| Cat. No. |
Product Name |
Information |
| PC-42069 |
PAP-1
Kv1.3 inhibitor
|
PAP-1 is a potent, selective small molecule lymphocyte K+ channel Kv1.3 blocker with EC50 of 2 nM. |
| PC-45844 |
Senicapoc
KCa3.1 inhibitor
|
Senicapoc (ICA-17043) is a potent, selective Gardos channel (KCa3.1) blocker that blocks Ca(2+)-induced rubidium flux from human RBCs (IC50=11 nM) and inhibits RBC dehydration (IC50=10-50 nM). |
| PC-42381 |
GAL-021
BKCa inhibitor
|
GAL-021 (ENA-001) is a respiratory stimulant that acts as a potent calcium-activated potassium (BKCa, KCa1.1) channel blocker blocker. |
| PC-46030 |
Dronedarone
Potassium channel inhibitor, USP11 inhibitor
|
Dronedarone (SR33589) is a multichannel blocker agent that has antiarrhythmic activity, reduces the late sustained K(+) current, I(K) (or Isus) with EC50 of 0.85 uM in postmyocardial infarcted (PMI) rats. |
| PC-45962 |
Dronedarone hydrochloride
|
Dronedarone hydrochloride (SR33589) is a multichannel blocker agent that has antiarrhythmic activity, reduces the late sustained K(+) current, I(K) (or Isus) with EC50 of 0.85 uM in postmyocardial infarcted (PMI) rats. |
| PC-45472 |
Azimilide dihydrochloride
hERG inhibitor
|
Azimilide dihydrochloride is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel; blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively. |
| PC-45471 |
Azimilide
hERG inhibitor
|
Azimilide (NE-10064) is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel, blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively. |
| PC-47402 |
Quinidine
|
A class I antiarrhythmic agent (Ia) that works by blocking the fast inward sodium current (INa). |
| PC-27792 |
P-retigabine
Kv7 activator
|
P-retigabine (P-RTG) is a Retigabine analog with improved brain distribution and neuronal Kv7 channel activator with EC50 of 2.04 uM (KCNQ2, Kv7.2), displays moderate anticonvulsant efficacy. |
| PC-27791 |
SF0034
Kv7.2/7.3 activator
|
SF0034 is a potent, sepcific KCNQ2/3 (Kv7.2/7.3) channel activator, shiftes the V1/2 of KCNQ2/3 currents with EC50 of 1.3 uM. |
| PC-27790 |
Zinc Pyrithione
KCNQ potassium channel activator
|
Zinc pyrithione (Zn-Pyrithione, ZnPy) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump, potentiates potassium currents induced by KCNQ homomultimers, show agonistic activity for KCNQ channels, potently activates both heterologous and native M channels by inducing channel opening at the resting potential, also is a copper ionophore. |
| PC-27787 |
Kv7 blocker compound 106
Kv7 blocker
|
Kv7 blocker compound 106 (C106) is a potent, subtype-selective Kv7 blocker with IC50 of 33.1 nM for Kv7.2/3 channels, without affecting cardiac Kv7.1 channels. |
