| Cat. No. |
Product Name |
Information |
| PC-35863 |
VU0466551
GIRK activator
|
VU0466551 (VU-0466551) is a potent, selective, small-molecule GIRK activator with EC50 of 70.6 nM (GIRK1/2 channels). |
| PC-35862 |
VU0529331
GIRK1 activator
|
VU0529331 (VU 0529331) is the first synthetic small molecule activator of non-GIRK1-containing GIRK (non-GIRK1/X) channels with EC50 of 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, respectively. |
| PC-35564 |
AP14145
KCa2.2/KCa2.3 inhibitor
|
AP14145 (AP-14145) is a potent, selective negative allosteric modulator of KCa2.2 and KCa2.3 with equal potency (IC50=1.1±0.3 uM). |
| PC-35388 |
IK1 inhibitor PA-6
IK1 inhibitor
|
IK1 inhibitor PA-6 is an efficient, specific inhibitor of inward rectifier current (IK1), blocks KIR2.x currents of human and mouse with IC50 of 12-15 nM. |
| PC-35211 |
VU0134992
Kir4.1 inhibitor
|
VU0134992 (VU 0134992) is a potent, selective blocker of the inward rectifier potassium channel Kir4.1 (KCNJ10) with IC50 of 0.97 uM in whole-cell patch clamp electrophysiology assays. |
| PC-63569 |
BMS-394136
Kv1.5 inhibitor
|
BMS-394136 is a potent, selective IKur/Kv1.5inhibitor, increases atrial action potential duration (APD) and prolongs AERP but not VERP in both rabbits and beagles.. |
| PC-63511 |
LUF7346
hERG modulator
|
LUF7346 is a novel hERG allosteric modulator that slows IKr deactivation and positively shifting IKr inactivation. |
| PC-63348 |
PF-06807656
ROMK inhibitor
|
PF-06807656 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1a) inhibitor with IC50 of 61 nM for hROMK in patch-clamp assays. |
| PC-63222 |
JNJ303
IKs blocker
|
JNJ303 is a potent, specific delayed rectifier potassium current I(Ks) blocker with IC50 of 64 nM, shows no effects on other cardiac channels (IC50=3.3, >10, 11.1 and 12.6 uM for Na, ICa, Ito and IKr currents). |
| PC-63221 |
L-364373
Kv7.1 activator
|
L-364373 (R-L3) is a stereospecific activator of cardiac slowly activating delayed rectifier K+ current (IKs) and KV7.1 (KCNQ1) channels. |
| PC-43063 |
NS-1619
BKCa activator
|
NS-1619 (NS1619) is a selective large-conductance Ca(2+)-dependent K+ channel (BKCa channel) activator with EC50 of 3.6 uM. |
| PC-42995 |
ML365
KCNK3/TASK1 inhibitor
|
ML365 is a potent and selective inhibitor of KCNK3/TASK1 potassium channel, blocks TASK1 channels in both the thallium influx fluorescent assay (IC50=4 nM) and an automated electrophysiology assay (IC50=16 nM). |
