| Cat. No. |
Product Name |
Information |
| PC-25808 |
Radiprodil
GluN2B antagonist
|
Radiprodil (RGH-896) is a selective, negative allosteric modulator / antagonist of GluN2B-containing NMDA receptors (GluN2B) with IC50 of 3-10 nM, with no activity against NR2A receptors. |
| PC-25676 |
Fanapanel
AMPA antagonist
|
Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonis with Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. |
| PC-25186 |
GluN2A PAM Y36
GluN2A PAM
|
GluN2A PAM Y36 is a potent, GluN2A-selective N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulator with EC50 of 24.97 uM, Emax=397.7%. |
| PC-25185 |
GNE-3419
GluN2A PAM
|
GNE-3419 is a potent, GluN2A-selective NMDA receptor (NMDAR) positive allosteric modulator with EC50 of 1.9 uM, Emax=150%, 10-fold lower with GluN2D. |
| PC-25090 |
Satoprodil
NMDAR NAM
|
Satoprodil is a potent, selective negative allosteric modulator NMDA receptor NR2B subunit. |
| PC-24115 |
Blixeprodil
NMDAR antagonist
|
Blixeprodil (GM-1020) is a selective NMDA receptor (NMDAR) antagonist, displaces [3H]MK-801 binding to NMDAR in rat cortical tissue with Ki of 3.25 uM. |
| PC-23906 |
HZS60
NMDAR/TRPM4 inhibitor
|
HZS60 is a specific NMDAR/TRPM4 interaction interface inhibitor, displays significant neuroprotective effects against both NMDA and oxygen-glucose deprivation/reoxygenation-induced ischemic injury in primary neurons. |
| PC-23690 |
SYM2081
GluK2 agonist
|
SYM2081 is a potent, specific agonist of glutamate receptor ionotropic kainate 2 (GluK2) with EC50 of 0.2 uM, inhibits inhibits [3H]-kainate binding with IC50 of 35 nM. |
| PC-23363 |
Lanicemine dihydrochloride
NMDAR antagonist
|
Lanicemine dihydrochloride (AZD6765, ARL-15896) is a low-trapping NMDA channel blocker with Ki of 0.56-2.1 μM, IC50 of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, shows antidepressant effects. |
| PC-23362 |
Lanicemine
NMDAR antagonist
|
Lanicemine (AZD6765, ARL-15896) is a low-trapping NMDA channel blocker with Ki of 0.56-2.1 μM, IC50 of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, shows antidepressant effects. |
| PC-23271 |
CX1942
AMPAR modulator
|
CX1763 is an allosteric modulator of AMPA receptor, enhances synaptic transmission in hippocampi of rats. |
| PC-23270 |
CX1763
AMPAR modulator
|
CX1763 is an allosteric modulator of AMPA receptor, enhances synaptic transmission in hippocampi of rats. |
