| Cat. No. |
Product Name |
Information |
| PC-49067 |
UBP792
NMDAR NAM
|
UBP792 is a novel negative allosteric modulator (antagonist) of NMDA receptors, displays partial subtype-selectivity by having a varied maximal inhibition of GluN2A-, GluN2B-, GluN2C-, and GluN2D-containing receptors (52%, 70%, 87%, 89%, respectively) with IC50 values of 4-10 uM. |
| PC-49066 |
GNE-9278
NMDAR PAM
|
GNE-9278 is a potent NMDAR positive allosteric modulator (PAM) that acts at the GluN1 transmembrane domain (TMD), robustly potentiates GluN2A, 2B, 2C and 2D-containing NMDARs in calcium influx assays from HEK cell lines with EC50 values of 0.74, 3.07, 0.47, and 0.32 μM, respectively, and maximum fold potentiation of 5.5, 8.4, 10.2 and 7.9, respectively. |
| PC-49065 |
PTC-174
GluN2C/2D PAM
|
PTC-174 is a selective, positive allosteric modulator of NMDA receptors containing GluN2C or GluN2D subunits with EC50 of 4.1 uM (GluN1/2C) and 5.7 uM (GluN1/2D). |
| PC-49064 |
PYD-106
GluN2C PAM
|
PYD-106 is a GluN2C-selective NMDA receptor positive allosteric modulator, enhances the maximal current response of GluN1/GluN2C receptors. |
| PC-49063 |
SAGE-718
NMDAR PAM
|
Dalzanemdor (SAGE-718) is a potent and high intrinsic activity N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulator with EC50 of 86 and 79 nM for GluN2A and GluN2B, respectively, reverses DOI-induced increases in locomotor activity. |
| PC-38728 |
WMS-1410
NR2B receptor antagonist
|
WMS-1410 is a NR2B selective NMDA receptor antagonist with Ki value of 14 nM, antagonizes glutamate induced excitotoxicity with IC50 of 18.4 nM. |
| PC-38673 |
Plazinemdor
NMDA PAM
|
Plazinemdor (CAD-9303) is a potent N-methyl-D-aspartate (NMDA) receptor positive allosteric modulator with potential for schizophrenia. |
| PC-73437 |
Posovolone
GABAA PAM
|
Posovolone (Co134444) is a GABAA receptor positive allosteric modulator with antidepressant activity. |
| PC-73433 |
Onfasprodil
NMDA NR2B inhibitor
|
Onfasprodil (MIJ-821, MIJ821) is a potent, selective negative allosteric modulator of NR2B N-Methyl D-Aspartate receptor receptor (NR2B NMDA receptor), with a potentially low rate of the psychotomimetic side effects. |
| PC-73198 |
QNZ46
GluN2C/D inhibitor
|
QNZ46 is a noncompetitive antagonist of NMDA receptor, selectively inhibits GluN2C/D-containing receptors with IC50 of 3.2/3.9 uM, repectively. |
| PC-72104 |
NP10679
GluN2B inhibitor
|
NP10679 (NP 10679) is a potent, orally active, NMDA receptor subunit 2B (GluN2B)-selective inhibitor of NMDA receptor with IC50 of 23 nM, with no significant effect on GluN2A/C/D (IC50>100 uM). |
| PC-38029 |
D-AP5
NMDAR antagonist
|
D-AP5 is a selective NMDA receptor antagonist that competes with glutamate binding with Kd of 1.4 uM, is commonly used to inhibit NMDA-dependent synaptic plasticity. |
