| Cat. No. |
Product Name |
Information |
| PC-21733 |
VU0542270
Kir6.1/SUR2B inhibitor
|
VU0542270 is the first selective inhibitor of vascular Kir6.1/SUR2B KATP channel with IC50 of 129 nM, >300-fold selective over other members of the Kir channel family. |
| PC-20745 |
LAKI
TREK channel inhibitor
|
LAKI (Light Activated K+ channel Inhibitor) is a specific photoswitchable inhibitor of the pain-related two-pore-domain potassium (K2P) TREK and TRESK channels. |
| PC-20299 |
GIRK1/4 inhibitor 14b
GIRK1/4 inhibitor
|
GIRK1/4 inhibitor 14b is a potent, brain-sparing GIRK1/4 inhibitor with IC50 of 0.1 uM, exhibits excellent selectivity over GIRK1/2 channel. |
| PC-20298 |
NIP-142
Kv1.5 inhibitor
|
NIP-142 (NIP142) is an anti-arrhythmic agent by targeting cardiac K+ channel Kv1.5 (Kv1.5) currents, inhibits the steady-state phase with IC50 of 4.75 uM. |
| PC-49848 |
VU0546110
Sperm SLO3 channel inhibitor
|
VU0546110 (VU 0546110) is a potent, selective inhibitor of the sperm-specific potassium channel SLO3 with IC50 of 1.29 uM, impairs sperm function. |
| PC-49839 |
Retigabine
Kv7 opener
|
Retigabine (D-23129, XEN496) is an anticonvulsant compound and KV7 channel agonist (opener), enhances activation of KCNQ2/Q3 potassium channels. |
| PC-49796 |
ACOU085
KV7.4 activator
|
ACOU085 (ACOU 085) is a potent small-molecule agonist of Kv7.4 (KCNQ4) channel with higher potency than ML-213 in the nanomolar range. |
| PC-49538 |
SCR2682
Kv.7 activator
|
SCR2682 is a potent, selective neuronal voltage-gated potassium Kv7/KCNQ/M channel opener (activator) with EC50 of 9.8 nM (Kv7.2/Kv7.3), 100-fold more potency than retigabine. |
| PC-49468 |
TASK inhibitor F3
TASK Channel inhibitor
|
TASK inhibitor F3 is a potent, selective blocker of TWIK-related acid-sensitive K+ (TASK) channels with IC50 of 148 nM (TASK-1). |
| PC-49461 |
C101248
THIK-1 inhibitor
|
C101248 is the first selective small-molecule inhibitor of tandem pore domain halothane-inhibited K+ channel 1 (THIK-1) with IC50 of 50 nM for both mouse and human THIK-1. |
| PC-47105 |
TTQC-1
BKCa activator
|
TTQC-1 is a potent activator of the large-conductance Ca2+-activated K+ channel (BKCa channel), directly and reversibly activates the macroscopic current of BKCa channels expressed in Xenopus oocytes from both sides of the cellular membrane, increases the maximum conductance and shifted the half activation voltage to the left with EC50 of 2.8 uM. |
| PC-47099 |
SKA-31
KCa2/KCa3.1 activator
|
SKA-31 is a small molecule activator of KCa2 and KCa3.1 potassium channels with EC50 values of 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively. |
