| Cat. No. |
Product Name |
Information |
| PC-60781 |
SKA-111
KCa3.1 activator
|
SKA-111 is a potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM. |
| PC-60780 |
SKA-121
KCa3.1 activator
|
SKA-121 is a potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 109 nM. |
| PC-60688 |
BMS-204352
Potassium channel opener
|
Flindokalner (BMS-204352) is a potent and effective calcium-sensitive opener of maxi-K potassium channels (maxi-K) with EC50 of 392 nM at -48.4 mV in HEK293 isolated outside-out membrane patches. |
| PC-60687 |
DMP543
Kv7 inhibitor
|
DMP543 (XR-543) is a potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM. |
| PC-60686 |
XE 991 dihydrochloride
Kv7 inhibitor
|
XE 991 dihydrochloride is a potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively. |
| PC-60655 |
Charybdotoxin
BKCa inhibitor
|
Charybdotoxin (ChTX) selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK). |
| PC-60654 |
Iberiotoxin
BKCa inhibitor
|
Iberiotoxin (IbTX) is a selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK) with IC50 of 0.25 nM. |
| PC-60653 |
NS19504
BKCa activator
|
A novel selective, small molecule large-conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1, MaxiK) positive modulator with EC50 of 11 uM. |
| PC-60648 |
AUT2
Kv3 modulator
|
AUT2 is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 0.9 and 1.9 uM for Kv3.1b and Kv3.2a, respectively. |
| PC-60647 |
AUT1
Kv3 modulator
|
AUT1 (AUT-1) is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively. |
| PC-60576 |
ML418
Kir7.1 inhibitor
|
ML418 (ML-418) is the first potent, selective, CNS penetrating inward rectifier potassium channel Kir7.1 (KCNJ13) inhibitor with IC50 of 0.31 uM. |
| PC-60575 |
BNBI
ROMK inhibitor
|
BNBI is a selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 8 uM in T1+ flux assays, does not inhibit Kir7.1 at 100 uM. |
