| Cat. No. |
Product Name |
Information |
| PC-42744 |
LY451395
AMPAR PAM
|
Mibampator (LY451395) is a potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors. |
| PC-42691 |
Rislenemdaz
GluN2B antagonist
|
Rislenemdaz (MK-0657, CERC-301) is a potent, orally bioavailable brain-penetrant, NR2B-selective NMDA receptor (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM respectively, with no off-target activity. |
| PC-45532 |
L-701324
NMDAR antagonist
|
L-701324 (L-701,324) is a potent, orally active antagonist at the glycine modulatory site on NMDA receptor with IC50 of 2 nM. |
| PC-42742 |
Aniracetam
AMPAR PAM
|
Aniracetam (Ro 13-5057) is a positive allosteric modulator of AMPAR, potentiates the iQA responses induced in Xenopus oocytes by rat brain mRNA in a reversible manner. |
| PC-42743 |
Ampalex
AMPAR PAM
|
Ampalex (CX516) is a positive allosteric modulator of AMPA, increases fast, excitatory (glutamatergic) synaptic responses in hippocampal slices by about 50% with an EC50 of 170 uM. |
| PC-42746 |
Farampator
AMPAR PAM
|
Farampator (CX-691, Org24448) is a positive allosteric modulator of AMPAR as ampakine agent. |
| PC-45344 |
Sunifiram
AMPAR agonist
|
Sunifiram (DM-253) is a piperazine derived ampakine-like agent, is an agonist of AMPA receptor with oral activity, exhibits potent cognitive enhancement effects with better nootropic activity compared to piracetam. |
| PC-28341 |
Pregnanolone sulfate pyridinium
NMDA receptor inhibitor
|
Pregnanolone sulfate pyridinium (PregS) is an endogenous neurosteroid that inhibits NMDA receptors, acts as a cognitive enhancer and modulator of neurotransmission. |
| PC-27572 |
IEM-1754
GluR2-lacking AMPAR antagonist
|
IEM-1754 is a selective antagonist of GluR2-lacking AMPA receptors (AMPAR) with KD of 12.0 uM (−80 mV), has >80-fold selectivity over GluR2-containing AMPAR. |
| PC-27571 |
IEM-1925
GluR2-lacking AMPAR antagonist
|
IEM-1925 is a selective antagonist of GluR2-lacking AMPA receptors (AMPAR) with KD of 1.1 uM (−80 mV), >100-fold selective over GluR2-containing AMPAR. |
| PC-27552 |
GYKI-53655
AMPAR antagonist
|
GYKI-53655 (GYKI 53655, LY300168) is a non-competitive AMPA receptor antagonist with IC50 of 5.9 uM. |
| PC-27551 |
UBP310
Kainate receptor antagoist
|
UBP310 is a high affinity, selective antagonist of kainate receptor GluR5 with Kd of 130 nM, has >800-fold selecitvity over GluR2 and GluR6, binds to GluK1 with KD of 21 nM, but shows no specific binding to GluK2. |
