| Cat. No. |
Product Name |
Information |
| PC-42742 |
Aniracetam
AMPAR PAM
|
Aniracetam (Ro 13-5057) is a positive allosteric modulator of AMPAR, potentiates the iQA responses induced in Xenopus oocytes by rat brain mRNA in a reversible manner. |
| PC-42743 |
Ampalex
AMPAR PAM
|
Ampalex (CX516) is a positive allosteric modulator of AMPA, increases fast, excitatory (glutamatergic) synaptic responses in hippocampal slices by about 50% with an EC50 of 170 uM. |
| PC-42746 |
Farampator
AMPAR PAM
|
Farampator (CX-691, Org24448) is a positive allosteric modulator of AMPAR as ampakine agent. |
| PC-45344 |
Sunifiram
AMPAR agonist
|
Sunifiram (DM-253) is a piperazine derived ampakine-like agent, is an agonist of AMPA receptor with oral activity, exhibits potent cognitive enhancement effects with better nootropic activity compared to piracetam. |
| PC-25676 |
Fanapanel
AMPA antagonist
|
Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonis with Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. |
| PC-25186 |
GluN2A PAM Y36
GluN2A PAM
|
GluN2A PAM Y36 is a potent, GluN2A-selective N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulator with EC50 of 24.97 uM, Emax=397.7%. |
| PC-25185 |
GNE-3419
GluN2A PAM
|
GNE-3419 is a potent, GluN2A-selective NMDA receptor (NMDAR) positive allosteric modulator with EC50 of 1.9 uM, Emax=150%, 10-fold lower with GluN2D. |
| PC-25090 |
Satoprodil
NMDAR NAM
|
Satoprodil is a potent, selective negative allosteric modulator NMDA receptor NR2B subunit. |
| PC-24115 |
Blixeprodil
NMDAR antagonist
|
Blixeprodil (GM-1020) is a selective NMDA receptor (NMDAR) antagonist, displaces [3H]MK-801 binding to NMDAR in rat cortical tissue with Ki of 3.25 uM. |
| PC-23906 |
HZS60
NMDAR/TRPM4 inhibitor
|
HZS60 is a specific NMDAR/TRPM4 interaction interface inhibitor, displays significant neuroprotective effects against both NMDA and oxygen-glucose deprivation/reoxygenation-induced ischemic injury in primary neurons. |
| PC-23690 |
SYM2081
GluK2 agonist
|
SYM2081 is a potent, specific agonist of glutamate receptor ionotropic kainate 2 (GluK2) with EC50 of 0.2 uM, inhibits inhibits [3H]-kainate binding with IC50 of 35 nM. |
| PC-23363 |
Lanicemine dihydrochloride
NMDAR antagonist
|
Lanicemine dihydrochloride (AZD6765, ARL-15896) is a low-trapping NMDA channel blocker with Ki of 0.56-2.1 μM, IC50 of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, shows antidepressant effects. |
