| Cat. No. |
Product Name |
Information |
| PC-45126 |
Flupirtine maleate
Kv7 activator
|
Flupirtine maleate (D-9998) is a selective neuronal potassium channel (KCNQ/KV7 channel) activator that also has indirect NMDA receptor antagonist and GABAA receptor modulatory properties. |
| PC-42069 |
PAP-1
Kv1.3 inhibitor
|
PAP-1 is a potent, selective small molecule lymphocyte K+ channel Kv1.3 blocker with EC50 of 2 nM. |
| PC-45844 |
Senicapoc
KCa3.1 inhibitor
|
Senicapoc (ICA-17043) is a potent, selective Gardos channel (KCa3.1) blocker that blocks Ca(2+)-induced rubidium flux from human RBCs (IC50=11 nM) and inhibits RBC dehydration (IC50=10-50 nM). |
| PC-42381 |
GAL-021
BKCa inhibitor
|
GAL-021 is a respiratory stimulant that acts as a potent calcium-activated potassium (BKCa, KCa1.1) channel blocker blocker. |
| PC-45472 |
Azimilide dihydrochloride
hERG inhibitor
|
Azimilide dihydrochloride is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel; blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively. |
| PC-45471 |
Azimilide
hERG inhibitor
|
Azimilide (NE-10064) is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel, blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively. |
| PC-47402 |
Quinidine
|
A class I antiarrhythmic agent (Ia) that works by blocking the fast inward sodium current (INa). |
| PC-24784 |
Zj7923
Kv2.1
|
Zj7923 is a potent, selective voltage-dependent potassium channel Kv2.1 blocker with IC50 of 0.12 uM, >130-fold selectivity for Kv2.1 over Kv1.5, Kv3.1, hERG, TREK-1. |
| PC-24770 |
LPS2336
TREK-1 activator
|
LPS2336 is a potent TREK-1 (K2P2.1) activator with EC50 of 11.76 uM, LPS2336 (50 uM) increases the mean current density recorded at 0 mV in HEK-hTREK-1 cells by 10.77-fold using patch clamp assays. |
| PC-24598 |
TKIM
TREK-1 inhibitor
|
TKIM is a small molecule TREK-1 channel inhibitor with an IC50 of 2.96 μM, binds to the pocket of the intermediate (IM) state of TREK-1. |
| PC-24597 |
ONO-TR-772
TERK inhibitor
|
ONO-TR-772 (VU6018042) is a potent, selective and CNS penetrant TREK (TWIK related K+ channel) inhibitor with IC50 of 15 nM (TREK-1, human manual patch clamp (MPC)), equipotent with TREK-2. |
| PC-24563 |
ROMK inhibitor Compound A
ROMK inhibitor
|
ROMK inhibitor Compound A is a potent, highly selective inhibitor renal outer medullary potassium (ROMK, Kir1.1) channel with IC50 of 24 nM, displays good selectivity across other ion channel superfamilies. |
