| Cat. No. |
Product Name |
Information |
| PC-21854 |
FP802
NMDAR/TRPM4 inhibitor
|
FP802 is a potent neuroprotectant and small molecule inhibitor of TwinF interface, shows selective elimination of eNMDAR-mediated toxicity via disruption of the NMDAR/TRPM4 death signaling complex, while sparing the vital physiological functions of synaptic NMDARs. |
| PC-21853 |
Zelquistinel
NMDAR modulator
|
Zelquistinel (AGN-241751) is an orally active NMDAR allosteric modulator, exhibits antidepressant-like activity via positive modulation of GluN2B containing NMDARs in mPFC excitatory neurons. |
| PC-21624 |
ZCAN155
GluA2 modualtor
|
ZCAN155 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=35 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2), restores neurological function and myelination. |
| PC-21623 |
ZCAN262
GluA2 modualtor
|
ZCAN262 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=8.5 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2). |
| PC-21397 |
(R)-OF-NB1
NMDAR antagonist
|
(R)-OF-NB1 is a small molecule splice variant GluN2B-selective NMDAR antagonist with IC50 of 675 nM and 97 nM for F-NB1 for splice variant containing exon 5 and GluN1-1a in X. laevis oocytes. |
| PC-21036 |
GluN2B NAM 12
GluN2B NAM
|
GluN2B NAM 12 (GluN2B negative allosteric modulator 12) is a selective negative allosteric modulator of GluN2B NMDAR with IC50 of 31 nM and Ki of 15 nM (hGluN2B). |
| PC-21035 |
EU1794-4
NMDAR modulator
|
EU1794-4 is a negative allosteric modulator of NMDA receptors, inhibits all GluN1/GluN2 combinations with IC50 of 0.28-3.1 uM. |
| PC-21034 |
UBP141
GluN2C/2D antagonist
|
UBP141 is a selective GluN2C/2D-containing NMDA receptors antagonist with Kd values of 2.8 and 4.2 uM respecitvely, shows weaker activities against GluN2A and 2B (Kd=14.2 and 19.3 uM). |
| PC-21033 |
UBP791
GluN2C/2D antagonist
|
UBP791 is a subtype-selective competitive antagonist of GluN2C/2D-containing NMDA receptors with Ki of 80-90 nM, 50-fold selectivity over GluN2A and GluN2B. |
| PC-21032 |
UBP1700
GluN2C/2D antagonist
|
UBP1700 is a subtype-selective competitive antagonist of GluN2C/2D-containing NMDA receptors with Ki of 7-9 nM, 50-fold selectivity over GluN2A and GluN2B. |
| PC-21031 |
DQP-997-74
GluN2C/2D NAM
|
DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 0.35 and 0.13 uM, respectively, exhibits >100-fold over GluN2A- and GluN2B-containing receptors. |
| PC-21030 |
(S)-(-)-DQP-997-74
GluN2C/2D NAM
|
(S)-(-)-DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 69 and 35 nM, respectively, exhibits >100- and >300-fold over GluN2A- and GluN2B-containing receptors. |
