| Cat. No. |
Product Name |
Information |
| PC-23273 |
KNa1.1 blocker Z05
KNa1.1 (Slack) inhibitor
|
KNa1.1 blocker Z05 is a selective potential KNa1.1 (Slack, Slo2.2, or KCa4.1) inhibitor with IC50 of 3.4 uM and 0.2 uM for WT KNa1.1 and mutant Y796H respectively. |
| PC-23263 |
C28
KCNQ1 activator
|
C28 is a specific small molecule activator of cardiac potassium ion channel IKs (KCNQ1+KCNE1), causes change of V1/2 of G-V relations with EC50 of 7.6 uM, interacts with the KCNQ1 voltage-sensing domain (VSD), and shifts voltage dependence of VSD activation to more negative voltages. |
| PC-23125 |
SZV-2649
Potassium channel activator
|
SZV-2649 is a small molecule multiple ion channel inhibitor, inhibits hERG and GIRK currents in HEK cells with IC50 of 342 and 529 nM respectively, shows antiarrhythmic effects. |
| PC-22989 |
BA6b9
SK4 channel blocker
|
BA6b9 is a small molecule, allosteric SK4 channel blocker, reversibly inhibits the SK4 currents with IC50 of 8.6 uM, targets Ca2+-calmodulin (CaM)-PIP2-binding domain. |
| PC-22937 |
Tertiapin-Q
GIRK channel inhibitor
|
Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and renal outer medullary potassium channel (ROMK1, Kir1.1), blocks recombinant and native large conductance K+ channels. |
| PC-22929 |
TMEM175 inhibitor AP-6
TMEM175 inhibitor
|
TMEM175 inhibitor AP-6 is a selective TMEM175 inhibitor, increases lysosomal degradative activity. |
| PC-22928 |
2-PPA
TMEM175 inhibitor
|
2-PPA is a selective TMEM175 inhibitor with IC50 of 31 uM, 26-fold selectivity for TMEM175 compared to hKv3.1, increases lysosomal degradative activity. |
| PC-22741 |
CAT335
TREK-1 activator
|
CAT335 is a small molecule covalent K2P2.1 (TREK-1) channel activator, selectively and irreversibly activates K2P2.1(TREK-1) S131C variant (TREK-1CG∗), but not wild-type K2P2.1(TREK-1) |
| PC-22728 |
Nigericin
Potassium ionophore, NLRP3 agonist
|
Nigericin (NSC 292567) is an ionophore antibiotic derived from S. hygroscopicus that acts as a potassium ionophore promoting K+/H+ exchange across mitochondrial membranes. |
| PC-22574 |
ASP0819
KCa3.1 opener
|
ASP0819 is a potent, selective and orally active intermediate conductance channel KCa3.1 (IK1) opener with EC50 and Emax values of 102.4 nM and 99.0%, and 392.9 nM and 102.4% in human and rat KCa3.1-expressing cells, respectively. |
| PC-22563 |
VU0948578
KNa1.1 (Slack) inhibitor
|
VU0948578 is a potent, selective inhibitor of WT, A934T, and G288S SLACK channel (KCNT1, KNa1.1) with IC50 of 0.70, 0.59, 0.71 µM respectively. |
| PC-22457 |
BMS-986308
ROMK inhibitor
|
BMS-986308 is a potent, selective inhibitor of renal outer medullary potassium (ROMK, Kir1.1, KCNJ1) channel with IC50 of 24 nM. |
