| Cat. No. |
Product Name |
Information |
| PC-23906 |
HZS60
NMDAR/TRPM4 inhibitor
|
HZS60 is a specific NMDAR/TRPM4 interaction interface inhibitor, displays significant neuroprotective effects against both NMDA and oxygen-glucose deprivation/reoxygenation-induced ischemic injury in primary neurons. |
| PC-23690 |
SYM2081
GluK2 agonist
|
SYM2081 is a potent, specific agonist of glutamate receptor ionotropic kainate 2 (GluK2) with EC50 of 0.2 uM, inhibits inhibits [3H]-kainate binding with IC50 of 35 nM. |
| PC-23363 |
Lanicemine dihydrochloride
NMDAR antagonist
|
Lanicemine dihydrochloride (AZD6765, ARL-15896) is a low-trapping NMDA channel blocker with Ki of 0.56-2.1 μM, IC50 of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, shows antidepressant effects. |
| PC-23362 |
Lanicemine
NMDAR antagonist
|
Lanicemine (AZD6765, ARL-15896) is a low-trapping NMDA channel blocker with Ki of 0.56-2.1 μM, IC50 of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, shows antidepressant effects. |
| PC-23271 |
CX1942
AMPAR modulator
|
CX1763 is an allosteric modulator of AMPA receptor, enhances synaptic transmission in hippocampi of rats. |
| PC-23270 |
CX1763
AMPAR modulator
|
CX1763 is an allosteric modulator of AMPA receptor, enhances synaptic transmission in hippocampi of rats. |
| PC-23086 |
Nevadistinel
NMDAR PAM
|
Nevadistinel (NYX-458, NYX-3054) is a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor. |
| PC-22610 |
NS3763
GLUK5 antagonist
|
NS3763 is a noncompetitive antagonist of GLUK5 receptor, inhibits domoate-induced increase in intracellular calcium mediated through the GLU(K5) of kainate receptors with IC50 of 1.6 uM, with no effect on GLU(K6) subtype. |
| PC-22609 |
3-Hydroxykynurenine
iGluR modulator
|
3-Hydroxykynurenine (3-HK) is a metabolite produced through host tryptophan metabolism, restricts bacterial expansion in macrophages via a systemic mechanism, modulates the activity of iGluR receptors of the AMPAR and KAR subclasses. |
| PC-22608 |
Rapastinel trifluoroacetate
NMDAR agonist
|
Rapastinel (GLYX-13, Thr-Pro-Pro-Thr-NH2) trifluoroacetateis a tetrapeptide (TPPT-amide) that acts as a NMDA receptor glycine site partial agonist. |
| PC-22455 |
FS2921
GluN1/GluN2A NMDAR PAM
|
FS2921 is a potential, functionally selective GluN1/GluN2A positive allosteric modulator (PAM), selective versus GluN1/GluN2B and GluN1/GluN2D, increases NMDAR-mediated currents with EC50 of 8.8 uM. |
| PC-22454 |
GNE-6901
GluN2A PAM
|
GNE-6901 is a selective GluN2A containing NMDAR positive allosteric modulator (PAM) wIth EC50 of 382 nM, binds to the GluN1/GluN2A LBD dimer interface. |
