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Cat. No. Product Name Information
PC-45471

Azimilide

hERG inhibitor

Azimilide (NE-10064) is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel, blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively.
PC-47402

Quinidine

A class I antiarrhythmic agent (Ia) that works by blocking the fast inward sodium current (INa).
PC-24166

Opakalim

Kv7 activator

Opakalim is a potent, selective small molecule activator of Kv7 potassium channel.
PC-24079

ONO-2920632

TREK-2 activator

ONO-2920632 (VU6011887) is a potent, highly selective and CNS penetrant TREK-2 (TWIK-related K+ channel 2, K2P10.1) activator with EC50 of 0.3 uM (Emax=184%).
PC-23869

Ebio3

KCNQ2 inhibitor

Ebio3 is a potent, subtype-selective inhibitor of potassium channel KCNQ2 (Kv7.2), efficiently suppresses KCNQ2 currents with IC50 of 1.2 nM.
PC-23868

Ebio2

KCNQ2 activator

Ebio2 is a potent, subtype-selective activator of potassium channel KCNQ2 (Kv7.2) with EC50 of 1.9 nM for activation on the outward current amplitude of the KCNQ2 channel at +50 mV.
PC-23682

Vernakalant hydrochloride

K+ channel blocker

Vernakalant (RSD1235) is an atrial-selective antifibrillatory agent and mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker, inhibits wild-type and mutant Kv1.5 channels.
PC-23631

GiGA1

GIRK1/2 activator

GiGA1 is a selective G-protein-independent activator of GIRK channels, targets the alcohol pocket and specifically activates GIRK1/GIRK2 with EC50 of 31 uM.
PC-23611

VU0134992 hydrochloride

Kir4.1 inhibitor

VU0134992 hydrochloride(VU 0134992) is a potent, selective blocker of the inward rectifier potassium channel Kir4.1 (KCNJ10) with IC50 of 0.97 uM in whole-cell patch clamp electrophysiology assays.
PC-23603

SKA-346

KCa3.1 activator

SKA-346 is a selective activator of calcium-activated KCa3.1 channel with EC50 of 1.9 uM, does not activate KCa1.1, KCa2.2 and KCa2.3 up to 30 uM.
PC-23274

VU0531245

KNa1.1 (Slack) inhibitor

VU0531245 (VU245) is a potent, selective SLACK channel (KNa1.1) inhibitor, inhibits WT SLACK channels with IC50 of 2.1 uM.
PC-23273

KNa1.1 blocker Z05

KNa1.1 (Slack) inhibitor

KNa1.1 blocker Z05 is a selective potential KNa1.1 (Slack, Slo2.2, or KCa4.1) inhibitor with IC50 of 3.4 uM and 0.2 uM for WT KNa1.1 and mutant Y796H respectively.

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