| Cat. No. |
Product Name |
Information |
| PC-21229 |
VU0935685
KNa1.1 (Slack) inhibitor
|
VU0935685 is a potent, selective inhibitor of SLACK potassium channels with IC50 of 0.32 uM in in whole-cell, voltage-clamp electrophysiology (EP) assays, demonstrates selectivity versus hERG. |
| PC-20943 |
ML252
KCNQ2 inhibitor
|
ML252 is a potent and selective, brain penetrant inhibitor of KCNQ2 (Kv 7.2) with IC50 of 69 nM, EC50 of 170 nM. |
| PC-20753 |
BK channel modulator BC5
BK channel modulator
|
BK channel modulator BC5 is an allosteric modulator of BK type Ca2+-activated K+ channels, interacts with the CTD-VSD interface and specifically modulates the Ca2+ dependent activation mechanism. |
| PC-20702 |
ML308
KCNK9 inhibitor
|
ML308 (ML 308) is a potent, selective inhibitor of two-pore domain potassium channel KCNK9 (TASK-3, K2P9.1) with IC50 of 130 nM in thallium influx fluorescent assays and 413 nM in automated electrophysiology assays, respectively. |
| PC-20698 |
PK-THPP
TASK-3 inhibitor
|
TASK-3 inhibitor 23 is a potent, selective inhibitor of TWIK-related acid-sensitive K+ (K2P9.1, TASK-3) ion channel with IC50 of 30 nM, 10-fold selectivity over TASK-1. |
| PC-20697 |
A1899
TASK-1 inhibitor
|
A1899 (A-1899) is a potent and highly selective blocker of the K(2P) channel TASK-1, selectively blocks human TASK-1 channels expressed in Xenopus oocytes with IC50 of 35.1 nM. |
| PC-20299 |
GIRK1/4 inhibitor 14b
GIRK1/4 inhibitor
|
GIRK1/4 inhibitor 14b is a potent, brain-sparing GIRK1/4 inhibitor with IC50 of 0.1 uM, exhibits excellent selectivity over GIRK1/2 channel. |
| PC-20298 |
NIP-142
Kv1.5 inhibitor
|
NIP-142 (NIP142) is an anti-arrhythmic agent by targeting cardiac K+ channel Kv1.5 (Kv1.5) currents, inhibits the steady-state phase with IC50 of 4.75 uM. |
| PC-49839 |
Retigabine
Kv7 opener
|
Retigabine (D-23129, XEN496) is an anticonvulsant compound and KV7 channel agonist (opener), enhances activation of KCNQ2/Q3 potassium channels. |
| PC-49797 |
ACOU001
KV7.4 activator
|
ACOU001 (ACOU 001) is a potent small-molecule agonist of Kv7.4 (KCNQ4) channel with potential effect against ge-related hearing loss (ARHL) and other hearing impairments related to compromised KV7.4 function. |
| PC-49468 |
TASK inhibitor F3
TASK Channel inhibitor
|
TASK inhibitor F3 is a potent, selective blocker of TWIK-related acid-sensitive K+ (TASK) channels with IC50 of 148 nM (TASK-1). |
| PC-38848 |
KV10.1 inhibitor compound 1
Kv10.1 inhibitor
|
KV10.1 inhibitor compound 1 is a selective inhibitor of the voltage-gated potassium channel KV10.1 with IC50 of 740 nM. |
