| Cat. No. |
Product Name |
Information |
| PC-63067 |
Linopirdine
Kv7 inhibitor
|
Linopirdine (DUP-996, Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blocker. |
| PC-63066 |
XE991
Kv7 inhibitor
|
XE991 is a potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively. |
| PC-62919 |
CP-339818
Kv1.3 inhibitor
|
CP-339818 is a potent, selective, non-peptide KV1.3 channel antagonist with IC50 of 200 nM. |
| PC-62832 |
ROMK-IN-32
ROMK inhibitor
|
ROMK-IN-32 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 17 nM. |
| PC-62819 |
ZINC12427628
|
ZINC12427628 (Compound '628) is a potent, selective positive allosteric modulator of M2 mAChR with EC50 of 1.1 uM. |
| PC-62817 |
AVE-0118
Kv1.5 inhibitor
|
AVE-0118 is a potent I(to)/I(Kur) blocker, Kv1.5 channel inhibitor with IC50 of 5.6 uM, also blocks Kv1.3, Kv2.1, Kv3.1, and Kv4.3 channels with similar potency. |
| PC-62816 |
MK-0448
Kv1.5 inhibitor
|
MK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM. |
| PC-62815 |
MK-1832
Kv1.5 inhibitor
|
MK-1832 is a potent, selective Kv1.5 inhibitor with IC50 of 86 nM, exhibits improved selectivity for IKur over IKs (>3000-fold) compares with MK-0448 (70-fold). |
| PC-62794 |
ROMK-IN-25
ROMK inhibitor
|
ROMK-IN-25 is a potent and selective renal outer medullary potassium channel (ROMK, Kir1.1, KCNJ1) inhibitor with IC50 of 72 nM. |
| PC-62767 |
BMS-919373
Kv1.5 inhibitor
|
BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM, with selectivity versus hERG, Na, Ca channels and reduced the level of brain penetration. |
| PC-62646 |
PAPTP
Kv1.3 inhibitor
|
PAPTP is a PAP-1 derivative, potent, specific Kv1.3 channel inhibitor with IC50 of 31 nM in Jurkat T lymphocytes by patch-clamp, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM. |
| PC-62645 |
PCARBTP
Kv1.3 inhibitor
|
PCARBTP is a derivative, potent, specific Kv1.3 channel inhibitor, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM. |
