| Cat. No. |
Product Name |
Information |
| PC-24489 |
Riluzole
Glutamate modulator, TPC2 agonist
|
Riluzole is an anticonvulsant agent and N-methyl-D-aspartate (NMDA) glutamate receptor blocker, also is a TPC2 activator, also inhibited Kv4.2, Kv4.2/DPP6, and Kv4.2/KChIP2c channels in a voltage-independent manner, also binds to the C-terminal domain of SARS-CoV-2 nucleocapsid protein and has antiviral activity. |
| PC-24115 |
Blixeprodil
NMDAR antagonist
|
Blixeprodil (GM-1020) is a selective NMDA receptor (NMDAR) antagonist, displaces [3H]MK-801 binding to NMDAR in rat cortical tissue with Ki of 3.25 uM. |
| PC-23906 |
HZS60
NMDAR/TRPM4 inhibitor
|
HZS60 is a specific NMDAR/TRPM4 interaction interface inhibitor, displays significant neuroprotective effects against both NMDA and oxygen-glucose deprivation/reoxygenation-induced ischemic injury in primary neurons. |
| PC-23690 |
SYM2081
GluK2 agonist
|
SYM2081 is a potent, specific agonist of glutamate receptor ionotropic kainate 2 (GluK2) with EC50 of 0.2 uM, inhibits inhibits [3H]-kainate binding with IC50 of 35 nM. |
| PC-23363 |
Lanicemine dihydrochloride
NMDAR antagonist
|
Lanicemine dihydrochloride (AZD6765, ARL-15896) is a low-trapping NMDA channel blocker with Ki of 0.56-2.1 μM, IC50 of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, shows antidepressant effects. |
| PC-23362 |
Lanicemine
NMDAR antagonist
|
Lanicemine (AZD6765, ARL-15896) is a low-trapping NMDA channel blocker with Ki of 0.56-2.1 μM, IC50 of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, shows antidepressant effects. |
| PC-23361 |
MPX-004
GluN2A antagonist
|
MPX-004 is a potent, GluN2A-selective negative allosteric modulator and NMDA antagonist with IC50 of 78 nM for inhibition of Ca2+ responses mediated by GluN2A receptors expressed in HEK cells. |
| PC-23317 |
MDL-29951
GPR17 agonist, NMDAR antagonist
|
MDL-29951 (MDL-29, 951) is a potent glycine antagonist of NMDA receptor with Ki of 0.14 uM for [3H]glycine binding in vitro, also is a potent GPR17 agonist with pEC50 of 6.48. |
| PC-23271 |
CX1942
AMPAR modulator
|
CX1763 is an allosteric modulator of AMPA receptor, enhances synaptic transmission in hippocampi of rats. |
| PC-23270 |
CX1763
AMPAR modulator
|
CX1763 is an allosteric modulator of AMPA receptor, enhances synaptic transmission in hippocampi of rats. |
| PC-23086 |
Nevadistinel
NMDAR PAM
|
Nevadistinel (NYX-458, NYX-3054) is a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor. |
| PC-23082 |
Risevistinel
NMDAR PAM
|
Risevistinel (NYX-783, NYX783) is a potent, specific NMDAR positive allosteric-modulator. |
