| Cat. No. |
Product Name |
Information |
| PC-27330 |
GluN2A NAM 6a
GluN2A inhibitor
|
GluN2A NAM 6a is a potent, selective nonsulfonamide GluN2A negative allosteric modulator / inhibitor with IC50 of 3.91 uM, with no activity against GluN2B/C/D. |
| PC-27283 |
CX717
AMPAR PAM
|
CX717 is a positive allosteric modulator of AMPA receptors, prevents opiate-induced respiratory depression, shows antidepressant activities. |
| PC-26935 |
Memantine
NMDA receptor antagonist
|
Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist with Ki of 0.19 uM for competing with [3H]MK-801 binding in membrane homogenates of postmortem human frontal cortex. |
| PC-26837 |
Fluoroethylnormemantine
NMDA receptor antagonist
|
Fluoroethylnormemantine (FENM) is a structural analogue of Memantine and NMDA receptor antagonist with Ki of 3.5 uM, exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects. |
| PC-26348 |
Otefprodil
GluN2B antagonist
|
Otefprodil is a potent, selective antagonist of NR2B (GluN2B)-containing NMDA receptors, inhibits glutamic acid and glycine induced activation. |
| PC-26281 |
CGP-78608 hydrochloride
GluN1 antagonist
|
CGP 78608 hydrochloride is a highly potent and selective antagonist of GluN1/GluN3 NMDAR, antagonizes GluN1/GluN2 receptors, acts as an ultra-potent and powerful potentiator of GluN1/GluN3A receptors. |
| PC-26278 |
EU1180-438
GluN1/GluN3 receptor antagonist
|
EU1180-438 is potent, selective GluN1/GluN3 receptor negative allosteric modulator (NAM) / antagonist with IC50 of 3.5 uM, highly selective over GluN1/GluN2 NMDA receptors, AMPA, and kainate receptors. |
| PC-26197 |
GluN2B antagonist 22
GluN2B antagonist
|
GluN2B antagonist 22 (MK-22) is a highly potent, GluN2B (NR2B)-selective NMDA receptor antagonist with IC50/Ki of 1.0 nM and 0.88 nM, respectively. |
| PC-26195 |
R-(+)-EU-1180-453
GluN2C/D PAM
|
R-(+)-EU-1180-453 is a potent, second-generation GluN2C/D-selective NMDAR-positive allosteric modulator (PAM), with no effect on GluN1/GluN2A and GluN1/GluN2B. |
| PC-26194 |
EU93-31
GluN2B antagonist
|
EU93-31 is a potent, pH-sensitive GluN2B-selective antagonist of NMDA receptor with IC50 of 0.19 uM (GluN1/GluN2B, pH=6.9) and 1.8 uM (GluN1/GluN2B, pH=7.6). |
| PC-26193 |
EU93-108
GluN2B NAM
|
EU93-108 is a potent, brain penetrant GluN2B-selective negative allosteric modulator (NAM) of NMDA receptor with IC50 of 0.557 uM (GluN1/GluN2B), with limited activity against GluN1/GluN2A, GluN1/GluN2C and GluN1/GluN2D |
| PC-26192 |
UCM-101
GluN2A NAM
|
UCM-101 is a potent, selective negative allosteric modulator of GluN2A-containing NMDA receptors with IC50 of 0.11 uM for GluN1/2A, 17-, 35-, and 118-fold selective for GluN1/2A over GluN1/2B, GluN1/2C, and GluN1/2D receptors, respectively. |
