| Cat. No. |
Product Name |
Information |
| PC-21482 |
NPBA
TASK-3 activator
|
NPBA is a potent, selective pharmacological activator for K2P channel TASK-3 with EC50 of 6.7 uM (TASK-3 whole-cell currents), shows good selectivity between TASK channels. |
| PC-21229 |
VU0935685
KNa1.1 (Slack) inhibitor
|
VU0935685 is a potent, selective inhibitor of SLACK potassium channels with IC50 of 0.32 uM in in whole-cell, voltage-clamp electrophysiology (EP) assays, demonstrates selectivity versus hERG. |
| PC-20943 |
ML252
KCNQ2 inhibitor
|
ML252 is a potent and selective, brain penetrant inhibitor of KCNQ2 (Kv 7.2) with IC50 of 69 nM, EC50 of 170 nM. |
| PC-20753 |
BK channel modulator BC5
BK channel modulator
|
BK channel modulator BC5 is an allosteric modulator of BK type Ca2+-activated K+ channels, interacts with the CTD-VSD interface and specifically modulates the Ca2+ dependent activation mechanism. |
| PC-20702 |
ML308
KCNK9 inhibitor
|
ML308 (ML 308) is a potent, selective inhibitor of two-pore domain potassium channel KCNK9 (TASK-3, K2P9.1) with IC50 of 130 nM in thallium influx fluorescent assays and 413 nM in automated electrophysiology assays, respectively. |
| PC-20698 |
PK-THPP
TASK-3 inhibitor
|
TASK-3 inhibitor 23 is a potent, selective inhibitor of TWIK-related acid-sensitive K+ (K2P9.1, TASK-3) ion channel with IC50 of 30 nM, 10-fold selectivity over TASK-1. |
| PC-20697 |
A1899
TASK-1 inhibitor
|
A1899 (A-1899) is a potent and highly selective blocker of the K(2P) channel TASK-1, selectively blocks human TASK-1 channels expressed in Xenopus oocytes with IC50 of 35.1 nM. |
| PC-49797 |
ACOU001
KV7.4 activator
|
ACOU001 (ACOU 001) is a potent small-molecule agonist of Kv7.4 (KCNQ4) channel with potential effect against ge-related hearing loss (ARHL) and other hearing impairments related to compromised KV7.4 function. |
| PC-60806 |
RY796 R-form
|
A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively. |
| PC-60805 |
RY796 racemate
|
A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively. |
| PC-46826 |
Mitiglinide calcium hydrate
|
An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells. |
| PC-45221 |
Mitiglinide calcium
|
An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells. |
