| Cat. No. |
Product Name |
Information |
| PC-42381 |
GAL-021
BKCa inhibitor
|
GAL-021 is a respiratory stimulant that acts as a potent calcium-activated potassium (BKCa, KCa1.1) channel blocker blocker. |
| PC-46030 |
Dronedarone
Potassium channel inhibitor
|
Dronedarone (SR33589) is a multichannel blocker agent that has antiarrhythmic activity, reduces the late sustained K(+) current, I(K) (or Isus) with EC50 of 0.85 uM in postmyocardial infarcted (PMI) rats. |
| PC-45962 |
Dronedarone hydrochloride
|
Dronedarone hydrochloride (SR33589) is a multichannel blocker agent that has antiarrhythmic activity, reduces the late sustained K(+) current, I(K) (or Isus) with EC50 of 0.85 uM in postmyocardial infarcted (PMI) rats. |
| PC-45472 |
Azimilide dihydrochloride
hERG inhibitor
|
Azimilide dihydrochloride is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel; blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively. |
| PC-45471 |
Azimilide
hERG inhibitor
|
Azimilide (NE-10064) is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel, blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively. |
| PC-47402 |
Quinidine
|
A class I antiarrhythmic agent (Ia) that works by blocking the fast inward sodium current (INa). |
| PC-25953 |
SK2 channel activator Compound 4
SK2 channel activator
|
SK2 channel activator Compound 4 is a potent, selective activator of small conductance calcium-activated potassium channel 2 (SK2), dose-dependently increases SK2 current in the presence of 2 µM intracellular Ca2+. |
| PC-25952 |
SK2 channel inhibitor Compound 1
SK2 channel inhibitor
|
SK2 channel inhibitor Compound 1 is a potent, selective inhibitor of small conductance calcium-activated potassium channel 2 (SK2) with IC50 of 69 nM, with 10-fold reduced potency for SK4 (IC50=660 nM), has high selectivity over other ion channels tested including hERG, Nav1.5, KCNQ1, and Cav1.2. |
| PC-25626 |
ONO-7927846
TERK inhibitor
|
ONO-7927846 (VU6024391) is a selective and CNS penetrant TWIK-related K+ channels (TREK) inhibitor with IC50 of 110 nM and 290 nM for human TREK-1 and TREK-2 in thallium flux assays respectively. |
| PC-25625 |
ONO-9517601
TERK inhibitor
|
ONO-9517601 (VU6022856) is a selective and CNS penetrant TWIK-related K+ channels (TREK) inhibitor with IC50 of 67 nM and 230 nM for human TREK-1 and TREK-2 in thallium flux assays respectively. |
| PC-25574 |
VU6080824
Kir2.1 inhibitor
|
VU6080824 is a potent, selective inhibitor of the inward-rectifier potassium channel Kir2.1 with IC50 of 5.9 uM in Kir2.1 thallium flux assays, selective relative to Kir1.1 and Kir4.1 up to 10 uM. |
| PC-25544 |
VU6032735
SLO3 inhibitor
|
VU6032735 is a highly potent, subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitor with IC50 of 165 nM (hSLO3), 172-fold selective over hERG. |
