| Cat. No. |
Product Name |
Information |
| PC-22454 |
GNE-6901
GluN2A PAM
|
GNE-6901 is a selective GluN2A containing NMDAR positive allosteric modulator (PAM) wIth EC50 of 382 nM, binds to the GluN1/GluN2A LBD dimer interface. |
| PC-22453 |
GNE-8324
GluN2A PAM
|
GNE-8324 is a selective GluN2A containing NMDAR positive allosteric modulator (PAM), binds to the GluN1/GluN2A LBD dimer interface. |
| PC-22452 |
Apimostinel
NMDAR agonist
|
Apimostinel (NRX-1074; AGN-241660) is a potential, orally active antidepressant and NMDAR partial agonist. |
| PC-22451 |
MPX-007
GluN2A antagonist
|
MPX-007 is a selective GluN2A antagonist, inhibits GluN2A-containing NMDA receptors expressed in HEK cells with IC50 of 27 nM. |
| PC-22449 |
TCN213
GluN2A antagonist
|
TCN213 is a selective, glycine-dependently GluN2A-containing NMDARs antagonist with IC50 of 0.55 uM for GluN1/GluN2A NMDAR, negligible effect on GluN1/GluN2B NMDA receptor. |
| PC-22425 |
CX1739
AMPAR modulator
|
CX1739 is a small molecule AMPAR allosteric modulator. |
| PC-22159 |
HU-210
NMDAR antagonist
|
HU-211 is a functional N-methyl-D-aspartate receptor blocker with IC50 of 6-10 uM for glutamate- or glycine-induced binding. |
| PC-21397 |
(R)-OF-NB1
NMDAR antagonist
|
(R)-OF-NB1 is a small molecule splice variant GluN2B-selective NMDAR antagonist with IC50 of 675 nM and 97 nM for F-NB1 for splice variant containing exon 5 and GluN1-1a in X. laevis oocytes. |
| PC-21036 |
GluN2B NAM 12
GluN2B NAM
|
GluN2B NAM 12 (GluN2B negative allosteric modulator 12) is a selective negative allosteric modulator of GluN2B NMDAR with IC50 of 31 nM and Ki of 15 nM (hGluN2B). |
| PC-21034 |
UBP141
GluN2C/2D antagonist
|
UBP141 is a selective GluN2C/2D-containing NMDA receptors antagonist with Kd values of 2.8 and 4.2 uM respecitvely, shows weaker activities against GluN2A and 2B (Kd=14.2 and 19.3 uM). |
| PC-21033 |
UBP791
GluN2C/2D antagonist
|
UBP791 is a subtype-selective competitive antagonist of GluN2C/2D-containing NMDA receptors with Ki of 80-90 nM, 50-fold selectivity over GluN2A and GluN2B. |
| PC-21032 |
UBP1700
GluN2C/2D antagonist
|
UBP1700 is a subtype-selective competitive antagonist of GluN2C/2D-containing NMDA receptors with Ki of 7-9 nM, 50-fold selectivity over GluN2A and GluN2B. |
