| Cat. No. |
Product Name |
Information |
| PC-21029 |
DQP-1105
GluN2C/2D antagonist
|
DQP-1105 is a selective GluN2C- and GluN2D-containing NMDARs antagonist with IC50 of 7.0 and 2.7 uM respectively, >50-fold selectivity over GluN2A- or GluN2B-containing receptors. |
| PC-20695 |
NYX-2925
NMDAR PAM
|
NYX-2925 (NYX2925) is a potent, specific NMDAR positive allosteric-modulator, facilitates [3H] MK-801 binding in all four human NMDAR2 subtypes with EC50 of 55 pM, 28 fM, 11 pM, and 55 pM for hNR2A, 2B, 2C, and 2D receptors, respectively. |
| PC-20370 |
GNE-5729
GluN2A PAM
|
GNE-5729 (GNE5729) is a potent, brain penetrant GluN2A-selective NMDAR positive allosteric modulator with EC50 of 37 nM. |
| PC-20369 |
GNE-0723
GluN2A PAM
|
GNE-0723 (GNE0723) is a potent, brain penetrant GluN2A-selective NMDAR positive allosteric modulator with EC50 of 21 nM. |
| PC-20368 |
GluN2A PAM (R)-9
|
GluN2A PAM (R)-9 is a potent, brain penetrant, GluN2A-selective positive allosteric modulator with EC50 of 0.51 uM, Emax 350%. |
| PC-20320 |
JNJ-61432059
AMPAR/γ-8 inhibitor
|
JNJ-61432059 is a potent, TARPγ-8 selective AMPAR negative modulator with pIC50 of 9.7 in FLIPR assay using HEK-293 cells expressing human GluA1o-γ-8. |
| PC-20090 |
BPAM344
GluK2 PAM
|
BPAM344 (BPAM-344) is a positive allosteric modulator of GluK2 kainate receptor, potentiates glutamate-evoked currents of GluK2a 21-fold at 200 uM (EC50=79 uM). |
| PC-38728 |
WMS-1410
NR2B receptor antagonist
|
WMS-1410 is a NR2B selective NMDA receptor antagonist with Ki value of 14 nM, antagonizes glutamate induced excitotoxicity with IC50 of 18.4 nM. |
| PC-38673 |
Plazinemdor
NMDA PAM
|
Plazinemdor (CAD-9303) is a potent N-methyl-D-aspartate (NMDA) receptor positive allosteric modulator with potential for schizophrenia. |
| PC-73437 |
Posovolone
GABAA PAM
|
Posovolone is a GABAA receptor positive allosteric modulator with antidepressant activity. |
| PC-73433 |
Onfasprodil
NMDA antagonist
|
Onfasprodil is a potent, selective N-methyl-D-aspartate (NMDA) receptor antagonist. |
| PC-38029 |
D-AP5
|
D-AP5 is a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. |
