| Cat. No. |
Product Name |
Information |
| PC-28147 |
gamma-Glu-Gly
NMDA GluN1/mGlu5 agonist
|
γ-Glutamyl-Glycine (γ-Glu-Gly) is a a glutathione metabolite and seletive partial agonist of NMDA GluN1 and mGlu5 receptors, with no bindding for glutamate binding domain on both AMPA and NMDA GluN2A receptors, triggers a long-term increase in synaptic transmission in the CA1 area of mouse hippocampus. |
| PC-27687 |
GluN2B-NMDAR antagonist-1
GluN2B antagonist
|
GluN2B-NMDAR antagonist-1 (Compound Z25) is a selective GluN2B subunit-containing NMDA receptor antagonist, inhibits Ca2+ influx induced by NMDA. |
| PC-26280 |
EU1180-560
GluN1/GluN3A antagonist
|
EU1180-560 is a subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor with IC50 of 2.6 uM, with no detectable effect on GluN1/GluN3B receptors. |
| PC-26279 |
EU1180-590
GluN1/GluN3A antagonist
|
EU1180-590 is a brain penetrant, subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor with IC50 of 3.7 uM, with no detectable effect on GluN1/GluN3B receptors. |
| PC-26196 |
EVT-101
GluN2B antagonist
|
EVT-101 is a highly potent, selective and orally active GluN2B antagonist with IC50 of 12 nM for GluN1/GluN2B. |
| PC-25963 |
FP802 hydrochloride
TwinF interface inhibitor
|
FP802 hydrochloride is a potent neuroprotectant and small molecule inhibitor of TwinF interface, shows selective elimination of eNMDAR-mediated toxicity via disruption of the NMDAR/TRPM4 death signaling complex, while sparing the vital physiological functions of synaptic NMDARs. |
| PC-25186 |
GluN2A PAM Y36
GluN2A PAM
|
GluN2A PAM Y36 is a potent, GluN2A-selective N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulator with EC50 of 24.97 uM, Emax=397.7%. |
| PC-25090 |
Satoprodil
GluN2B NAM
|
Satoprodil (BI 1569912) is a potent, oral, selective negative allosteric modulator (NAM) of GluN2B subunit-containing NMDA receptors. |
| PC-24631 |
JNJ-78911118
GluN2A antagonist
|
JNJ-78911118 is a potent, centrally-penetrant, selective antagonist of GluN2A-containing NMDA receptors, blocks GluN1/2AR-induced calcium flux with IC50 of 46 nM. |
| PC-24489 |
Riluzole
Glutamate modulator, TPC2 agonist
|
Riluzole is an anticonvulsant agent and N-methyl-D-aspartate (NMDA) glutamate receptor blocker, also is a TPC2 activator, also inhibits Kv4.2, Kv4.2/DPP6, and Kv4.2/KChIP2c channels in a voltage-independent manner. |
| PC-23361 |
MPX-004
GluN2A antagonist
|
MPX-004 is a potent, GluN2A-selective negative allosteric modulator and NMDA antagonist with IC50 of 78 nM for inhibition of Ca2+ responses mediated by GluN2A receptors expressed in HEK cells. |
| PC-23317 |
MDL-29951
GPR17 agonist, NMDAR antagonist
|
MDL-29951 (MDL-29, 951) is a potent glycine antagonist of NMDA receptor with Ki of 0.14 uM for [3H]glycine binding in vitro, also is a potent GPR17 agonist with pEC50 of 6.48. |
