| Cat. No. |
Product Name |
Information |
| PC-22096 |
BMS191095
KATP opener
|
BMS191095 (BMS-191095) is a selective ATP-sensitive potassium channel (KATP) opener, exhibits antiischemic (cardioprotective) potency with EC25 of 1.4 uM. |
| PC-21845 |
Tamapin TFA
SK2 channel inhibitor
|
Tamapin TFA salt is a venom peptide from the Indian red scorpion (Mesobuthus tamulus), potent and selective inhibitor of small conductance calcium-activated potassium channel 2 (SK2, KCNN2) with IC50 of 24 pM. |
| PC-21738 |
PNU37883A
Kir6 inhibitor
|
PNU37883A (PNU37883 hydrochloride) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker with IC50 of 6 uM and 15 uM for Kir6.1/SUR2B and Kir6.2/SUR2B, respectively. |
| PC-21737 |
Pinacidil
Potassium channel activator
|
Pinacidil (P-1134) is a potent activator of potassium channel, hyperpolarises vascular smooth muscle by opening K+-channels, significantly improves the reperfusion function and cardiac compliance and has direct cardioprotective efficacy. |
| PC-21736 |
Glibenclamide
SUR1 inhibitor
|
Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor, directly binds and blocks the SUR1 subunits of KATP. |
| PC-21735 |
VU0071063
Kir6.2/SUR1 activator
|
VU0071063 is a potent and specific Kir6.2/SUR1 opener with EC50 of 7.44 uM, inhibits insulin secretion by inducing hyperpolarization of β-cell membrane potential. |
| PC-21733 |
VU0542270
Kir6.1/SUR2B inhibitor
|
VU0542270 is the first selective inhibitor of vascular Kir6.1/SUR2B KATP channel with IC50 of 129 nM, >300-fold selective over other members of the Kir channel family. |
| PC-21704 |
Guangxitoxin 1E
Kv2 channel inhibitor
|
Guangxitoxin 1E is a potent, specific inhibitor of Kv2.1 (KCNB1) and Kv2.2 with IC50 of 1-3 nM, has no significant effect on KV1.2, KV1.3, KV1.5, KV3.2 and BK potassium channels, also inactive against calcium and sodium channels CaV1.2, CaV2.2, NaV1.5, NaV1.7, NaV1.8. |
| PC-21613 |
KCNQ2 activator Ebio1
KCNQ2 activator
|
KCNQ2 activator Ebio1 is a potent and subtype-selective activator for the voltage-gated potassium channel KCNQ2 (Kv7.2) with EC50 of 247.3 nM, directly opens the KCNQ2 channel. |
| PC-21564 |
AUT00201
Kv3 modulator
|
AUT00201 is a potent, selective Kv3 potassium channel modulator with potential for the treatment of rare epilepsy syndromes. |
| PC-21483 |
NPBA-4
TWIK2 inhibitor
|
NPBA-4 is a potent selective TWIK2 channel inhibitor with IC50 of 8.41 uM. shows little to no effects on TWIK1 channel. |
| PC-21482 |
NPBA
TASK-3 activator
|
NPBA is a potent, selective pharmacological activator for K2P channel TASK-3 with EC50 of 6.7 uM (TASK-3 whole-cell currents), shows good selectivity between TASK channels. |
