| Cat. No. |
Product Name |
Information |
| PC-49839 |
Retigabine
Kv7 opener
|
Retigabine (D-23129, XEN496) is an anticonvulsant compound and KV7 channel agonist (opener), enhances activation of KCNQ2/Q3 potassium channels. |
| PC-49797 |
ACOU001
Kv7.4 activator
|
ACOU001 (ACOU 001) is a potent small-molecule agonist of Kv7.4 (KCNQ4) channel with potential effect against ge-related hearing loss (ARHL) and other hearing impairments related to compromised KV7.4 function. |
| PC-49796 |
ACOU085
Kv7.4 activator
|
ACOU085 (ACOU 085) is a potent small-molecule agonist of Kv7.4 (KCNQ4) channel with higher potency than ML-213 in the nanomolar range. |
| PC-49538 |
SCR2682
Kv.7 activator
|
SCR2682 is a potent, selective neuronal voltage-gated potassium Kv7/KCNQ/M channel opener (activator) with EC50 of 9.8 nM (Kv7.2/Kv7.3), 100-fold more potency than retigabine. |
| PC-49468 |
TASK inhibitor F3
TASK Channel inhibitor
|
TASK inhibitor F3 is a potent, selective blocker of TWIK-related acid-sensitive K+ (TASK) channels with IC50 of 148 nM (TASK-1). |
| PC-49461 |
C101248
THIK-1 inhibitor
|
C101248 is the first selective small-molecule inhibitor of tandem pore domain halothane-inhibited K+ channel 1 (THIK-1) with IC50 of 50 nM for both mouse and human THIK-1. |
| PC-47105 |
TTQC-1
BKCa activator
|
TTQC-1 is a potent activator of the large-conductance Ca2+-activated K+ channel (BKCa channel), directly and reversibly activates the macroscopic current of BKCa channels expressed in Xenopus oocytes from both sides of the cellular membrane, increases the maximum conductance and shifted the half activation voltage to the left with EC50 of 2.8 uM. |
| PC-47099 |
SKA-31
KCa2/KCa3.1 activator
|
SKA-31 is a small molecule activator of KCa2 and KCa3.1 potassium channels with EC50 values of 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively. |
| PC-38848 |
KV10.1 inhibitor compound 1
Kv10.1 inhibitor
|
KV10.1 inhibitor compound 1 is a selective inhibitor of the voltage-gated potassium channel KV10.1 with IC50 of 740 nM. |
| PC-38847 |
ZVS-08
Kv10.1 inhibitor
|
ZVS-08 is a selective inhibitor of the voltage-gated potassium channel KV10.1 with IC50 of 3.7 uM. |
| PC-38639 |
3hi2one-G4
GIRK4 activator
|
3hi2one-G4 is a highly selective small molecule activator targeting GIRK4 homomeric channels, does not activate GIRK2, GIRK1/2 or GIRK1/4 channels. |
| PC-38493 |
RY785
Kv2 channel inhibitor
|
RY785 (RY-785) is a potent, selective voltage-gated potassium (Kv2) channels inhibitor with IC50 of 50 nM for Kv2.1 channel, possesses good selectivity over Kv1.2 (IC50>10 uM). |
