| Cat. No. |
Product Name |
Information |
| PC-23125 |
SZV-2649
Potassium channel activator
|
SZV-2649 is a small molecule multiple ion channel inhibitor, inhibits hERG and GIRK currents in HEK cells with IC50 of 342 and 529 nM respectively, shows antiarrhythmic effects. |
| PC-22989 |
BA6b9
SK4 channel blocker
|
BA6b9 is a small molecule, allosteric SK4 channel blocker, reversibly inhibits the SK4 currents with IC50 of 8.6 uM, targets Ca2+-calmodulin (CaM)-PIP2-binding domain. |
| PC-22937 |
Tertiapin-Q
GIRK channel inhibitor
|
Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and renal outer medullary potassium channel (ROMK1, Kir1.1), blocks recombinant and native large conductance K+ channels. |
| PC-22929 |
TMEM175 inhibitor AP-6
TMEM175 inhibitor
|
TMEM175 inhibitor AP-6 is a selective TMEM175 inhibitor, increases lysosomal degradative activity. |
| PC-22741 |
CAT335
TREK-1 activator
|
CAT335 is a small molecule covalent K2P2.1 (TREK-1) channel activator, selectively and irreversibly activates K2P2.1(TREK-1) S131C variant (TREK-1CG∗), but not wild-type K2P2.1(TREK-1) |
| PC-22728 |
Nigericin
Potassium ionophore, NLRP3 agonist
|
Nigericin (NSC 292567) is an ionophore antibiotic derived from S. hygroscopicus that acts as a potassium ionophore promoting K+/H+ exchange across mitochondrial membranes. |
| PC-22574 |
ASP0819
KCa3.1 opener
|
ASP0819 is a potent, selective and orally active intermediate conductance channel KCa3.1 (IK1) opener with EC50 and Emax values of 102.4 nM and 99.0%, and 392.9 nM and 102.4% in human and rat KCa3.1-expressing cells, respectively. |
| PC-22563 |
VU0948578
KNa1.1 (Slack) inhibitor
|
VU0948578 is a potent, selective inhibitor of WT, A934T, and G288S SLACK channel (KCNT1, KNa1.1) with IC50 of 0.70, 0.59, 0.71 µM respectively. |
| PC-22457 |
BMS-986308
ROMK inhibitor
|
BMS-986308 is a potent, selective inhibitor of renal outer medullary potassium (ROMK, Kir1.1, KCNJ1) channel with IC50 of 24 nM. |
| PC-22388 |
CPK20
KNa1.1 (Slack) inhibitor
|
CPK20 is a potent, selective inhibitor / blocker of potassium (K+) channel KCNT1 (KNa1.1, Slo2.2, SLACK) with IC50 of 6.4 uM in fluorescence-based assay FluxOR. |
| PC-22096 |
BMS191095
KATP opener
|
BMS191095 (BMS-191095) is a selective ATP-sensitive potassium channel (KATP) opener, exhibits antiischemic (cardioprotective) potency with EC25 of 1.4 uM. |
| PC-21845 |
Tamapin TFA
SK2 channel inhibitor
|
Tamapin TFA salt is a venom peptide from the Indian red scorpion (Mesobuthus tamulus), potent and selective inhibitor of small conductance calcium-activated potassium channel 2 (SK2, KCNN2) with IC50 of 24 pM. |
