| Cat. No. |
Product Name |
Information |
| PC-27817 |
GPR37L1 agonist P06
GPR37L1 agonist
|
GPR37L1 agonist P06 is a potent, small-molecule agonist of G protein-coupled receptor GPR37-like 1 (GPR37L1), induces dose-dependent potassium influx with EC50 of 182.4 nM in thallium (Tl+) influx assay using HEK293 cells expressing GPR37L1 and the KCNJ3 channel, exhibits significant analgesic effects. |
| PC-27789 |
RL648_81
Kv7.2/7.3 activator
|
RL648_81 (RL648-81, RL-81) is a potent subtype-selective KCNQ2/3 (Kv7.2/7.3) channel activator with EC50 of 190 nM, >15 times more potent and also more selective than retigabine. |
| PC-27788 |
HN37
Kv7.2/7.3 activator
|
Pynegabine (HN37) is a novel, next-generation positive allosteric modulator/activator of KCNQ2/3 (Kv7.2/7.3) potassium with EC50 of 37 nM ( KCNQ2), shows antiepileptic activity. |
| PC-27688 |
AUT00206
Kv3.1/3.2 modulator
|
AUT00206 (AUT6) is a specific positive allosteric modulator modulator of Kv3.1/3.2 potassium channels. |
| PC-27005 |
K2P16-i7-4
TALK-1 inhibitor
|
K2P16-i7-4 is a potent, selective, reversible inhibitor of two-pore domain K+ (K2P) channel TALK-1 with IC50 of 1.61 uM, enhances [Ca2+]ER storage in T-REx-TALK-1 cells. |
| PC-27004 |
K2P16-i7
TALK-1 inhibitor
|
K2P16-i7 (VU0544194) is a potent, selective, reversible inhibitor of two-pore domain K+ (K2P) channel TALK-1 with IC50 of 5.2 uM, promotes β-cell function. |
| PC-26897 |
Zinc13732787
KCNQ1/Kv7.1 inhibitor
|
Zinc13732787 is a selective inhibitor of KCNQ1/Kv7.1 potassium channel, without affecting KCNQ2/KCNQ3. |
| PC-26855 |
VU0521426
Kv3.1 channel inhibitor
|
VU0521426 (VU426) is a potent, selective Kv3.1 channel inhibitor with IC50 of 4.3 uM, suppresses Kv3.1 activity through a state-dependent mechanism consistent with stabilization of non-conducting channel states. |
| PC-26104 |
ztz240
KCNQ2 activator
|
ztz240 is a potent, selective activator of KCNQ2 potassium channel (Kv7.2) with EC50 of 5.8 uM on outward current of KCNQ2 channels. |
| PC-25469 |
DCY1040
TMEM175 agonist
|
DCY1040 is a potent, specific small molecule agonist of transmembrane protein 175 (TMEM175) with EC50 of 3.0 uM and 105.9-fold potentiation, directly binds to TMEM175. |
| PC-24597 |
ONO-TR-772
TERK inhibitor
|
ONO-TR-772 (VU6018042) is a potent, selective and CNS penetrant TREK (TWIK related K+ channel) inhibitor with IC50 of 15 nM (TREK-1, human manual patch clamp (MPC)), equipotent with TREK-2. |
| PC-24526 |
DHP-103
KCa3.1 inhibitor
|
DHP-103 is a potent, highly selective inhibitor of intermediate-conductance calcium-activated K+ channel KCa3.1 with IC50 of 6.1 nM, exhibits exquisite selectivity over calcium channels and a panel of >100 additional molecular targets. |
