GluN2A-containing NMDARs antagonist with pIC50 of 6.8 uM for GluN1/GluN2A NMDAR, negligible effect on GluN1/GluN2B NMDA receptor. |
| PC-22292 |
TAK-653
AMPAR PAM
|
TAK-653 (NBI-1065845, Osavampator) is a potent, selective AMPA receptor positive allosteric modulator/potentiator, induces Ca2+ influx in hGluA1i CHO cells with EC50 of 2.2 uM. |
| PC-22280 |
Ro 25-6981
GluN2B antagonist
|
Ro 25-6981 is a potent and selective antagonist of NMDA receptors containing NR2B (GluN2B) subunit with IC50 of 3 nM for inhibition 3H-MK-801 binding to rat forebrain membranes. |
| PC-22279 |
Ro 25-6981 maleate
NMDA NR2B inhibitor
|
Ro 25-6981 maleate is a potent and selective antagonist of NMDA receptors containing NR2B (GluN2B) subunits with IC50 of 3 nM for inhibition 3H-MK-801 binding to rat forebrain membranes. |
| PC-21854 |
FP802
TwinF interface inhibitor
|
FP802 is a potent neuroprotectant and small molecule inhibitor of TwinF interface, shows selective elimination of eNMDAR-mediated toxicity via disruption of the NMDAR/TRPM4 death signaling complex, while sparing the vital physiological functions of synaptic NMDARs. |
| PC-21853 |
Zelquistinel
NMDAR modulator
|
Zelquistinel (AGN-241751) is an orally active NMDAR allosteric modulator, exhibits antidepressant-like activity via positive modulation of GluN2B containing NMDARs in mPFC excitatory neurons. |
| PC-21624 |
ZCAN155
GluA2 modualtor
|
ZCAN155 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=35 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2), restores neurological function and myelination. |
| PC-21623 |
ZCAN262
GluA2 modualtor
|
ZCAN262 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=8.5 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2). |
