| Cat. No. |
Product Name |
Information |
| PC-45471 |
Azimilide
hERG inhibitor
|
Azimilide (NE-10064) is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel, blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively. |
| PC-47402 |
Quinidine
|
A class I antiarrhythmic agent (Ia) that works by blocking the fast inward sodium current (INa). |
| PC-23682 |
Vernakalant hydrochloride
K+ channel blocker
|
Vernakalant (RSD1235) is an atrial-selective antifibrillatory agent and mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker, inhibits wild-type and mutant Kv1.5 channels. |
| PC-23631 |
GiGA1
GIRK1/2 activator
|
GiGA1 is a selective G-protein-independent activator of GIRK channels, targets the alcohol pocket and specifically activates GIRK1/GIRK2 with EC50 of 31 uM. |
| PC-23611 |
VU0134992 hydrochloride
Kir4.1 inhibitor
|
VU0134992 hydrochloride(VU 0134992) is a potent, selective blocker of the inward rectifier potassium channel Kir4.1 (KCNJ10) with IC50 of 0.97 uM in whole-cell patch clamp electrophysiology assays. |
| PC-23603 |
SKA-346
KCa3.1 activator
|
SKA-346 is a selective activator of calcium-activated KCa3.1 channel with EC50 of 1.9 uM, does not activate KCa1.1, KCa2.2 and KCa2.3 up to 30 uM. |
| PC-23274 |
VU0531245
KNa1.1 (Slack) inhibitor
|
VU0531245 (VU245) is a potent, selective SLACK channel (KNa1.1) inhibitor, inhibits WT SLACK channels with IC50 of 2.1 uM. |
| PC-23273 |
KNa1.1 blocker Z05
KNa1.1 (Slack) inhibitor
|
KNa1.1 blocker Z05 is a selective potential KNa1.1 (Slack, Slo2.2, or KCa4.1) inhibitor with IC50 of 3.4 uM and 0.2 uM for WT KNa1.1 and mutant Y796H respectively. |
| PC-23263 |
C28
KCNQ1 activator
|
C28 is a specific small molecule activator of cardiac potassium ion channel IKs (KCNQ1+KCNE1), causes change of V1/2 of G-V relations with EC50 of 7.6 uM, interacts with the KCNQ1 voltage-sensing domain (VSD), and shifts voltage dependence of VSD activation to more negative voltages. |
| PC-23125 |
SZV-2649
Potassium channel activator
|
SZV-2649 is a small molecule multiple ion channel inhibitor, inhibits hERG and GIRK currents in HEK cells with IC50 of 342 and 529 nM respectively, shows antiarrhythmic effects. |
| PC-22989 |
BA6b9
SK4 channel blocker
|
BA6b9 is a small molecule, allosteric SK4 channel blocker, reversibly inhibits the SK4 currents with IC50 of 8.6 uM, targets Ca2+-calmodulin (CaM)-PIP2-binding domain. |
| PC-22937 |
Tertiapin-Q
GIRK channel inhibitor
|
Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and renal outer medullary potassium channel (ROMK1, Kir1.1), blocks recombinant and native large conductance K+ channels. |
