| Cat. No. |
Product Name |
Information |
| PC-27786 |
Kv7 activator compound 60
Kv7 activator
|
Kv7 activator compound 60 is a potent and photochemically stable neuronal Kv7 channel activator with EC50 of 0.1 uM for Kv7.2/Kv7.3 channels. |
| PC-27765 |
Mutant KCNJ5 agonist C105
KCNJ5 agonist
|
Mutant KCNJ5 agonist C105 is a selective, first-in-class mutant KCNJ5 (GIRK4) agonist, increases mutant KCNJ5-induced cell death in adrenal cells, without affecting cells expressing wild-type KCNJ5. |
| PC-27689 |
AUT5
Kv3.1/3.2 modulator
|
AUT5 is a highly selective positive allosteric modulator of Kv3.1 and Kv3.2 channels, induces positive cooperativity and preferential stabilization of the open state with EC50 of 3.2 uM (Kv3.2). |
| PC-27590 |
JG-C3-98
TASK-1/TASK-3 activator
|
JG-C3-98 is a selective and effective activator of K2P channels TASK-1 and TASK-3 with EC50 of 13 uM and 34 uM for hTASK-1 and hTASK-3, respectively. |
| PC-27392 |
UA49
KAT1 inhibitor
|
UA49 is a small molecule inhibitor of plant inward-rectifying potassium channel KAT1, KAT2, promotes a decrease in the cytosolic K+ content in guard cells, conferring significant drought tolerance in Arabidopsis. |
| PC-27285 |
Tenidap
Kir2.3 agonist, 5-LOX/COX inhibitor
|
Tenidap (CP-66248) is an orally active dual inhibitor of 5-LOX and cyclooxygenase (COX) with anti-inflammatory and immunomodulatory properties.
Tenidap (CP-66248) reduces A 23187-stimulated LTB4 (IC50=18 uM) and PGE2 (IC50=32 nM) synthesis. |
| PC-26570 |
CHET3
TASK-3 agonist
|
CHET3 is a highly selective allosteric activator for TASK-3-containing K2P channels, including TASK-3 homomers and TASK-3/TASK-1 heteromers, displayspotent analgesic effects. |
| PC-26491 |
KCa3.1-IN-1
KCa3.1 inhibitor
|
KCa3.1-IN-1 is a selective small-molecule extracellular inhibitor of KCa3.1 channel (KCNN4) with IC50 of 43.1 uM in duplicate whole-cell patch clamp recordings. |
| PC-26490 |
GLA-1-1
BK channel agonist
|
GLA-1-1 is a small-molecule agonist of large-conductance Ca²⁺-activated K⁺ (BK) channels with EC50 of 3.4 uM, induces autophagy flux by promoting autophagosome-lysosome fusion. |
| PC-26438 |
IQM-22110
KV4.3/KChIP modulator
|
IQM-22110 is a selective small molecule modulator of KV4.3/KChIP channels with IC50 of 28 nM and binding affinity (Kd) of 230 nM to KChIP3, selective for KV4.3/KChIP3 over KV4.3/KChIP2 and KV4.3 channels. |
| PC-26200 |
JX3212
Kir4.1 Inhibitor
|
JX3212 is a potent, specific and brain penetrant inhibitor of inwardly rectifying potassium channel 4.1 (Kir4.1, KCNJ10) with IC50 of 0.28 uM (−120 mV) and 0.19 uM (+50 mV). |
| PC-26171 |
Apamin TFA
SK channel inhibitor
|
Apamin (Apamine) TFA is a peptide neurotoxin found in apitoxin and selective small conductance Ca(2+)-activated K(+) (SK(Ca)) channel blocker, exhibits anti-inflammatory and anti-fibrotic activity. |
