| Cat. No. |
Product Name |
Information |
| PC-24598 |
TKIM
TREK-1 inhibitor
|
TKIM is a small molecule TREK-1 channel inhibitor with an IC50 of 2.96 μM, binds to the pocket of the intermediate (IM) state of TREK-1. |
| PC-24597 |
ONO-TR-772
TERK inhibitor
|
ONO-TR-772 (VU6018042) is a potent, selective and CNS penetrant TREK (TWIK related K+ channel) inhibitor with IC50 of 15 nM (TREK-1, human manual patch clamp (MPC)), equipotent with TREK-2. |
| PC-24563 |
ROMK inhibitor Compound A
ROMK inhibitor
|
ROMK inhibitor Compound A is a potent, highly selective inhibitor renal outer medullary potassium (ROMK, Kir1.1) channel with IC50 of 24 nM, displays good selectivity across other ion channel superfamilies. |
| PC-24561 |
MK-8153
ROMK inhibitor
|
MK-8153 (MK8153) is a potent, selective inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) with IC50 of 5 nM, 3,400-fold over hERG. |
| PC-24166 |
Opakalim
Kv7 activator
|
Opakalim is a potent, selective small molecule activator of Kv7 potassium channel. |
| PC-23868 |
Ebio2
KCNQ2 activator
|
Ebio2 is a potent, subtype-selective activator of potassium channel KCNQ2 (Kv7.2) with EC50 of 1.9 nM for activation on the outward current amplitude of the KCNQ2 channel at +50 mV. |
| PC-23682 |
Vernakalant hydrochloride
K+ channel blocker
|
Vernakalant (RSD1235) is an atrial-selective antifibrillatory agent and mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker, inhibits wild-type and mutant Kv1.5 channels. |
| PC-23611 |
VU0134992 hydrochloride
Kir4.1 inhibitor
|
VU0134992 hydrochloride(VU 0134992) is a potent, selective blocker of the inward rectifier potassium channel Kir4.1 (KCNJ10) with IC50 of 0.97 uM in whole-cell patch clamp electrophysiology assays. |
| PC-23603 |
SKA-346
KCa3.1 activator
|
SKA-346 is a selective activator of calcium-activated KCa3.1 channel with EC50 of 1.9 uM, does not activate KCa1.1, KCa2.2 and KCa2.3 up to 30 uM. |
| PC-23274 |
VU0531245
KNa1.1 (Slack) inhibitor
|
VU0531245 (VU245) is a potent, selective SLACK channel (KNa1.1) inhibitor, inhibits WT SLACK channels with IC50 of 2.1 uM. |
| PC-23273 |
KNa1.1 blocker Z05
KNa1.1 (Slack) inhibitor
|
KNa1.1 blocker Z05 is a selective potential KNa1.1 (Slack, Slo2.2, or KCa4.1) inhibitor with IC50 of 3.4 uM and 0.2 uM for WT KNa1.1 and mutant Y796H respectively. |
| PC-23263 |
C28
KCNQ1 activator
|
C28 is a specific small molecule activator of cardiac potassium ion channel IKs (KCNQ1+KCNE1), causes change of V1/2 of G-V relations with EC50 of 7.6 uM, interacts with the KCNQ1 voltage-sensing domain (VSD), and shifts voltage dependence of VSD activation to more negative voltages. |
