| Cat. No. |
Product Name |
Information |
| PC-45472 |
Azimilide dihydrochloride
hERG inhibitor
|
Azimilide dihydrochloride is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel; blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively. |
| PC-45471 |
Azimilide
hERG inhibitor
|
Azimilide (NE-10064) is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel, blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively. |
| PC-47402 |
Quinidine
|
A class I antiarrhythmic agent (Ia) that works by blocking the fast inward sodium current (INa). |
| PC-28479 |
Bupivacaine
NMDAR antagonist, Sodium channel blocker
|
Bupivacaine is a long-acting aminoamide local anesthetic agent and N-methyl-D-aspartate (NMDA) receptor blocker, blocks sodium, L-calcium, and potassium channels, potently blocks SCN5A channels (Nav1.5 sodium channel alpha subunit) with IC50 of 69.5 uM, inhibits human neuronal Kv3 channels in SH-SY5Y human neuroblastoma cells. |
| PC-28408 |
Amiodarone
Potassium channel inhibitor
|
Amiodarone is a class III antiarrhythmic agent that inhibits voltage- and ligand-gated potassium channel currents (IK, IK,Na, IK,ACh), also causes a down-regulation of Kv1.5 messenger ribonucleic acid (mRNA) in rat hearts, inhibits outward ionic current (IhERG) tails with IC50 of 45 nM, also induces cell proliferation and myofibroblast differentiation. |
| PC-28406 |
Dalazatide TFA
Kv1.3 inhibitor
|
Dalazatide TFA (ShK-186) is a potent, selective inhibitor of voltage-gated potassium channel Kv1.3 with IC50 of 69 pM, exhibits enhanced selectivity for Kv1.3 over Kv1.1, alleviates obesity and insulin resistance. |
| PC-28405 |
Dalazatide
Kv1.3 inhibitor
|
Dalazatide (ShK-186) is a potent, selective inhibitor of voltage-gated potassium channel Kv1.3 with IC50 of 69 pM, exhibits enhanced selectivity for Kv1.3 over Kv1.1, alleviates obesity and insulin resistance. |
| PC-28404 |
Z299576254
Kv1.3 inhibitor
|
Z299576254 is a safe and potent voltage-gated potassium channel Kv1.3 inhibitor, suppresses macrophage inflammatory responses by modulating the PI3K/AKT signaling pathway. |
| PC-28401 |
NS8593
SK channel inhibitor, TRPM7 inhibitor
|
NS8593 is a potent and selective small conductance Ca2+-activated K+ channels (SK channels) inhibitor, reversibly inhibits recombinant SK3-mediated currents with potencies around 100 nM. |
| PC-28392 |
Minoxidil
KATP channel opener
|
Minoxidil (U10858) is a potent oral antihypertensive agent and a peripheral vasodilator, is an ATP-sensitive potassium (KATP) channel opener, is also a potent inhibitor of soybean lipoxygenaseare with IC50 of 20 uM. |
| PC-28334 |
Glimepiride
Anti-diabetic, K(ATP) channel SUR1 inhibitor
|
Glimepiride (HOE-490) is a sulfonylurea anti-diabetic compound that blocks the ATP-sensitive potassium channel, binds to inhibits to the sulfonylurea receptor 1 (SUR1/Kir6.2) component of ATP sensitive potassium (K ATP) channels located on pancreatic beta cells, shows binding IC50 of 3.0 nM for SUR1, 5.4 nM for SUR2A and 7.3 nM for SUR2B. |
| PC-28189 |
UK-78282 hydrochloride
Kv1.3 inhibitor
|
UK-78282 hydrochloride is a selective inhibitor of Kv1.3 voltage-gated potassium channel with IC50 of 200 nM, shows preferentially blocking and binding to the C-type inactivated state of the channel, displays marked selectivity for Kv1.3 over other closely related K+ channels. |
