| Cat. No. |
Product Name |
Information |
| PC-45091 |
NS-1643
hERG activator
|
A small molecule activator of hERG channels that enhances the magnitude of wild-type hERG current in a concentration- and voltage-dependent manner with EC50 of 10.4 uM at -10 mV. |
| PC-45127 |
Flupirtine
Kv7 activator
|
A selective neuronal potassium channel (KCNQ/KV7 channel) activator that also has indirect NMDA receptor antagonist and GABAA receptor modulatory properties. |
| PC-45126 |
Flupirtine maleate
Kv7 activator
|
Flupirtine maleate (D-9998) is a selective neuronal potassium channel (KCNQ/KV7 channel) activator that also has indirect NMDA receptor antagonist and GABAA receptor modulatory properties. |
| PC-42069 |
PAP-1
Kv1.3 inhibitor
|
PAP-1 is a potent, selective small molecule lymphocyte K+ channel Kv1.3 blocker with EC50 of 2 nM. |
| PC-45844 |
Senicapoc
KCa3.1 inhibitor
|
Senicapoc (ICA-17043) is a potent, selective Gardos channel (KCa3.1) blocker that blocks Ca(2+)-induced rubidium flux from human RBCs (IC50=11 nM) and inhibits RBC dehydration (IC50=10-50 nM). |
| PC-42381 |
GAL-021
BKCa inhibitor
|
GAL-021 is a respiratory stimulant that acts as a potent calcium-activated potassium (BKCa, KCa1.1) channel blocker blocker. |
| PC-47402 |
Quinidine
|
A class I antiarrhythmic agent (Ia) that works by blocking the fast inward sodium current (INa). |
| PC-22574 |
ASP0819
KCa3.1 opener
|
ASP0819 is a potent, selective and orally active intermediate conductance channel KCa3.1 (IK1) opener with EC50 and Emax values of 102.4 nM and 99.0%, and 392.9 nM and 102.4% in human and rat KCa3.1-expressing cells, respectively. |
| PC-22563 |
VU0948578
KNa1.1 (Slack) inhibitor
|
VU0948578 is a potent, selective inhibitor of WT, A934T, and G288S SLACK channel (KCNT1, KNa1.1) with IC50 of 0.70, 0.59, 0.71 µM respectively. |
| PC-22457 |
BMS-986308
ROMK inhibitor
|
BMS-986308 is a potent, selective inhibitor of renal outer medullary potassium (ROMK, Kir1.1, KCNJ1) channel with IC50 of 24 nM. |
| PC-22388 |
CPK20
KNa1.1 (Slack) inhibitor
|
CPK20 is a potent, selective inhibitor / blocker of potassium (K+) channel KCNT1 (KNa1.1, Slo2.2, SLACK) with IC50 of 6.4 uM in fluorescence-based assay FluxOR. |
| PC-22344 |
CVN293
THIK-1 inhibitor
|
CVN293 (CVN-293) is a potent, selective and brain permeable potassium (K+) ion channel KCNK13 (THIK-1, K2P13.1) inhibitor with IC50 of 41 nM and 28 nM for human and mouse KCNK13, respectively. |
