| Cat. No. |
Product Name |
Information |
| PC-26278 |
EU1180-438
GluN1/GluN3 receptor antagonist
|
EU1180-438 is potent, selective GluN1/GluN3 receptor negative allosteric modulator (NAM) / antagonist with IC50 of 3.5 uM, highly selective over GluN1/GluN2 NMDA receptors, AMPA, and kainate receptors. |
| PC-26197 |
GluN2B antagonist 22
GluN2B antagonist
|
GluN2B antagonist 22 (MK-22) is a highly potent, GluN2B (NR2B)-selective NMDA receptor antagonist with IC50/Ki of 1.0 nM and 0.88 nM, respectively. |
| PC-26196 |
EVT-101
GluN2B antagonist
|
EVT-101 is a highly potent, selective and orally active GluN2B antagonist with IC50 of 12 nM for GluN1/GluN2B. |
| PC-26195 |
R-(+)-EU-1180-453
GluN2C/D PAM
|
R-(+)-EU-1180-453 is a potent, second-generation GluN2C/D-selective NMDAR-positive allosteric modulator (PAM), with no effect on GluN1/GluN2A and GluN1/GluN2B. |
| PC-26194 |
EU93-31
GluN2B antagonist
|
EU93-31 is a potent, pH-sensitive GluN2B-selective antagonist of NMDA receptor with IC50 of 0.19 uM (GluN1/GluN2B, pH=6.9) and 1.8 uM (GluN1/GluN2B, pH=7.6). |
| PC-26193 |
EU93-108
GluN2B NAM
|
EU93-108 is a potent, brain penetrant GluN2B-selective negative allosteric modulator (NAM) of NMDA receptor with IC50 of 0.557 uM (GluN1/GluN2B), with limited activity against GluN1/GluN2A, GluN1/GluN2C and GluN1/GluN2D |
| PC-26192 |
UCM-101
GluN2A NAM
|
UCM-101 is a potent, selective negative allosteric modulator of GluN2A-containing NMDA receptors with IC50 of 0.11 uM for GluN1/2A, 17-, 35-, and 118-fold selective for GluN1/2A over GluN1/2B, GluN1/2C, and GluN1/2D receptors, respectively. |
| PC-26121 |
UCM-A86
GluN3 NMDA receptor PAM
|
UCM-A86 is a selective positive allosteric modulator (PAM) of GluN1/GluN3 NMDA receptors with EC50 of 21 μM and 19 μM at GluN1/GluN3A and GluN1/GluN3B receptors, respectively, selective over GluN1/GluN2A-D receptors. |
| PC-25808 |
Radiprodil
GluN2B antagonist
|
Radiprodil (RGH-896) is a selective, negative allosteric modulator / antagonist of GluN2B-containing NMDA receptors (GluN2B) with IC50 of 3-10 nM, with no activity against NR2A receptors. |
| PC-25676 |
Fanapanel
AMPA antagonist
|
Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonis with Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. |
| PC-25186 |
GluN2A PAM Y36
GluN2A PAM
|
GluN2A PAM Y36 is a potent, GluN2A-selective N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulator with EC50 of 24.97 uM, Emax=397.7%. |
| PC-25185 |
GNE-3419
GluN2A PAM
|
GNE-3419 is a potent, GluN2A-selective NMDA receptor (NMDAR) positive allosteric modulator with EC50 of 1.9 uM, Emax=150%, 10-fold lower with GluN2D. |
