| Cat. No. |
Product Name |
Information |
| PC-45471 |
Azimilide
hERG inhibitor
|
Azimilide (NE-10064) is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel, blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively. |
| PC-47402 |
Quinidine
|
A class I antiarrhythmic agent (Ia) that works by blocking the fast inward sodium current (INa). |
| PC-24166 |
Opakalim
Kv7 activator
|
Opakalim is a potent, selective small molecule activator of Kv7 potassium channel. |
| PC-24079 |
ONO-2920632
TREK-2 activator
|
ONO-2920632 (VU6011887) is a potent, highly selective and CNS penetrant TREK-2 (TWIK-related K+ channel 2, K2P10.1) activator with EC50 of 0.3 uM (Emax=184%). |
| PC-23869 |
Ebio3
KCNQ2 inhibitor
|
Ebio3 is a potent, subtype-selective inhibitor of potassium channel KCNQ2 (Kv7.2), efficiently suppresses KCNQ2 currents with IC50 of 1.2 nM. |
| PC-23868 |
Ebio2
KCNQ2 activator
|
Ebio2 is a potent, subtype-selective activator of potassium channel KCNQ2 (Kv7.2) with EC50 of 1.9 nM for activation on the outward current amplitude of the KCNQ2 channel at +50 mV. |
| PC-23682 |
Vernakalant hydrochloride
K+ channel blocker
|
Vernakalant (RSD1235) is an atrial-selective antifibrillatory agent and mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker, inhibits wild-type and mutant Kv1.5 channels. |
| PC-23631 |
GiGA1
GIRK1/2 activator
|
GiGA1 is a selective G-protein-independent activator of GIRK channels, targets the alcohol pocket and specifically activates GIRK1/GIRK2 with EC50 of 31 uM. |
| PC-23611 |
VU0134992 hydrochloride
Kir4.1 inhibitor
|
VU0134992 hydrochloride(VU 0134992) is a potent, selective blocker of the inward rectifier potassium channel Kir4.1 (KCNJ10) with IC50 of 0.97 uM in whole-cell patch clamp electrophysiology assays. |
| PC-23603 |
SKA-346
KCa3.1 activator
|
SKA-346 is a selective activator of calcium-activated KCa3.1 channel with EC50 of 1.9 uM, does not activate KCa1.1, KCa2.2 and KCa2.3 up to 30 uM. |
| PC-23274 |
VU0531245
KNa1.1 (Slack) inhibitor
|
VU0531245 (VU245) is a potent, selective SLACK channel (KNa1.1) inhibitor, inhibits WT SLACK channels with IC50 of 2.1 uM. |
| PC-23273 |
KNa1.1 blocker Z05
KNa1.1 (Slack) inhibitor
|
KNa1.1 blocker Z05 is a selective potential KNa1.1 (Slack, Slo2.2, or KCa4.1) inhibitor with IC50 of 3.4 uM and 0.2 uM for WT KNa1.1 and mutant Y796H respectively. |
