| Cat. No. |
Product Name |
Information |
| PC-25403 |
VU625
AeKir1 inhibitor
|
VU625 (VU0077625) is a potent and selective inhibitor of Aedes aegypti Kir1 (AeKir1) channel with IC50 of 96.8 nM in patch clamp electrophysiology experiments of HEK293 cells, selective for AeKir1 over mammalian Kir channels and AeKir2B channel. |
| PC-24784 |
Zj7923
Kv2.1
|
Zj7923 is a potent, selective voltage-dependent potassium channel Kv2.1 blocker with IC50 of 0.12 uM, >130-fold selectivity for Kv2.1 over Kv1.5, Kv3.1, hERG, TREK-1. |
| PC-24770 |
LPS2336
TREK-1 activator
|
LPS2336 is a potent TREK-1 (K2P2.1) activator with EC50 of 11.76 uM, LPS2336 (50 uM) increases the mean current density recorded at 0 mV in HEK-hTREK-1 cells by 10.77-fold using patch clamp assays. |
| PC-24598 |
TKIM
TREK-1 inhibitor
|
TKIM is a small molecule TREK-1 channel inhibitor with an IC50 of 2.96 μM, binds to the pocket of the intermediate (IM) state of TREK-1. |
| PC-24563 |
ROMK inhibitor Compound A
ROMK inhibitor
|
ROMK inhibitor Compound A is a potent, highly selective inhibitor renal outer medullary potassium (ROMK, Kir1.1) channel with IC50 of 24 nM, displays good selectivity across other ion channel superfamilies. |
| PC-24561 |
MK-8153
ROMK inhibitor
|
MK-8153 (MK8153) is a potent, selective inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) with IC50 of 5 nM, 3,400-fold over hERG. |
| PC-24166 |
Opakalim
Kv7 activator
|
Opakalim is a potent, selective small molecule activator of Kv7 potassium channel. |
| PC-23868 |
Ebio2
KCNQ2 activator
|
Ebio2 is a potent, subtype-selective activator of potassium channel KCNQ2 (Kv7.2) with EC50 of 1.9 nM for activation on the outward current amplitude of the KCNQ2 channel at +50 mV. |
| PC-23682 |
Vernakalant hydrochloride
K+ channel blocker
|
Vernakalant (RSD1235) is an atrial-selective antifibrillatory agent and mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker, inhibits wild-type and mutant Kv1.5 channels. |
| PC-23611 |
VU0134992 hydrochloride
Kir4.1 inhibitor
|
VU0134992 hydrochloride(VU 0134992) is a potent, selective blocker of the inward rectifier potassium channel Kir4.1 (KCNJ10) with IC50 of 0.97 uM in whole-cell patch clamp electrophysiology assays. |
| PC-23603 |
SKA-346
KCa3.1 activator
|
SKA-346 is a selective activator of calcium-activated KCa3.1 channel with EC50 of 1.9 uM, does not activate KCa1.1, KCa2.2 and KCa2.3 up to 30 uM. |
| PC-23274 |
VU0531245
KNa1.1 (Slack) inhibitor
|
VU0531245 (VU245) is a potent, selective SLACK channel (KNa1.1) inhibitor, inhibits WT SLACK channels with IC50 of 2.1 uM. |
