| Cat. No. |
Product Name |
Information |
| PC-35601 |
JNJ-55511118
AMPAR modulator
|
JNJ-55511118 (JNJ55511118) is a selective, orally available AMPA receptor containing TARP-γ8 negative modulator with Ki of 26 nM, displays no significant activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2. |
| PC-35565 |
UoS12258
AMPAR PAM
|
UoS12258 (UoS-12258) is a selective, positive allosteric modulator of the AMPA receptor with pEC50 of 5.6. |
| PC-35556 |
PF-4778574
AMPAR PAM
|
PF-4778574 (PF4778574) is a brain penetrant, positive allosteric modulator (potentiator) of AMPA receptor with Ki of 85 nM, increases S-AMPA-evoked responses in rat primary cortical neurons with EC50 of 45-919 nM. |
| PC-35544 |
S44819
α5-GABAAR antagonist
|
S44819 (S-44819, Egis-1352 Afizagabar) is a novel potent, competitive, selective antagonist of the α5-GABAAR with Kd of 221 nM, IC50 of 585 nM (α5β2γ2). |
| PC-35167 |
BMS-986163
GluN2B modulator
|
BMS-986163 is a water-soluble phosphate prodrug of BMS-986169, which is a novel GluN2B negative allosteric modulator (Ki=4.0 nM).. |
| PC-35166 |
BMS-986169
GluN2B modulator
|
BMS-986169 is a novel GluN2B negative allosteric modulator, demonstrates high binding affinity for the GluN2B allosteric site (Ki=4.0 nM) and selective inhibition of GluN2B receptor function (IC50=24 nM) in cells. |
| PC-43361 |
SDZ 220-581
NMDAR antagonist
|
SDZ 220-581 is a potent, competitive NMDA receptor antagonist with pKi of 7.7, fully protects against maximal electroshock seizures (MES) at oral doses of 10 mg/kg in rats and in mice. |
| PC-43280 |
Ifenprodil tartrate
GluN2B antagonist
|
Ifenprodil tartrate is a potent, GluN2B-specific inhibitor NMDA receptor antagonist, specifically targets NR1A/NR2B receptors with IC50 of 0.34 uM, 400-fold selective over NR1A/NR2A receptors. |
| PC-43279 |
Eliprodil
GluN2B antagonist
|
Eliprodil (SL-820715) is a non-competitive NR2B-NMDA receptor (GluN2B) antagonist with IC50 of 1 uM, less potent for NR2A- and NR2C-containing receptors (IC50>100 uM). |
| PC-63207 |
NAB-14
GluN2C/2D modulator
|
NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors. |
| PC-43078 |
PEPA
AMPAR PAM
|
PEPA is an allosteric potentiator of AMPA receptors, potentiates glutamate responses by 50-fold in oocytes expressing GluRCflop (EC50=50 uM). |
| PC-43077 |
CMPDA
GluR2 PAM
|
CMPDA is a potent positive allosteric modulator of GluR2 receptors with EC50 of 45.4 and 63.4 nM at GluR2i and GluR2o respectively, in a calcium influx screening assays. |
