| Cat. No. |
Product Name |
Information |
| PC-42995 |
ML365
KCNK3/TASK1 inhibitor
|
ML365 is a potent and selective inhibitor of KCNK3/TASK1 potassium channel, blocks TASK1 channels in both the thallium influx fluorescent assay (IC50=4 nM) and an automated electrophysiology assay (IC50=16 nM). |
| PC-42992 |
ML277
Kv7.1 activator
|
ML277 (CID53347902) is a potent and selective Kv7.1 (KCNQ1) potassium channel activator with EC50 of 260 nM, displays highly selectivity against other KCNQ channels (>100-fold selectivityover KCNQ2 and KCNQ4). |
| PC-63156 |
E-4031
hERG inhibitor
|
E-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr). |
| PC-63068 |
Linopirdine dihydrochloride
Kv7 inhibitor
|
Linopirdine (DUP-996) dihydrochloride is a potent Kv7 (KCNQ) voltage-gated potassium channels blocker. |
| PC-63067 |
Linopirdine
Kv7 inhibitor
|
Linopirdine (DUP-996, Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blocker. |
| PC-63066 |
XE991
Kv7 (KCNQ) inhibitor
|
XE991 is a potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively. |
| PC-62919 |
CP-339818
Kv1.3 inhibitor
|
CP-339818 is a potent, selective, non-peptide KV1.3 channel antagonist with IC50 of 200 nM. |
| PC-62832 |
ROMK-IN-32
ROMK inhibitor
|
ROMK-IN-32 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 17 nM. |
| PC-62817 |
AVE-0118
Kv1.5 inhibitor
|
AVE-0118 is a potent I(to)/I(Kur) blocker, Kv1.5 channel inhibitor with IC50 of 5.6 uM, also blocks Kv1.3, Kv2.1, Kv3.1, and Kv4.3 channels with similar potency. |
| PC-62816 |
MK-0448
Kv1.5 inhibitor
|
MK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM. |
| PC-62815 |
MK-1832
Kv1.5 inhibitor
|
MK-1832 is a potent, selective Kv1.5 inhibitor with IC50 of 86 nM, exhibits improved selectivity for IKur over IKs (>3000-fold) compares with MK-0448 (70-fold). |
| PC-62794 |
ROMK-IN-25
ROMK inhibitor
|
ROMK-IN-25 is a potent and selective renal outer medullary potassium channel (ROMK, Kir1.1, KCNJ1) inhibitor with IC50 of 72 nM. |
