| Cat. No. |
Product Name |
Information |
| PC-28188 |
UK-78282
Kv1.3 inhibitor
|
UK-78282 is a selective inhibitor of Kv1.3 voltage-gated potassium channel with IC50 of 200 nM, shows preferentially blocking and binding to the C-type inactivated state of the channel, displays marked selectivity for Kv1.3 over other closely related K+ channels. |
| PC-27792 |
P-retigabine
Kv7 activator
|
P-retigabine (P-RTG) is a Retigabine analog with improved brain distribution and neuronal Kv7 channel activator with EC50 of 2.04 uM (KCNQ2, Kv7.2), displays moderate anticonvulsant efficacy. |
| PC-27791 |
SF0034
Kv7.2/7.3 activator
|
SF0034 is a potent, sepcific KCNQ2/3 (Kv7.2/7.3) channel activator, shiftes the V1/2 of KCNQ2/3 currents with EC50 of 1.3 uM. |
| PC-27790 |
Zinc Pyrithione
KCNQ potassium channel activator
|
Zinc pyrithione (Zn-Pyrithione, ZnPy) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump, potentiates potassium currents induced by KCNQ homomultimers, show agonistic activity for KCNQ channels, potently activates both heterologous and native M channels by inducing channel opening at the resting potential, also is a copper ionophore. |
| PC-27787 |
Kv7 blocker compound 106
Kv7 blocker
|
Kv7 blocker compound 106 (C106) is a potent, subtype-selective Kv7 blocker with IC50 of 33.1 nM for Kv7.2/3 channels, without affecting cardiac Kv7.1 channels. |
| PC-27786 |
Kv7 activator compound 60
Kv7 activator
|
Kv7 activator compound 60 is a potent and photochemically stable neuronal Kv7 channel activator with EC50 of 0.1 uM for Kv7.2/Kv7.3 channels. |
| PC-27765 |
Mutant KCNJ5 agonist C105
KCNJ5 agonist
|
Mutant KCNJ5 agonist C105 is a selective, first-in-class mutant KCNJ5 (GIRK4) agonist, increases mutant KCNJ5-induced cell death in adrenal cells, without affecting cells expressing wild-type KCNJ5. |
| PC-27689 |
AUT5
Kv3.1/3.2 modulator
|
AUT5 is a highly selective positive allosteric modulator of Kv3.1 and Kv3.2 channels, induces positive cooperativity and preferential stabilization of the open state with EC50 of 3.2 uM (Kv3.2). |
| PC-27392 |
UA49
KAT1 inhibitor
|
UA49 is a small molecule inhibitor of plant inward-rectifying potassium channel KAT1, KAT2, promotes a decrease in the cytosolic K+ content in guard cells, conferring significant drought tolerance in Arabidopsis. |
| PC-27285 |
Tenidap
Kir2.3 agonist, 5-LOX/COX inhibitor
|
Tenidap (CP-66248) is an orally active dual inhibitor of 5-LOX and cyclooxygenase (COX) with anti-inflammatory and immunomodulatory properties.
Tenidap (CP-66248) reduces A 23187-stimulated LTB4 (IC50=18 uM) and PGE2 (IC50=32 nM) synthesis. |
| PC-26570 |
CHET3
TASK-3 agonist
|
CHET3 is a highly selective allosteric activator for TASK-3-containing K2P channels, including TASK-3 homomers and TASK-3/TASK-1 heteromers, displayspotent analgesic effects. |
| PC-26491 |
KCa3.1-IN-1
KCa3.1 inhibitor
|
KCa3.1-IN-1 is a selective small-molecule extracellular inhibitor of KCa3.1 channel (KCNN4) with IC50 of 43.1 uM in duplicate whole-cell patch clamp recordings. |
